Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEQX145)

DME Name Aromatase (CYP19A1)
Synonyms Cytochrome P-450AROM; Cytochrome P450 19A1; Estrogen synthase; ARO1; CYAR; CYP19; CYP19A1; CYPXIX
Gene Name CYP19A1
UniProt ID
CP19A_HUMAN
INTEDE ID
DME0002
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Gene ID
1588
EC Number EC: 1.14.14.14
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.14
Lineage Species: Homo sapiens
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Sequence
MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL
GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI
YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH
PDETKNMLEMIFTPRNSDRCLEH
Function
This enzyme catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. It catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Additionally, it converts dihydrotestosterone to delta1,10-dehydro 19- nordihydrotestosterone and also displays 2-hydroxylase activity toward estrone.
KEGG Pathway
Metabolic pathways (hsa01100 )
Ovarian steroidogenesis (hsa04913 )
Steroid hormone biosynthesis (hsa00140 )
Reactome Pathway
Endogenous sterols (R-HSA-211976 )
Estrogen biosynthesis (R-HSA-193144 )
Defective CYP19A1 causes Aromatase excess syndrome (AEXS) (R-HSA-5579030 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
7 Approved Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Letrozole DMH07Y3 Hormonally-responsive breast cancer 2C60-2C65 Approved [57]
Levomethadyl acetate hydrochloride DM429AE Opioid dependence 6C43.2Z Approved [58]
Methadone DMTW6IU Dry cough MD12 Approved [59]
Nandrolone DMFWKG1 Osteoporosis FB83.0 Approved [60]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [61]
Testosterone cypionate DMC1TEV Testosterone deficiency 5A81.1 Approved [62]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [63]
⏷ Show the Full List of 7 Approved Drug(s)

Molecular Expression Atlas (MEA) of This DME

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DME
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 5.28E-01 3.01E-02 1.98E-01
Alopecia ED70 Skin from scalp 7.59E-01 7.47E-03 3.33E-02
Alzheimer's disease 8A20 Entorhinal cortex 1.64E-01 -3.30E-02 -2.10E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 9.73E-01 -1.26E-01 -1.17E+00
Aortic stenosis BB70 Calcified aortic valve 5.80E-01 1.52E-01 4.07E-01
Apnea 7A40 Hyperplastic tonsil 2.93E-01 -2.25E-01 -1.06E+00
Arthropathy FA00-FA5Z Peripheral blood 1.09E-01 -4.42E-02 -4.05E-01
Asthma CA23 Nasal and bronchial airway 7.04E-02 3.25E-02 1.78E-01
Atopic dermatitis EA80 Skin 4.90E-04 1.17E-01 1.20E+00
Autism 6A02 Whole blood 4.32E-02 -5.56E-02 -2.96E-01
Autoimmune uveitis 9A96 Peripheral monocyte 9.33E-02 -9.88E-02 -1.74E+00
Autosomal dominant monocytopenia 4B04 Whole blood 6.88E-02 1.86E-01 2.35E+00
Bacterial infection of gingival 1C1H Gingival tissue 1.28E-01 7.80E-02 4.39E-01
Batten disease 5C56.1 Whole blood 3.66E-01 2.58E-02 3.11E-01
Behcet's disease 4A62 Peripheral blood 7.83E-01 -3.13E-02 -2.22E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 7.78E-01 -3.59E-02 -3.05E-01
