Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTGRHIB)

DTT Name UDP-glucose 4-epimerase (GALE)
Synonyms
UDP-galactose4-epimerase; UDP-galactose4'-epimerase; UDP-galactose 4-epimerase; UDP-N-acetylglucosamine 4-epimerase; UDP-N-acetylgalactosamine 4-epimerase; UDP-GlcNAc 4-epimerase; UDP-GalNAc 4-epimerase; Galactowaldenase
Gene Name GALE
DTT Type
Literature-reported target
 [1]
BioChemical Class
Racemases and epimerase
UniProt ID
GALE_HUMAN
TTD ID
T96014
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 5.1.3.2
Sequence
MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV
EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMK
AHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNA
VLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRD
YIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARR
EGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA
Function
The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids. Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine.
KEGG Pathway
Galactose metabolism (hsa00052 )
Amino sugar and nucleotide sugar metabolism (hsa00520 )
Metabolic pathways (hsa01100 )
Reactome Pathway
Galactose catabolism (R-HSA-70370 )
Defective GALE causes EDG (R-HSA-5609977 )
BioCyc Pathway
MetaCyc:HS04117-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
10 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotinamide-Adenine-Dinucleotide DM9LRKB N. A. N. A. Investigative [2]
Phenyl-Uridine-5'-Diphosphate DM7J0YG Discovery agent N.A. Investigative [2]
PSAMMAPLIN A DM6T0IQ Discovery agent N.A. Investigative [3]
Tetramethylammonium Ion DMLEPYN Discovery agent N.A. Investigative [2]
UDP-glucose DMLT4JA Discovery agent N.A. Investigative [2]
Uridine diphosphate galactose DMPA0BJ Discovery agent N.A. Investigative [1]
Uridine-5'-Diphosphate DMDQKJB Discovery agent N.A. Investigative [2]
Uridine-5'-Diphosphate-Mannose DMAYCQU Discovery agent N.A. Investigative [2]
Uridine-Diphosphate-N-Acetylgalactosamine DMXHO6J N. A. N. A. Investigative [2]
Uridine-Diphosphate-N-Acetylglucosamine DMEQSTP Discovery agent N.A. Investigative [4]
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⏷ Show the Full List of 10 Investigative Drug(s)

References

1 Crystal structure of beta1,4-galactosyltransferase complex with UDP-Gal reveals an oligosaccharide acceptor binding site. J Mol Biol. 2002 Apr 26;318(2):491-502.
2 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3 Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5744-7.
4 DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.