Details of Disease

General Information of Disease (ID: DISQ3AU0)

Disease Name Contact dermatitis
Synonyms contact eczema; contact dermatitis; dermatitis venenata; dermatitis, venenata; contact dermatitis/eczema
Disease Class EK00-EK0Z: Contact dermatitis
Definition An inflammatory skin condition caused by direct contact between the skin and either an irritating substance or an allergen.
Disease Hierarchy
DISY5SZC: Dermatitis
DISQ3AU0: Contact dermatitis
ICD Code
ICD-11
ICD-11: EK0Z
ICD-9
ICD-9: 692
Expand ICD-11
'EK0Z
Expand ICD-10
'L25; 'L25.0; 'L25.2; 'L25.3; 'L25.4; 'L25.5; 'L25.8; 'L25.9
Expand ICD-9
692
Disease Identifiers
MONDO ID
MONDO_0005480
MESH ID
D003877
UMLS CUI
C0011616
MedGen ID
8329
HPO ID
HP:0032282
SNOMED CT ID
40275004

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 2 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Bentoquatam DMPE8ZG Approved Small molecular drug [1]
Flumethasone Pivalate DMU0YP6 Approved Small molecular drug [2]
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This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
MRX-6 DMLVQKF Phase 2 NA [3]
PDC-APB DM9K588 Phase 1 NA [4]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 48 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
AHR TT037IE Limited Biomarker [5]
CASP8 TT6SZNG Limited Biomarker [5]
CCN2 TTIL516 Limited Biomarker [5]
CCR1 TTC24WT Limited Biomarker [5]
CD44 TTWFBT7 Limited Biomarker [5]
CD86 TT53XHB Limited Biomarker [5]
CTSS TTUMQVO Limited Biomarker [5]
CXCR3 TT1UCIJ Limited Biomarker [5]
CYP1B1 TTI84H7 Limited Biomarker [5]
DUSP1 TTG8HIM Limited Biomarker [5]
FABP4 TTHWMFZ Limited Biomarker [5]
FTH1 TT975ZT Limited Biomarker [5]
G6PD TTKN8W0 Limited Biomarker [5]
GLB1 TTNGJPH Limited Biomarker [5]
GSR TTEP6RV Limited Biomarker [5]
GSS TTVEWR4 Limited Biomarker [5]
GSTP1 TT40K12 Limited Biomarker [5]
HDAC4 TTTQGH8 Limited Biomarker [5]
HMOX1 TTI6V2A Limited Biomarker [5]
HSP90AA1 TT78R5H Limited Biomarker [5]
HSPB1 TT9AZWY Limited Biomarker [5]
IGFBP2 TTU4QSN Limited Biomarker [5]
IGFBP6 TTLAYV8 Limited Biomarker [5]
IL18 TTRICUF Limited Biomarker [5]
MLANA TT362RB Limited Biomarker [5]
MMP10 TTXLEG7 Limited Biomarker [5]
MMP8 TTGA1IV Limited Biomarker [5]
NQO1 TT8XK6L Limited Biomarker [5]
NQO2 TTJLP0R Limited Biomarker [5]
NRG1 TTEH395 Limited Biomarker [5]
OSM TTIVXSE Limited Biomarker [5]
S100A8 TT4AF6N Limited Biomarker [5]
SERPINB3 TT6QLPX Limited Biomarker [5]
SLC7A11 TTBZMIO Limited Biomarker [5]
SOD1 TTP9K3Q Limited Biomarker [5]
STOML2 TTOI329 Limited Biomarker [5]
TLR8 TT8CWFK Limited Biomarker [5]
TPSAB1 TTM1TDX Limited Biomarker [5]
TXN TTZJ5U9 Limited Biomarker [5]
TXNRD1 TTR7UJ3 Limited Biomarker [5]
UGT1A1 TT34ZAF Limited Biomarker [5]
CD58 TT5KSBY Strong Genetic Variation [6]
CD70 TTNCIE0 Strong Biomarker [7]
CRHR1 TT7EFHR Strong Biomarker [8]
HPD TT8DSFC Strong Genetic Variation [9]
IL25 TTVMO5W Strong Altered Expression [10]
SAA1 TTY0DN9 Strong Biomarker [11]
TLR4 TTISGCA Strong Biomarker [12]
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⏷ Show the Full List of 48 DTT(s)
This Disease Is Related to 1 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC26A3 DTN1FMD Limited Genetic Variation [13]
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This Disease Is Related to 6 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
AKR1B10 DEP6GT1 Limited Biomarker [5]
AKR1C2 DEOY5ZM Limited Biomarker [5]
CYP1A1 DE6OQ3W Limited Biomarker [5]
GCLC DESYL1F Limited Biomarker [5]
UGT1A6 DESD26P Limited Biomarker [5]
HSD17B10 DEGSPC9 Strong Biomarker [6]
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⏷ Show the Full List of 6 DME(s)
This Disease Is Related to 19 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
CCL27 OTUZYC61 Limited Biomarker [5]
CXCL14 OTM189TA Limited Biomarker [5]
DDIT3 OTI8YKKE Limited Biomarker [5]
DEFB1 OT5SV0E4 Limited Biomarker [5]
ING1 OTEZBRKW Limited Biomarker [5]
KIF2C OTJ8G3NP Limited Biomarker [5]
KRT10 OTSVRD3Q Limited Biomarker [5]
KRT2 OTG2EZEN Limited Biomarker [5]
KRT4 OT24PHPM Limited Biomarker [5]
PI3 OT47MTC3 Limited Biomarker [5]
PIR OT8ALXHU Limited Biomarker [5]
PRDX6 OTS8KC8A Limited Biomarker [5]
PSMD12 OTWICA51 Limited Biomarker [5]
SERPINB4 OT88LHZ8 Limited Biomarker [5]
TNFSF9 OTV9L89D Limited Biomarker [5]
CLDN1 OT27KV99 moderate Genetic Variation [14]
CCN6 OTRFHQ2Z Strong Genetic Variation [9]
FLG OTE9QDV6 Strong Genetic Variation [15]
SOD3 OTIOZQAB Strong Therapeutic [16]
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⏷ Show the Full List of 19 DOT(s)