Bladder cancer 2C94 Bladder tissue 1.60E-02 3.24E-01 1.05E+00
Breast cancer 2C60-2C6Z Breast tissue 5.83E-02 -2.39E-02 -1.09E-01
Cardioembolic stroke 8B11.20 Whole blood 4.38E-01 1.27E-02 5.87E-02
Cervical cancer 2C77 Cervical tissue 7.29E-01 4.31E-02 1.12E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 3.01E-01 4.89E-02 3.88E-01
Chronic hepatitis C 1E51.1 Whole blood 6.73E-01 -8.70E-03 -6.79E-02
Chronic obstructive pulmonary disease CA22 Lung tissue 3.49E-01 4.29E-02 4.65E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 3.88E-02 6.17E-02 5.26E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 5.34E-01 6.39E-02 6.84E-01
Colon cancer 2B90 Colon tissue 8.32E-01 1.59E-02 7.12E-02
Coronary artery disease BA80-BA8Z Peripheral blood 2.95E-01 -1.84E-01 -1.01E+00
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 4.04E-01 3.71E-02 4.48E-01
Endometriosis GA10 Endometrium tissue 1.26E-01 -9.54E-03 -7.76E-02
Familial hypercholesterolemia 5C80.00 Peripheral blood 5.09E-01 2.41E-02 1.99E-01
Familial hypercholesterolemia 5C80.00 Whole blood 5.73E-01 5.36E-02 2.76E-01
Gastric cancer 2B72 Gastric tissue 2.26E-01 8.78E-02 7.95E-01
Glioblastopma 2A00.00 Nervous tissue 4.03E-08 -8.93E-02 -4.28E-01
Glioma 2A00.0Y-2A00.0Z Brain stem tissue 3.81E-01 -9.68E-02 -1.26E+00
Glioma 2A00.0Y-2A00.0Z White matter tissue 9.20E-01 -2.32E-01 -7.47E-01
Head and neck cancer 2D42 Head and neck tissue 1.38E-15 1.42E-01 1.13E+00
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 1.75E-02 -1.95E-01 -9.85E-01
Huntington's disease 8A01.10 Whole blood 4.60E-01 -4.92E-02 -3.26E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 4.56E-01 -7.03E-02 -2.63E-01
Immunodeficiency 4A00-4A20 Peripheral blood 2.69E-02 7.98E-02 6.22E-01
Influenza 1E30 Whole blood 1.68E-01 1.85E-01 1.71E+00
Interstitial cystitis GC00.3 Bladder tissue 6.22E-01 4.83E-02 2.40E-01
Intracranial aneurysm 8B01.0 Intracranial artery 1.67E-02 -1.49E-01 -7.15E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 1.33E-01 1.17E-01 3.99E-01
Ischemic stroke 8B11 Peripheral blood 8.17E-01 -1.92E-02 -1.68E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 2.55E-05 1.22E-01 7.37E-01
Lateral sclerosis 8B60.4 Skin 7.95E-01 3.84E-02 3.89E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 5.27E-01 3.00E-02 2.29E-01
Liver cancer 2C12.0 Liver tissue 8.77E-01 -1.28E-02 -7.21E-02
Liver failure DB99.7-DB99.8 Liver tissue 6.45E-01 2.61E-02 2.30E-01
Lung cancer 2C25 Lung tissue 1.81E-07 8.48E-02 5.24E-01
Lupus erythematosus 4A40 Whole blood 5.63E-06 1.26E-01 5.46E-01
Major depressive disorder 6A70-6A7Z Hippocampus 2.12E-01 3.01E-02 2.47E-01
Major depressive disorder 6A70-6A7Z Whole blood 1.14E-01 5.68E-02 2.49E-01
Melanoma 2C30 Skin 2.07E-01 -1.37E-01 -4.16E-01
Multiple myeloma 2A83.1 Peripheral blood 8.01E-01 -6.10E-03 -8.61E-02
Multiple myeloma 2A83.1 Bone marrow 1.14E-03 -4.08E-01 -2.35E+00
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 3.16E-01 -5.50E-02 -1.79E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 1.55E-02 5.45E-02 4.84E-01
