Details of the Drug

General Information of Drug (ID: DMOEVK6)

Drug Name
Ammonia
Synonyms Ammonia N13
Indication
Disease Entry ICD 11 Status REF
Coronary artery disease BA80 Approved [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 17.031
Logarithm of the Partition Coefficient (xlogp) -0.7
Rotatable Bond Count (rotbonds) 0
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 1
ADMET Property
Half-life
The concentration or amount of drug in body reduced by one-half in 3 seconds [2]
Metabolism
The drug is metabolized via the hepatic [3]
Chemical Identifiers
Formula
H3N
IUPAC Name
azane
Canonical SMILES
N
InChI
InChI=1S/H3N/h1H3
InChIKey
QGZKDVFQNNGYKY-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
222
ChEBI ID
CHEBI:16134
CAS Number
7664-41-7
DrugBank ID
DB11118
TTD ID
D0FT7Y
VARIDT ID
DR00194
INTEDE ID
DR0100

Molecular Interaction Atlas of This Drug


Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Ammonium transporter Rh type C (SLC42A3) DTF3LTV RHCG_HUMAN Substrate [4]
Ammonium transporter Rh type B (SLC42A2) DTU6IF7 RHBG_HUMAN Substrate [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Glutamine synthetase (GLUL)
Main DME 		DE5UC73 GLNA_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Amine oxidase 3 (AOC3) OT30YKV0 AOC3_HUMAN Biotransformations [6]
Ammonium transporter Rh type C (RHCG) OT1MTYUH RHCG_HUMAN Regulation of Drug Effects [7]
Aquaporin-4 (AQP4) OTA9MYD5 AQP4_HUMAN Gene/Protein Processing [8]
Arylamine N-acetyltransferase 1 (NAT1) OTCCNQ3H ARY1_HUMAN Biotransformations [9]
Arylamine N-acetyltransferase 2 (NAT2) OTBPDQOY ARY2_HUMAN Drug Response [10]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Regulation of Drug Effects [9]
Glial fibrillary acidic protein (GFAP) OTQ01ZAS GFAP_HUMAN Gene/Protein Processing [8]
Glycine amidinotransferase, mitochondrial (GATM) OTIJ4Z11 GATM_HUMAN Gene/Protein Processing [11]
Guanidinoacetate N-methyltransferase (GAMT) OTVC87ES GAMT_HUMAN Gene/Protein Processing [11]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Gene/Protein Processing [8]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9.
2 Ammonia - National Library of Medicine HSDB Database - Toxnet - NIH
3 Agarwal SK, Hu B, Chien D, Wong SL, Salem AH: Evaluation of Rifampin's Transporter Inhibitory and CYP3A Inductive Effects on the Pharmacokinetics of Venetoclax, a Bcl-2 Inhibitor: Results of a Single- and Multiple-dose Study. J Clin Pharmacol. 2016 Mar 7. doi: 10.1002/jcph.730.
4 Functional analysis of human RhCG: comparison with E. coli ammonium transporter reveals similarities in the pore and differences in the vestibule. Am J Physiol Cell Physiol. 2009 Sep;297(3):C537-47.
5 Ammonia metabolism capacity of HepG2 cells with high expression of human glutamine synthetase. Hepatobiliary Pancreat Dis Int. 2008 Dec;7(6):621-7.
6 Anti-inflammatory effects of inhibiting the amine oxidase activity of semicarbazide-sensitive amine oxidase. J Pharmacol Exp Ther. 2005 Nov;315(2):553-62. doi: 10.1124/jpet.105.089649. Epub 2005 Aug 4.
7 Expression of the ammonia transporter, rh C glycoprotein, in normal and neoplastic human kidney. J Am Soc Nephrol. 2006 Oct;17(10):2670-9. doi: 10.1681/ASN.2006020160. Epub 2006 Aug 23.
8 Ammonia and proinflammatory cytokines modify expression of genes coding for astrocytic proteins implicated in brain edema in acute liver failure. Metab Brain Dis. 2010 Mar;25(1):17-21.
9 GST, NAT, SULT1A1, CYP1B1 genetic polymorphisms, interactions with environmental exposures and bladder cancer risk in a high-risk population. Int J Cancer. 2004 Jul 1;110(4):598-604. doi: 10.1002/ijc.20157.
10 Urinary mutagenicity, CYP1A2 and NAT2 activity in textile industry workers. J Occup Health. 2004 Nov;46(6):440-7. doi: 10.1539/joh.46.440.
11 Ammonia toxicity to the brain: effects on creatine metabolism and transport and protective roles of creatine. Mol Genet Metab. 2010;100 Suppl 1:S53-8. doi: 10.1016/j.ymgme.2010.02.011. Epub 2010 Feb 14.