Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT6HPVC)

DTT Name	Guanylate cyclase (GC) DTT Info
Gene Name	GC

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

5 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythrityl Tetranitrate	DMFGQ2S	Angina pectoris	BA40	Approved	[1]
Isosorbide Dinitrate	DMBI4JG	Anal fissure	DB50.0	Approved	[1]
Isosorbide Mononitrate	DMYLMU0	Angina pectoris	BA40	Approved	[1]
Methylene blue	DMJAPE7	Acquired methemoglobinemia	3A93	Approved	[2]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[1]
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2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IW-1701	DM457XO	Sickle-cell disorder	3A51	Phase 2	[3]
Pirsidomine	DMHI6GE	Angina pectoris	BA40	Phase 2	[4]
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Molecule Interaction Atlas

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References

1	Nitric oxide and nitric oxide synthase isoforms in the normal, hypertrophic, and failing heart. Mol Cell Biochem. 2010 Jan;333(1-2):191-201.
2	Curcumin ameliorates high glucose-induced acute vascular endothelial dysfunction in rat thoracic aorta. Clin Exp Pharmacol Physiol. 2009 Dec;36(12):1177-82.
3	Clinical pipeline report, company report or official report of Cyclerion Therapeutics.
4	Activation of soluble guanylyl cyclase by the nitrovasodilator 3-morpholinosydnonimine involves formation of S-nitrosoglutathione. Mol Pharmacol. 1998 Jul;54(1):207-12.