Myelofibrosis 2A20.2 Whole blood 9.16E-02 1.52E-01 1.02E+00
Myocardial infarction BA41-BA50 Peripheral blood 3.86E-03 1.40E-01 5.07E-01
Myopathy 8C70.6 Muscle tissue 9.98E-01 -8.95E-02 -5.90E-01
Neonatal sepsis KA60 Whole blood 2.18E-06 1.15E-01 6.20E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 1.76E-03 -3.58E-01 -1.59E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 3.09E-02 -9.78E-02 -8.60E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 1.09E-01 5.19E-02 4.81E-01
Olive pollen allergy CA08.00 Peripheral blood 5.98E-02 1.86E-01 9.21E-01
Oral cancer 2B6E Oral tissue 9.74E-01 -1.51E-02 -5.05E-02
Osteoarthritis FA00-FA0Z Synovial tissue 3.01E-01 -3.95E-01 -1.16E+00
Osteoporosis FB83.1 Bone marrow 5.09E-01 1.88E-02 1.39E-01
Ovarian cancer 2C73 Ovarian tissue 6.15E-02 -3.42E-01 -4.11E-01
Pancreatic cancer 2C10 Pancreas 6.96E-02 -6.62E-02 -1.90E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 8.69E-01 -1.95E-02 -1.02E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 4.47E-01 -6.54E-03 -4.55E-02
Pituitary cancer 2D12 Pituitary tissue 1.63E-01 1.58E-02 1.28E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 6.26E-01 -1.04E-02 -8.79E-02
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 1.91E-01 -1.20E-01 -3.42E-01
Polycythemia vera 2A20.4 Whole blood 6.57E-03 8.68E-02 6.25E-01
Pompe disease 5C51.3 Biceps muscle 7.43E-02 -9.92E-02 -1.18E+00
Preterm birth KA21.4Z Myometrium 3.82E-01 5.30E-02 3.95E-01
Prostate cancer 2C82 Prostate 4.12E-01 2.66E-02 9.79E-02
Psoriasis EA90 Skin 9.89E-01 5.04E-02 1.51E-01
Rectal cancer 2B92 Rectal colon tissue 7.28E-01 -1.25E-01 -6.48E-01
Renal cancer 2C90-2C91 Kidney 1.28E-03 -2.41E-01 -1.81E+00
Retinoblastoma 2D02.2 Uvea 9.72E-01 -1.20E-01 -6.41E-01
Rheumatoid arthritis FA20 Synovial tissue 1.49E-02 -6.86E-01 -1.28E+00
Rhinovirus infection CA42.1 Nasal epithelium tissue 8.01E-01 2.40E-02 1.76E-01
Schizophrenia 6A20 Prefrontal cortex 6.75E-01 -1.52E-03 -1.06E-02
Schizophrenia 6A20 Superior temporal cortex 2.98E-01 -3.41E-02 -2.10E-01
Scleroderma 4A42.Z Whole blood 4.46E-03 1.26E-01 1.31E+00
Seizure 8A60-8A6Z Whole blood 9.56E-01 3.53E-02 2.09E-01
Sensitive skin EK0Z Skin 4.96E-01 7.30E-02 1.09E+00
Sepsis with septic shock 1G41 Whole blood 3.55E-58 3.47E-01 1.52E+00
Shwachman-Diamond syndrome 3A70.0 Bone marrow 6.80E-01 6.63E-02 3.47E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 3.65E-01 -1.90E-02 -7.52E-02
Simpson golabi behmel syndrome LD2C Adipose tissue 8.81E-01 -2.00E-02 -4.01E-01
Sjogren's syndrome 4A43.2 Salivary gland tissue 9.78E-01 1.24E-02 6.69E-02
Skin cancer 2C30-2C3Z Skin 6.02E-02 -2.27E-04 -7.38E-04
Thrombocythemia 3B63 Whole blood 1.50E-01 1.84E-02 1.30E-01
Thrombocytopenia 3B64 Whole blood 8.90E-01 1.94E-02 1.57E-01
Thyroid cancer 2D10 Thyroid 3.98E-01 -2.83E-02 -1.67E-01
Tibial muscular dystrophy 8C75 Muscle tissue 1.92E-04 -1.80E-01 -1.31E+00
Tuberous sclerosis complex LD2D.2 Perituberal tissue 1.58E-01 1.20E-01 1.54E+00
