Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DEQX145)

• DME Name: Aromatase (CYP19A1) DME Info
• UniProt ID: CP19A_HUMAN
• Gene Name: CYP19A1

Molecule-Related Drug & Molecule List

7 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Letrozole	DMH07Y3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[1]
Levomethadyl acetate hydrochloride	DM429AE	Opioid dependence	6C43.2Z	Approved	[2]
Methadone	DMTW6IU	Dry cough	MD12	Approved	[3]
Nandrolone	DMFWKG1	Osteoporosis	FB83.0	Approved	[4]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[5]
Testosterone cypionate	DMC1TEV	Testosterone deficiency	5A81.1	Approved	[6]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[7]

References

• [1] Double-blind, randomised, multicentre endocrine trial comparing two letrozole doses, in postmenopausal breast cancer patients. Eur J Cancer. 1999 Feb;35(2):208-13.
• [2] N-demethylation of levo-alpha-acetylmethadol by human placental aromatase. Biochem Pharmacol. 2004 Mar 1;67(5):885-92.
• [3] Bidirectional transfer of methadone across human placenta. Biochem Pharmacol. 2005 Jan 1;69(1):187-97.
• [4] Aromatization of testosterone and 19-nortestosterone by a single enzyme from equine testicular microsomes. Differences from human placental aromatase. J Steroid Biochem. 1988 Jan;29(1):119-25.
• [5] Urinary and serum octopamine in patients with portal-systemic encephalopathy. Lancet. 1975 Nov 15;2(7942):943-6.
• [6] Loss of aromatase cytochrome P450 function as a risk factor for Parkinson's disease? Brain Res Rev. 2008 Mar;57(2):431-43.
• [7] Identifying susceptibility genes for prostate cancer--a family-based association study of polymorphisms in CYP17, CYP19, CYP11A1, and LH-beta. Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):2035-9.