Details of the Drug-Related molecule(s) Interaction Atlas

Norastemizole Drug Info

Tecastemizole; Soltara; UNII-W5DCO14M05; 75970-99-9; CHEMBL61301; W5DCO14M05; T 1348; 1-((4-Flurophenyl)methyl)-N-4-piperidinyl-1H-benzimidazol-2-amine; 1-(-Fluorobenzyl)-N-(piperidin-4-yl)-1H-benzimidazol-2-amine; 1H-Benzimidazol-2-amine, 1-((4-fluorophenyl)methyl)-N-4-piperidinyl-; Tecastemizole[USAN]; 75970-64-8; Tecastemizole [USAN:INN]; 1-(4-fluorobenzyl)-n-(piperidin-4-yl)-1h-benzimidazol-2-amine; AC1Q4NSA; AC1L3WZJ; Tecastemizole (USAN/INN); SCHEMBL18200; ZINC2303; DTXSID30226877

Cross-matching ID

PubChem CID

123618

CAS Number

CAS 75970-99-9

TTD Drug ID

DMXF0NS

General Information of Drug (ID: DMXF0NS)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Histamine H1 receptor (H1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[2]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[3]
Azelastine	DMXTMBJ	Allergic conjunctivitis	9A60.02	Approved	[4]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[5]
Cinnarizine	DM7U5QJ	Meniere disease	AB31.0	Approved	[6]
Diphenhydramine	DMKQTBA	Hyperemesis gravidarum		Approved	[4]
Doxepin	DMPI98T	Anxiety		Approved	[7]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[4]
Epinastine	DMX0K3Q	Allergic conjunctivitis	9A60.02	Approved	[8]
Desloratadine	DM56YN7	Allergic rhinitis	CA08.0	Approved	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	Effect of tecastemizole on pulmonary and cutaneous allergic inflammatory responses. Clin Exp Allergy. 2007 Jun;37(6):909-17.
2	Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6.
3	Clinical research of Ibudilast on treating the steroid resistant allergic rhinitis. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Jan;23(2):63-6.
4	Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization. J Pharmacol Sci. 2008 May;107(1):66-79.
5	Update on prescription and over-the-counter histamine inverse agonists in rhinitis therapy. Curr Allergy Asthma Rep. 2009 Mar;9(2):140-8.
6	Central effects of cinnarizine: restricted use in aircrew. Aviat Space Environ Med. 2002 Jun;73(6):570-4.
7	Novel therapeutic usage of low-dose doxepin hydrochloride. Expert Opin Investig Drugs. 2007 Aug;16(8):1295-305.
8	Influence of epinastine hydrochloride, an H1-receptor antagonist, on the function of mite allergen-pulsed murine bone marrow-derived dendritic cell... Mediators Inflamm. 2009;2009:738038.
9	Examining the tolerability of the non-sedating antihistamine desloratadine: a prescription-event monitoring study in England. Drug Saf. 2009;32(2):169-79.