Type 2 diabetes 5A11 Liver tissue 4.59E-01 4.41E-02 4.31E-01
Ureter cancer 2C92 Urothelium 7.43E-01 -1.35E-01 -3.79E-01
Uterine cancer 2C78 Endometrium tissue 3.49E-05 9.70E-02 4.03E-01
Vitiligo ED63.0 Skin 2.50E-02 -2.61E-01 -1.35E+00
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⏷ Show the Full List of DME Expression Under 107 Diseases

The Drug Therapeutic Target (DTT) Role of This DME

DME DTT Name Aromatase (CYP19A1) DTT Info
DME DTT Type Successful
6 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aminoglutethimide DMWFHMZ Cushing disease 5A70 Approved [1]
Anastrozole DMNP60F Breast cancer 2C60-2C65 Approved [2], [3]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [4]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [5]
Letrozole DMH07Y3 Hormonally-responsive breast cancer 2C60-2C65 Approved [4]
Testolactone DMVY4GN Breast cancer 2C60-2C65 Approved [3], [6]
⏷ Show the Full List of 6 Approved Drug(s)
6 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Atamestane + Toremifene DM3QLK2 Breast cancer 2C60-2C65 Phase 3 [7]
LIAROZOLE DM4OYXE Dermatological disease DA24.Y Phase 2/3 [8]
BGS-649 DMO4MNQ Endometriosis GA10 Phase 2 [9]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [10]
Dextromethorphan+quinidine DMFI5J4 Diabetic neuropathy 8C0Z Phase 2 [11]
Naringenin DMHAZLM N. A. N. A. Phase 1 [8]
⏷ Show the Full List of 6 Clinical Trial Drug(s)
7 Discontinued Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
FORMESTANE DMWIDJK Breast cancer 2C60-2C65 Withdrawn from market [12]
FINROZOLE DM06SC9 Prostate disease GA91 Discontinued in Phase 2 [13], [14]
NKS-01 DMV5FN1 Bladder cancer 2C94 Discontinued in Phase 2 [15], [14]
VOROZOLE DM32N5G N. A. N. A. Discontinued in Phase 2 [16]
YM-511 DM7WDAG Breast cancer 2C60-2C65 Discontinued in Phase 2 [17]
MINAMESTANE DM7IXH3 Bladder cancer 2C94 Terminated [18], [14]
Rogletimide DM6JO30 Breast cancer 2C60-2C65 Terminated [19]
⏷ Show the Full List of 7 Discontinued Drug(s)
220 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
(+/-)-7-methoxy-2-(4-methoxyphenyl)chroman-4-one DMYJGDK Discovery agent N.A. Investigative [20]
(+/-)-7-methoxy-2-phenylchroman-4-one DMC0OKA Discovery agent N.A. Investigative [21]
(2S)-5,7,2',4'-tetrahydroxyflavanone DMYVBHT Discovery agent N.A. Investigative [22]
(2S)-abyssinone II DM5V3M1 Discovery agent N.A. Investigative [22]
(2S)-euchrenone a7 DM6L0KZ Discovery agent N.A. Investigative [22]
1-(1-Benzyl-2-biphenyl-4-yl-ethyl)-1H-imidazole DMLBCE5 Discovery agent N.A. Investigative [23]
1-(2-(benzo[b]thiophen-4-yl)ethyl)-1H-imidazole DMB3HI4 Discovery agent N.A. Investigative [24]
1-(2-phenoxybenzyl)-1H-imidazole DMLY4ER Discovery agent N.A. Investigative [25]
1-(3-(4-fluorophenyl)propyl)-1H-imidazole DMWKXZ2 Discovery agent N.A. Investigative [8]
1-(3-Methoxy-naphthalen-2-yl)-1H-imidazole DM16U5F Discovery agent N.A. Investigative [26]
1-(4-Aminophenyl)-2-(1H-imidazol-1-yl)ethanone DMMYT4W Discovery agent N.A. Investigative [27]
1-(4-Cyanobenzyl)-5-methyl-1H-imidazole DMKC52N Discovery agent N.A. Investigative [28]