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7075).
3 ClinicalTrials.gov (NCT02031445) Double-Blind, Trial to Evaluate the Safety and Efficacy of MRX-6 Cream 2%. U.S. National Institutes of Health.
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Genes specifically modulated in sensitized skins allow the detection of sensitizers in a reconstructed human skin modelDevelopment of the SENS-IS assay. Toxicol In Vitro. 2015 Jun;29(4):787-802.
6 A novel murine model for the assessment of human CD2-related reagents in vivo.J Immunol. 1996 Sep 1;157(5):1863-9.
7 CD70 and Th17 are involved in human contact sensitivity.J Drugs Dermatol. 2011 Oct;10(10):1192-4.
8 Corticotropin-releasing factor receptor type 1 is involved in the stress-induced exacerbation of chronic contact dermatitis in rats.Exp Dermatol. 2003 Feb;12(1):47-52. doi: 10.1034/j.1600-0625.2003.120106.x.
9 The specificity of a nickel sulphate reaction in vitro: a family study and a study of chromium-allergic subjects.Scand J Immunol. 1981;13(3):231-5. doi: 10.1111/j.1365-3083.1981.tb00130.x.
10 IL-17E (IL-25) Enhances Innate Immune Responses during Skin Inflammation.J Invest Dermatol. 2019 Aug;139(8):1732-1742.e17. doi: 10.1016/j.jid.2019.01.021. Epub 2019 Feb 6.
11 Serum amyloid A-luciferase transgenic mice: response to sepsis, acute arthritis, and contact hypersensitivity and the effects of proteasome inhibition.J Immunol. 2005 Jun 15;174(12):8125-34. doi: 10.4049/jimmunol.174.12.8125.
12 Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity.J Exp Med. 2008 Sep 1;205(9):2151-62. doi: 10.1084/jem.20070509. Epub 2008 Aug 25.
13 Allergic contact dermatitis to nickel is associated with a Taq I HLA-DQA allelic restriction fragment.Immunogenetics. 1988;28(5):310-3. doi: 10.1007/BF00364228.
14 The role of glutathione S-transferase and claudin-1 gene polymorphisms in contact sensitization: a cross-sectional study.Br J Dermatol. 2013 Apr;168(4):762-70. doi: 10.1111/bjd.12126. Epub 2013 Jan 31.
15 Contact Allergy in Children with Atopic Dermatitis: A Retrospective Study.Endocr Metab Immune Disord Drug Targets. 2019;19(7):1083-1087. doi: 10.2174/1871530319666190211123342.
16 EC-SOD suppresses contact hypersensitivity in mouse skin by impairing Langerhans cell migration.J Invest Dermatol. 2007 Aug;127(8):1930-7. doi: 10.1038/sj.jid.5700802. Epub 2007 Mar 29.