Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DELOY3P)

• DME Name: UDP-glucuronosyltransferase 1A4 (UGT1A4) DME Info
• Gene Name: UGT1A4

Molecule-Related Drug & Molecule List

6 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Anastrozole	DMNP60F	Breast cancer	2C60-2C65	Approved	[]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1]
Ketotifen	DM74XKS	Allergic conjunctivitis	9A60.02	Approved	[]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[2]
Lorlatinib	DMICDLV	Non-small-cell lung cancer	2C25.Y	Approved	[3]
Rilpivirine	DMJ0QOW	Human immunodeficiency virus infection	1C62	Approved	[4]

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bevirimat	DML2D8Q	Human immunodeficiency virus infection	1C62	Phase 2	[5]
LM-94	DMW3QGJ	N. A.	N. A.	Phase 1/2	[6]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
UDP-glucuronic acid	DMW16X2	Discovery agent	N.A.	Investigative	[6]

References

• [1] Identification of human UDP-glucuronosyltransferases catalyzing hepatic 1alpha,25-dihydroxyvitamin D3 conjugation. Biochem Pharmacol. 2008 Mar 1;75(5):1240-50.
• [2] Studies on induction of lamotrigine metabolism in transgenic UGT1 mice. Xenobiotica. 2009 Nov;39(11):826-35.
• [3] FDA label of Lorlatinib. The 2020 official website of the U.S. Food and Drug Administration.
• [4] Human biotransformation of the nonnucleoside reverse transcriptase inhibitor rilpivirine and a cross-species metabolism comparison. Antimicrob Agents Chemother. 2013 Oct;57(10):5067-79.
• [5] Bevirimat: a novel maturation inhibitor for the treatment of HIV-1 infection. Antivir Chem Chemother. 2008;19(3):107-13.
• [6] Identification of aspartic acid and histidine residues mediating the reaction mechanism and the substrate specificity of the human UDP-glucuronosyltransferases 1A. J Biol Chem. 2007 Dec 14;282(50):36514-24.