1-(4-nitro-2-phenoxybenzyl)-1H-imidazole DMSRBUE Discovery agent N.A. Investigative [25]
1-(4-Nitro-2-phenylsulfanylbenzyl)-1H-imidazole DMCP089 Discovery agent N.A. Investigative [25]
1-(7-Methoxy-2-phenyl-chroman-4-yl)-1H-imidazole DMLHDE3 Discovery agent N.A. Investigative [29]
1-(9-phenyl-9H-fluoren-9-yl)-1H-1,2,4-triazole DMVJZ0C Discovery agent N.A. Investigative [24]
1-(9-Phenyl-9H-fluoren-9-yl)1H-imidazole DMLIJYS Discovery agent N.A. Investigative [8]
1-(9H-fluoren-9-yl)-1H-imidazole DMH49OD Discovery agent N.A. Investigative [24]
1-(biphenyl-3-ylmethyl)-1H-1,2,4-triazole DMGVPMT Discovery agent N.A. Investigative [10]
1-Bromo-4-imidazol-1-ylmethyl-xanthen-9-one DMGL4MJ Discovery agent N.A. Investigative [30]
1-Ethyl-5-(imidazol-1-yl-phenyl-methyl)-1H-indole DMUOSJG Discovery agent N.A. Investigative [31]
1-Imidazol-1-ylmethyl-4-nitro-xanthen-9-one DMN7KHS Discovery agent N.A. Investigative [30]
1-Imidazol-1-ylmethylxanthen-9-one DMIDX7P Discovery agent N.A. Investigative [25]
1-Naphthalen-2-yl-1H-imidazole DMTBZJL Discovery agent N.A. Investigative [26]
1-[(7-Fluoronaphth-2-yl)methyl]-1H-imidazole DMNJMGK Discovery agent N.A. Investigative [8]
10-EPI-8-DEOXY-CUMAMBRIN B DMDQ7Z9 Discovery agent N.A. Investigative [8]
11BETA,13-DIHYDRO-10-EPI-8-DEOXYCUMAM-BRIN B DM0EPJT Discovery agent N.A. Investigative [8]
2,3,4-Trimethoxy-4'-amino-trans-stilbene DMPRF1X Discovery agent N.A. Investigative [27]
2,3,5-Trimethoxy-4'-amino-trans-stilbene DMLI5UT Discovery agent N.A. Investigative [27]
2,3-Dimethoxy-4'-amino-trans-stilbene DM9C0YZ Discovery agent N.A. Investigative [27]
2,4-Dimethoxy-3'-amino-trans-stilbene DMHSLXI Discovery agent N.A. Investigative [27]
2,4-Dimethoxy-4'-amino-trans-stilbene DMMZ643 Discovery agent N.A. Investigative [27]
2,5-Dimethoxy-4'-amino-trans-stilbene DMV0UIR Discovery agent N.A. Investigative [27]
2-(1H-Imidazol-1-yl)-1-(4-nitrophenyl)ethanone DMFK9GA Discovery agent N.A. Investigative [27]
2-(3-hydroxyphenyl)-7-methoxychroman-4-one DMAH0ZG Discovery agent N.A. Investigative [21]
2-(4-hydroxyphenyl)-7-methoxychroman-4-one DMT847Y Discovery agent N.A. Investigative [21]
2-Imidazol-1-yl-7-methoxy-3-phenyl-chromen-4-one DM261B0 Discovery agent N.A. Investigative [32]
2-Imidazol-1-ylmethylxanthen-9-one DM2GUDZ Discovery agent N.A. Investigative [25]
2-phenyl-2,3-dihydrobenzo[h]chromen-4-one DMRNZ4X Discovery agent N.A. Investigative [21]
2-Phenyl-3-pyridin-4-ylmethylene-chroman-4-one DMKCOS2 Discovery agent N.A. Investigative [33]
2-Phenyl-4-[1,2,4]triazol-1-yl-chroman-7-ol DMEXYSP Discovery agent N.A. Investigative [29]
3,4'-(Ethane-1,2-diyl)dibenzenamine DMFM60H Discovery agent N.A. Investigative [27]
3,4,5-Trimethoxy-3'-amino-trans-stilbene DMCA7XU Discovery agent N.A. Investigative [27]
3,4,5-Trimethoxy-4'-amino-trans-stilbene DMDBOJ5 Discovery agent N.A. Investigative [27]
3,4-bis(3,4-dimethoxyphenyl)furan-2(5H)-one DM91W2K Discovery agent N.A. Investigative [8]
3,4-Dimethoxy-4'-amino-trans-stilbene DMVDZCE Discovery agent N.A. Investigative [27]
