Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZG5WL)

• Drug Name: Emapalumab Drug Info
• Synonyms: emapalumab; Emapalumab [INN]; Emapalumab [USAN:INN]; UNII-3S252O2Z4X; 3S252O2Z4X

Indication

Disease Entry	ICD 11	Status	REF
Primary haemophagocytic lymphohistiocytosis	4A01.23	Approved	[1]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2/3	[2]

• Cross-matching ID: TTD Drug ID: DMZG5WL

Molecule-Related Drug Atlas

Drug(s) Targeting Interferon-gamma (IFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fumaric acid	DMP83UZ	Multiple sclerosis	8A40	Phase 3	[5]
VIR-201	DMAMIU4	Human immunodeficiency virus infection	1C62	Phase 1/2	[6]
CIGB-128	DMB2MKU	Basal cell carcinoma	2C32	Phase 1	[7]
AMG 811	DMEIMBP	Discoid lupus erythematosus	EB51.0	Phase 1	[8]
CRx-191	DMB9QSJ	Psoriatic disorder	EA90	Discontinued in Phase 2	[9]
TAK-603	DMN1YHP	Inflammatory bowel disease	DD72	Discontinued in Phase 2	[10]
Fontolizumab	DMEH6LV	Inflammatory bowel disease	DD72	Discontinued in Phase 2	[11]
TG-1042	DMS4BUK	B-cell lymphoma	2A86	Discontinued in Phase 2	[12]
VPM-4-001	DMZHAVG	Prostate cancer	2C82.0	Preclinical	[13]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interferon-gamma (IFNG)	TT93WF5	IFNG_HUMAN	Modulator	[3]
HUMAN interferon gamma (IFNG)	TTR10KI	IFNG_HUMAN	Inhibitor	[4]

References

• [1] FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (BLA) 761107.
• [2] ClinicalTrials.gov (NCT04324021) Efficacy and Safety of Emapalumab and Anakinra in Reducing Hyperinflammation and Respiratory Distress in Patients With COVID-19 Infection.. U.S. National Institutes of Health.
• [3] 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
• [4] Interferon-beta and interferon-gamma synergistically inhibit the replication of severe acute respiratory syndrome-associated coronavirus (SARS-CoV). Virology. 2004 Nov 10;329(1):11-7. doi: 10.1016/j.virol.2004.08.011.
• [5] Emerging oral drugs for multiple sclerosis. Expert Opin Emerg Drugs. 2008 Sep;13(3):465-77.
• [6] EP patent application no. 17782511, Nucleoside phosphonate conjugates as anti hiv agents.
• [7] Pharmacokinetic and pharmacodynamic characterization of a new formulation containing synergistic proportions of interferons alpha-2b and gamma (HeberPAG) in patients with mycosis fungoides: an open-label trial.BMC Pharmacol Toxicol.2012 Dec 28;13:20.
• [8] Pharmacokinetic and pharmacodynamic relationship of AMG 811, an anti-IFN-gamma IgG1 monoclonal antibody, in patients with systemic lupus erythematosus. Pharm Res. 2015 Feb;32(2):640-53.
• [9] CombinatoRx Drug Candidate CRx-191 Demonstrates Positive Phase 2 Results In Psoriasis. CombinatoRx. 2008.
• [10] T helper 1 inhibitor TAK-603 inhibits IFN-gamma and IL-12 production with no effect on IL-18: an observation in sarcoidosis patients. Sarcoidosis Vasc Diffuse Lung Dis. 2004 Oct;21(3):204-11.
• [11] Emerging drugs to treat Crohn's disease. Expert Opin Emerg Drugs. 2007 Mar;12(1):49-59.
• [12] Drug evaluation: TG-1042, an adenovirus-mediated IFNgamma gene delivery for the intratumoral therapy of primary cutaneous lymphomas. Curr Opin Investig Drugs. 2007 Jun;8(6):493-8.
• [13] BioPartnering North America--Programs from Pharma in Europe and the Middle East. IDrugs. 2010 Mar;13(3):162-5.