Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DEAZDL8)

• DME Name: UDP-glucuronosyltransferase 2B17 (UGT2B17) DME Info
• Gene Name: UGT2B17

Molecule-Related Drug & Molecule List

3 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Darolutamide	DMV7YFT	Prostate cancer	2C82.0	Approved	[1]
Denopamine	DM8C3GN	Cardiac disease	BA00-BE2Z	Approved	[2]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[3]

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MK-7246	DMLQOF1	Respiratory disease	CB40	Phase 1	[4]

3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BRN-1980310	DMOTU4P	N. A.	N. A.	Investigative	[5]
Hydroxybenzo(a)pyrene	DM9H5EN	N. A.	N. A.	Investigative	[5]
Hydroxybenzo[a]pyrene	DMFSKYE	N. A.	N. A.	Investigative	[5]

References

• [1] Drug-drug interaction potential of darolutamide: in vitro and clinical studies. Eur J Drug Metab Pharmacokinet. 2019 Dec;44(6):747-759.
• [2] Regioselective glucuronidation of denopamine: marked species differences and identification of human udp-glucuronosyltransferase isoform. Drug Metab Dispos. 2005 Mar;33(3):403-12.
• [3] Age-dependent hepatic UDP-glucuronosyltransferase gene expression and activity in children. Front Pharmacol. 2016 Nov 16;7:437.
• [4] UGT2B17 genetic polymorphisms dramatically affect the pharmacokinetics of MK-7246 in healthy subjects in a first-in-human study. Clin Pharmacol Ther. 2012 Jul;92(1):96-102.
• [5] Importance of UDP-glucuronosyltransferase 1A10 (UGT1A10) in the detoxification of polycyclic aromatic hydrocarbons: decreased glucuronidative activity of the UGT1A10139Lys isoform. Drug Metab Dispos. 2006 Jun;34(6):943-9.