3,5-Diacetoxy-4'-amino-trans-stilbene DMEXPIJ Discovery agent N.A. Investigative [27]
3,5-Diamino-4'-amino-trans-stilbene DMK9JCA Discovery agent N.A. Investigative [27]
3,5-Dihydroxyl-4'-amino-trans-stilbene DMQ9TNB Discovery agent N.A. Investigative [27]
3,5-Dimethoxy-4'-amino-trans-stilbene DMC3917 Discovery agent N.A. Investigative [27]
3-((1H-imidazol-1-yl)methyl)-9H-xanthen-9-one DM491YV Discovery agent N.A. Investigative [25]
3-(1-ethyl-3,4-dihydronaphthalen-2-yl)-pyridine DMR7M82 Discovery agent N.A. Investigative [34]
3-(1-methyl-3,4-dihydronaphthalen-2-yl)-pyridine DMU5HMC Discovery agent N.A. Investigative [34]
3-(2,2-Diphenyl-vinyl)-pyridine DMCPOQ9 Discovery agent N.A. Investigative [35]
3-(3,4-dihydronaphthalen-2-yl)pyridine DM0VL17 Discovery agent N.A. Investigative [34]
3-(3-methyl-3,4-dihydronaphthalen-2-yl)pyridine DM2YLBD Discovery agent N.A. Investigative [34]
3-(4-Amino-phenyl)-1-methyl-pyrrolidine-2,5-dione DMS1LDH Discovery agent N.A. Investigative [36]
3-(4-Amino-phenyl)-3-butyl-piperidine-2,6-dione DMD5YKO Discovery agent N.A. Investigative [37]
3-(4-Amino-phenyl)-3-ethyl-pyrrolidine-2,5-dione DM3I15D Discovery agent N.A. Investigative [36]
3-(4-Amino-phenyl)-3-heptyl-piperidine-2,6-dione DMZ86CS Discovery agent N.A. Investigative [37]
3-(4-Amino-phenyl)-3-hexyl-piperidine-2,6-dione DMW62U8 Discovery agent N.A. Investigative [37]
3-(4-Amino-phenyl)-3-methyl-pyrrolidine-2,5-dione DMITHX5 Discovery agent N.A. Investigative [36]
3-(4-Amino-phenyl)-3-pentyl-piperidine-2,6-dione DM20DXS Discovery agent N.A. Investigative [37]
3-(4-Amino-phenyl)-3-propyl-piperidine-2,6-dione DM39XMT Discovery agent N.A. Investigative [37]
3-(4-Amino-phenyl)-pyrrolidine-2,5-dione DMVN0O5 Discovery agent N.A. Investigative [36]
3-(4-methyl-3,4-dihydronaphthalen-2-yl)pyridine DMDR20P Discovery agent N.A. Investigative [34]
3-(5-Bromo-6-methoxy-naphthalen-2-yl)-pyridine DMUIXNS Discovery agent N.A. Investigative [26]
3-(5-Chloro-6-methoxy-naphthalen-2-yl)-pyridine DM67DVU Discovery agent N.A. Investigative [26]
3-(6-Ethoxy-naphthalen-2-yl)-pyridine DMUQ0WI Discovery agent N.A. Investigative [26]
3-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine DMAJHXO Discovery agent N.A. Investigative [34]
3-(6-methoxynaphthalen-2-yl)pyridine DMYRJAB Discovery agent N.A. Investigative [38]
3-(imidazolylmethyl)-4'-methoxyflavone DMM52LC Discovery agent N.A. Investigative [39]
3-(imidazolylmethyl)-4'-nitroflavone DMX2LT5 Discovery agent N.A. Investigative [39]
3-(imidazolylmethyl)-7-methoxy-4'-nitroflavone DML63MX Discovery agent N.A. Investigative [39]
3-(imidazolylmethyl)flavone DMLI7F4 Discovery agent N.A. Investigative [39]
3-(naphthalen-2-yl)pyridine DMJRBT1 Discovery agent N.A. Investigative [38]
3-Amino-4'-amino-trans-stilbene DMIS3LN Discovery agent N.A. Investigative [27]
3-Fluoren-9-ylidenemethyl-pyridine DMR29IQ Discovery agent N.A. Investigative [35]
3-Fluoro-4'-(pyridin-4-ylmethyl)biphenyl-4-ol DMJ3WNP Discovery agent N.A. Investigative [40]
