Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTOVFH2)

• DTT Name: Bacterial 30S ribosomal RNA (Bact 30S rRNA)
• Gene Name: NO-GeName
• DTT Type: Successful target; [1]
• Related Disease:
  Acne vulgaris [ICD-11: ED80]
  Bacterial infection [ICD-11: 1A00-1C4Z]
  Gingival/edentulous alveolar ridge disorder [ICD-11: DA0D]
  Infectious gastroenteritis/colitis [ICD-11: 1A40]
  Periodontal disease [ICD-11: DA0C]
  Pneumonia [ICD-11: CA40]
  Skin sensation disturbance [ICD-11: ME65]
• UniProt ID: NOUNIPROTAC
• TTD ID: T62094

Molecular Interaction Atlas (MIA) of This DTT

7 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxycycline	DM7ICNU	Advanced gum disease	DA0D	Approved	[2]
Gentamicin	DMKINJO	Bacterial infection	1A00-1C4Z	Approved	[2]
Nitrofurazone	DMSM2KE	Skin burns	ME65.0	Approved	[1]
Omadacycline	DMR2J95	Acute bacterial skin infection	1C41	Approved	[3]
Sarecycline	DMLZNIQ	Acne vulgaris	ED80	Approved	[4]
Tobramycin	DMUI0CH	Bacterial infection	1A00-1C4Z	Approved	[5]
TP-434	DM5A31S	Intra-abdominal infection	1A40	Approved	[6]

4 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ME1100	DM39PSZ	Bacterial pneumonia	CA40.0	Phase 1	[7]
TP 6076	DMD0NA1	Multidrug resistant infection	MG51	Phase 1	[8]
TP-271	DM3PJSE	Pneumonia	CA40	Phase 1	[9]
TP-6076	DM5RIT8	Enterobacteriaceae infection	MG50.C	Phase 1	[8]

2 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Wetimicin	DMSZJ5H	Infectious disease	1A00-CA43.1	Discontinued in Phase 1	[10]
DACTIMICIN	DMZ8OMT	Bacterial infection	1A00-1C4Z	Terminated	[11]

References

• [1] The antibiotic Furvina targets the P-site of 30S ribosomal subunits and inhibits translation initiation displaying start codon bias. Nucleic Acids Res. 2012 Nov 1;40(20):10366-74.
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [3] Omadacycline Enters the Ring: A New Antimicrobial Contender.Pharmacotherapy. 2018 Dec;38(12):1194-1204.
• [4] Microbiological Profile of Sarecycline, a Novel Targeted Spectrum Tetracycline for the Treatment of Acne Vulgaris.Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01297-18.
• [5] Mechanism of action of aminoglycoside antibiotics.Binding studies of tobramycin and its 6'-N-acetyl derivative to the bacterial ribosome and its subunits.Eur J Biochem.1979 Dec;102(1):73-81.
• [6] The antibiotic arms race: current and emerging therapy for Klebsiella pneumoniae carbapenemase (KPC) - producing bacteria.Expert Opin Pharmacother. 2018 Oct 22:1-13.
• [7] ClinicalTrials.gov (NCT01961830) Intrapulmonary Pharmacokinetics of ME1100 in Healthy Volunteers. U.S. National Institutes of Health.
• [8] Clinical pipeline report, company report or official report of Tetraphase Pharmaceuticals.
• [9] Clinical pipeline report, company report or official report of Tetraphase Pharmaceuticals.
• [10] Cross susceptibility of ototoxicity about aminoglycoside antibiotics. Lin Chuang Er Bi Yan Hou Ke Za Zhi. 1997 Jan;11(1):9-10.
• [11] Aminoglycosides: Activity and Resistance. Antimicrob Agents Chemother. 1999 April; 43(4): 727-737.