Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT6HPVC)

• DTT Name: Guanylate cyclase (GC)
• Synonyms: Guanylyl Cyclase
• Gene Name: NO-GeName
• DTT Type: Successful target; [1]
• Related Disease:
  Acquired methaemoglobinaemia [ICD-11: 3A93]
  Anal fissure/fistula [ICD-11: DB50]
  Angina pectoris [ICD-11: BA40]
  Hydrocephalus [ICD-11: 8D64]
  Respiratory failure [ICD-11: CB41]
• BioChemical Class: Phosphorus-oxygen lyase
• UniProt ID: NOUNIPROTAC
• TTD ID: T71398

Molecular Interaction Atlas (MIA) of This DTT

5 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythrityl Tetranitrate	DMFGQ2S	Angina pectoris	BA40	Approved	[1], [2]
Isosorbide dinitrate	DMBI4JG	Anal fissure	DB50.0	Approved	[1], [3]
Isosorbide mononitrate	DMYLMU0	Hydrocephalus	8D64	Approved	[1], [4]
Methylene blue	DMJAPE7	Acquired methemoglobinemia	3A93	Approved	[5]
Nitric Oxide	DM1RBYG	Respiratory failure	CB41	Approved	[1]

2 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IW-1701	DM457XO	Sickle-cell disorder	3A51	Phase 2	[6]
Pirsidomine	DMHI6GE	Angina pectoris	BA40	Phase 2	[7]

References

• [1] Nitric oxide and nitric oxide synthase isoforms in the normal, hypertrophic, and failing heart. Mol Cell Biochem. 2010 Jan;333(1-2):191-201.
• [2] Nitric oxide modulation of the growth hormone-releasing activity of Hexarelin in young and old dogs. Metabolism. 1999 Feb;48(2):176-82.
• [3] No recovery of cold complex regional pain syndrome after transdermal isosorbide dinitrate: a small controlled trial. J Pain Symptom Manage. 2009 Sep;38(3):401-8.
• [4] Cervical priming in the first trimester: morphological and biochemical effects of misoprostol and isosorbide mononitrate. Acta Obstet Gynecol Scand. 2009;88(1):43-51.
• [5] Curcumin ameliorates high glucose-induced acute vascular endothelial dysfunction in rat thoracic aorta. Clin Exp Pharmacol Physiol. 2009 Dec;36(12):1177-82.
• [6] Clinical pipeline report, company report or official report of Cyclerion Therapeutics.
• [7] Activation of soluble guanylyl cyclase by the nitrovasodilator 3-morpholinosydnonimine involves formation of S-nitrosoglutathione. Mol Pharmacol. 1998 Jul;54(1):207-12.