Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTJIH8Q)

• DTT Name: CCR5 messenger RNA (CCR5 mRNA) DTT Info
• Gene Name: CCR5

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Maraviroc	DMTL94F	Human immunodeficiency virus infection	1C62	Approved	[1]

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DdRNAi therapy rHIV7-shl-TAR-CCR5RZ, stem cells	DM0I5LM	Human immunodeficiency virus infection	1C62	Phase 1/2	[2]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SCH-C	DM8J9SF	Human immunodeficiency virus infection	1C62	Discontinued in Phase 1	[3]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
viral macrophage inflammatory protein-II	DMAXOPS	Discovery agent	N.A.	Investigative	[4]

References

• [1] Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human. Biochem Pharmacol. 2005 Dec 19;71(1-2):163-72.
• [2] Progress on RNAi-based molecular medicines. Int J Nanomedicine. 2012; 7: 3971-3980.
• [3] Discovery and characterization of vicriviroc (SCH 417690), a CCR5 antagonist with potent activity against human immunodeficiency virus type 1. Antimicrob Agents Chemother. 2005 Dec;49(12):4911-9.
• [4] A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus. Science. 1997 Sep 12;277(5332):1656-9.