General Information of Drug Therapeutic Target (DTT) (ID: TTJIH8Q)

DTT Name CCR5 messenger RNA (CCR5 mRNA)
Synonyms
HIV-1 fusion coreceptor (mRNA); HIV-1 fusion co-receptor (mRNA); Chemokine receptor CCR5 (mRNA); CMKBR5 (mRNA); CHEMR13 (mRNA); CD195 antigen (mRNA); CD195 (mRNA); CCR-5 (mRNA); CC-CKR-5 (mRNA); C-C chemokine receptor type 5 (mRNA); C-C CKR-5 (mRNA)
Gene Name CCR5
DTT Type
Successful target
[1]
BioChemical Class
mRNA target
UniProt ID
CCR5_HUMAN
TTD ID
T72171
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
Function
May play a role in the control of granulocytic lineage proliferation or differentiation. Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level.
KEGG Pathway
Cytokine-cytokine receptor interaction (hsa04060 )
Chemokine signaling pathway (hsa04062 )
Endocytosis (hsa04144 )
Toxoplasmosis (hsa05145 )
Viral carcinogenesis (hsa05203 )
Reactome Pathway
Chemokine receptors bind chemokines (R-HSA-380108 )
G alpha (i) signalling events (R-HSA-418594 )
Binding and entry of HIV virion (R-HSA-173107 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Maraviroc DMTL94F Human immunodeficiency virus infection 1C62 Approved [1]
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1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
DdRNAi therapy rHIV7-shl-TAR-CCR5RZ, stem cells DM0I5LM Human immunodeficiency virus infection 1C62 Phase 1/2 [2]
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1 Discontinued Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
SCH-C DM8J9SF Human immunodeficiency virus infection 1C62 Discontinued in Phase 1 [3]
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1 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
viral macrophage inflammatory protein-II DMAXOPS Discovery agent N.A. Investigative [4]
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References

1 Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human. Biochem Pharmacol. 2005 Dec 19;71(1-2):163-72.
2 Progress on RNAi-based molecular medicines. Int J Nanomedicine. 2012; 7: 3971-3980.
3 Discovery and characterization of vicriviroc (SCH 417690), a CCR5 antagonist with potent activity against human immunodeficiency virus type 1. Antimicrob Agents Chemother. 2005 Dec;49(12):4911-9.
4 A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus. Science. 1997 Sep 12;277(5332):1656-9.