3-Indan-(1E)-ylidenemethyl-pyridine DMYH6A2 Discovery agent N.A. Investigative [35]
3-Indan-(1Z)-ylidenemethyl-pyridine DMTQERW Discovery agent N.A. Investigative [35]
3-Methoxyl-4'-amino-trans-stilbene DMWNO4D Discovery agent N.A. Investigative [27]
3-Nitro-4'-nitro-trans-stilbene DMZRNOT Discovery agent N.A. Investigative [27]
3-[3-Methyl-indan-(1E)-ylidenemethyl]-pyridine DMDS8UJ Discovery agent N.A. Investigative [35]
3-[3-Methyl-indan-(1Z)-ylidenemethyl]-pyridine DMTF520 Discovery agent N.A. Investigative [35]
3-[3-Phenyl-indan-(1E)-ylidenemethyl]-pyridine DMYEWA4 Discovery agent N.A. Investigative [35]
3-[4-Chloro-indan-(1E)-ylidenemethyl]-pyridine DM0XD6T Discovery agent N.A. Investigative [35]
3-[4-Chloro-indan-(1Z)-ylidenemethyl]-pyridine DMMDIB9 Discovery agent N.A. Investigative [35]
3-[4-Fluoro-indan-(1E)-ylidenemethyl]-pyridine DMZS20Y Discovery agent N.A. Investigative [35]
3-[4-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine DMPS340 Discovery agent N.A. Investigative [35]
3-[4-Methyl-indan-(1E)-ylidenemethyl]-pyridine DMJN93U Discovery agent N.A. Investigative [35]
3-[4-Methyl-indan-(1Z)-ylidenemethyl]-pyridine DMNILXG Discovery agent N.A. Investigative [35]
3-[5-Bromo-indan-(1E)-ylidenemethyl]-pyridine DMUEVAQ Discovery agent N.A. Investigative [35]
3-[5-Bromo-indan-(1Z)-ylidenemethyl]-pyridine DMCXSIH Discovery agent N.A. Investigative [35]
3-[5-Chloro-indan-(1E)-ylidenemethyl]-pyridine DM8TWLO Discovery agent N.A. Investigative [35]
3-[5-Chloro-indan-(1Z)-ylidenemethyl]-pyridine DMN60YG Discovery agent N.A. Investigative [35]
3-[5-Ethoxy-indan-(1E)-ylidenemethyl]-pyridine DMLJQZS Discovery agent N.A. Investigative [35]
3-[5-Ethoxy-indan-(1Z)-ylidenemethyl]-pyridine DMMTUON Discovery agent N.A. Investigative [35]
3-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyridine DMWSFIR Discovery agent N.A. Investigative [35]
3-[5-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine DMN42I5 Discovery agent N.A. Investigative [35]
3-[5-Methoxy-indan-(1E)-ylidenemethyl]-pyridine DM9AW5U Discovery agent N.A. Investigative [35]
3-[5-Methoxy-indan-(1Z)-ylidenemethyl]-pyridine DMB3XYE Discovery agent N.A. Investigative [35]
3-[6-Methoxy-indan-(1E)-ylidenemethyl]-pyridine DMHT6FX Discovery agent N.A. Investigative [35]
3-[6-Methyl-indan-(1E)-ylidenemethyl]-pyridine DMG76LS Discovery agent N.A. Investigative [35]
3-[6-Methyl-indan-(1Z)-ylidenemethyl]-pyridine DMKOB2T Discovery agent N.A. Investigative [35]
3-[7-Methoxy-indan-(1E)-ylidenemethyl]-pyridine DMVWIQ2 Discovery agent N.A. Investigative [35]
4'-(Pyridin-4-ylmethyl)biphenyl-3,4-diol DM6Z5EK Discovery agent N.A. Investigative [40]
4'-(Pyridin-4-ylmethyl)biphenyl-3-amine DMR8O1B Discovery agent N.A. Investigative [40]
4'-bromo-3-(imidazolylmethyl)-7-methoxyflavone DMK2PBJ Discovery agent N.A. Investigative [39]
4'-bromo-3-(imidazolylmethyl)flavone DM2V3S8 Discovery agent N.A. Investigative [39]
4'-cyano-3-(imidazolylmethyl)-7-methoxyflavone DMWGF9R Discovery agent N.A. Investigative [39]
