Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTN5MZ3)

DTT Name	Ammonium transporter Rh type C (RHCG)
Synonyms	Tumor-related protein DRC2; Rhesus blood group family type C glycoprotein; Rh type C glycoprotein; Rh glycoprotein kidney; Rh family type C glycoprotein; RHGK; PDRC2; CDRC2; C15orf6
Gene Name	RHCG
DTT Type	Literature-reported target	[1]
UniProt ID	RHCG_HUMAN
TTD ID	T17291
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MAWNTNLRWRLPLTCLLLQVIMVILFGVFVRYDFEADAHWWSERTHKNLSDMENEFYYRY PSFQDVHVMVFVGFGFLMTFLQRYGFSAVGFNFLLAAFGIQWALLMQGWFHFLQDRYIVV GVENLINADFCVASVCVAFGAVLGKVSPIQLLIMTFFQVTLFAVNEFILLNLLKVKDAGG SMTIHTFGAYFGLTVTRILYRRNLEQSKERQNSVYQSDLFAMIGTLFLWMYWPSFNSAIS YHGDSQHRAAINTYCSLAACVLTSVAISSALHKKGKLDMVHIQNATLAGGVAVGTAAEMM LMPYGALIIGFVCGIISTLGFVYLTPFLESRLHIQDTCGINNLHGIPGIIGGIVGAVTAA SASLEVYGKEGLVHSFDFQGFNGDWTARTQGKFQIYGLLVTLAMALMGGIIVGLILRLPF WGQPSDENCFEDAVYWEMPEGNSTVYIPEDPTFKPSGPSVPSVPMVSPLPMASSVPLVP
Function	Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.
Reactome Pathway	Rhesus glycoproteins mediate ammonium transport (R-HSA-444411 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
[14C]methylamine	DMRBZ3X	Discovery agent	N.A.	Investigative	[1]
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The Drug Transporter (DTP) Role of This DTT

DTT DTP Name

Ammonium transporter Rh type C (SLC42A3) DTP Info

Gene Name

SLC42A3

1 Approved Drug(s) Transported by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ammonia	DMOEVK6	Coronary artery disease	BA80	Approved	[2]
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References

1	Characterization of ammonia transport by the kidney Rh glycoproteins RhBG and RhCG. Am J Physiol Renal Physiol. 2006 Feb;290(2):F297-305.
2	Functional analysis of human RhCG: comparison with E. coli ammonium transporter reveals similarities in the pore and differences in the vestibule. Am J Physiol Cell Physiol. 2009 Sep;297(3):C537-47.