Details of the Drug Reposition

General Information of This Drug (ID: DM4PXF6)

• Drug Name: Desoximetasone (DM4PXF6)
• Synonyms: Desoximetasona; Desoximetasonum; Topicort; HOE-304; R-2113; Topicort (TN); Topicort Emollient (TN); A-41-304; Desoximetasone (USP/INN); (11beta,16alpha)-9-Fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione; (8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one; 9-Fluoro-11beta,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione; 9alpha-fluoro-16alpha-methyl-Delta(1)-corticosterone
• Therapeutic Class: Antiinflammatory Agents
• Drug Type: Small molecular drug

Information on Drug Reposition of This Drug

4 Approved Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Primary cutaneous T-cell lymphoma	DIS35WVW	N.A.	Approved	[1]
Granuloma annulare	DISMOUMI	N.A.	Approved	[1]
Exanthem	DISAFOQN	N.A.	Approved	[1]
Inflammation	DISJUQ5T	1A00-CA43.1	Approved	[2]

1 Discontinued in Phase 2 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Contact dermatitis	DISQ3AU0	EK0Z	Discontinued in Phase 2	[3]

2 Discontinued in Phase 1 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Atopic dermatitis	DISTCP41	EA80	Discontinued in Phase 1	[4]
Seborrhoeic dermatitis	DISNWVJU	EA81	Discontinued in Phase 1	[5]

References

• [1] Desoximetasone FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7067).
• [3] ClinicalTrials.gov (NCT01166126) Temsirolimus/AZD 6244 for Treatment-naive With BRAF Mutant Unresectable Stage IV
• [4] ZD6474 Alone and in Combination With Retinoic Acid in Pediatric Neuroblastoma
• [5] Behavioral Therapy Development for Methamphetamine Abuse