Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DEDPI65)

DME Name	Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info
Gene Name	nfsA

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Discontinued Drug(s)

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

3 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Loperamide	DMOJZQ9	Diarrhea	ME05.1	Approved	[1]
Nitrazepam	DMEGIQ6	Epilepsy	8A60-8A68	Approved	[2]
Nitrofurazone	DMSM2KE	Skin burns	ME65.0	Approved	[2]
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1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
HSDB-674	DMJG4WR	N. A.	N. A.	Phase 1	[3]
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1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CB1954	DMVP4YK	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 2	[4]
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Molecule Interaction Atlas

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References

1	Reduction of the prodrug loperamide oxide to its active drug loperamide in the gut of rats, dogs, and humans. Drug Metab Dispos. 1995 Mar;23(3):354-62.
2	Biochemical characterization of NfsA, the Escherichia coli major nitroreductase exhibiting a high amino acid sequence homology to Frp, a Vibrio harveyi flavin oxidoreductase. J Bacteriol. 1996 Aug;178(15):4508-14.
3	Absorption of (-)-nicotine-l-N-oxide in man and its reduction in the gastrointestinal tract. J Pharm Pharmacol. 1970 Sep;22(9):722-3.
4	Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954. Biochem Pharmacol. 2010 Mar 1;79(5):678-87.