4'-cyano-3-(imidazolylmethyl)flavone DMUJS4R Discovery agent N.A. Investigative [39]
4-((1H-imidazol-1-yl)methyl)-2H-chromen-2-one DMDHV0N Discovery agent N.A. Investigative [24]
4-((1H-imidazol-1-yl)methyl)benzonitrile DMFUBRC Discovery agent N.A. Investigative [28]
4-(1-Imidazol-1-yl-vinyl)-benzonitrile DM08963 Discovery agent N.A. Investigative [41]
4-(2,2-Diphenyl-vinyl)-pyridine DMI638K Discovery agent N.A. Investigative [35]
4-(2-(1H-imidazol-1-yl)ethoxy)-2H-chromen-2-one DM1043B Discovery agent N.A. Investigative [24]
4-(3,4,5-Trimethoxyphenethyl)aniline DMNUWK2 Discovery agent N.A. Investigative [27]
4-(3,4-Dimethoxyphenethyl)aniline DMBI7MS Discovery agent N.A. Investigative [27]
4-(3,5-Dimethoxyphenethyl)benzenamine DM4FC9O Discovery agent N.A. Investigative [27]
4-ANDROSTENE-3-17-DIONE DMSE8NU Discovery agent N.A. Investigative [42], [43]
4-Bromo-1-imidazol-1-ylmethyl-xanthen-9-one DMMVASI Discovery agent N.A. Investigative [30]
4-Fluoren-9-ylidenemethyl-pyridine DMW9I1X Discovery agent N.A. Investigative [35]
4-Imidazol-1-yl-2-phenyl-chroman-7-ol DMJKF17 Discovery agent N.A. Investigative [29]
4-Imidazol-1-ylmethyl-1-nitro-xanthen-9-one DMZLVIF Discovery agent N.A. Investigative [30]
4-Imidazol-1-ylmethyl-1-nitrothioxanthen-9-one DM28DEU Discovery agent N.A. Investigative [25]
4-Imidazol-1-ylmethyl-2-nitroxanthen-9-one DM6FMO1 Discovery agent N.A. Investigative [25]
4-Imidazol-1-ylmethyl-3-nitroxanthen-9-one DM8KZQN Discovery agent N.A. Investigative [25]
4-Imidazol-1-ylmethylthioxanthen-9-one DMVUSMP Discovery agent N.A. Investigative [25]
4-Imidazol-1-ylmethylxanthen-9-one DMM8HK0 Discovery agent N.A. Investigative [25]
4-Indan-(1E)-ylidenemethyl-pyridine DMFRCQS Discovery agent N.A. Investigative [35]
4-Indan-(1Z)-ylidenemethyl-pyridine DM25DR7 Discovery agent N.A. Investigative [35]
4-[(3'-Hydroxybiphenyl-4-yl)methyl]pyridine DM04MK7 Discovery agent N.A. Investigative [40]
4-[(4'-Hydroxybiphenyl-4-yl)methyl]pyridine DMIEMWA Discovery agent N.A. Investigative [40]
4-[5-Bromo-indan-(1Z)-ylidenemethyl]-pyridine DMQKHXN Discovery agent N.A. Investigative [35]
4-[5-Chloro-indan-(1E)-ylidenemethyl]-pyridine DMZL8KN Discovery agent N.A. Investigative [35]
4-[5-Chloro-indan-(1Z)-ylidenemethyl]-pyridine DM1Z3DG Discovery agent N.A. Investigative [35]
4-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyridine DMY08FE Discovery agent N.A. Investigative [35]
4-[5-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine DMHDZUO Discovery agent N.A. Investigative [35]
4-[5-Methoxy-indan-(1E)-ylidenemethyl]-pyridine DM25GS6 Discovery agent N.A. Investigative [35]
4-[5-Methoxy-indan-(1Z)-ylidenemethyl]-pyridine DMLBX4Q Discovery agent N.A. Investigative [35]
4-[6-Methoxy-indan-(1E)-ylidenemethyl]-pyridine DM3IR8Y Discovery agent N.A. Investigative [35]
4-[6-Methoxy-indan-(1Z)-ylidenemethyl]-pyridine DMIBZJC Discovery agent N.A. Investigative [35]
4-[6-Methyl-indan-(1E)-ylidenemethyl]-pyridine DMYGN1K Discovery agent N.A. Investigative [35]
4-[6-Methyl-indan-(1Z)-ylidenemethyl]-pyridine DM5VN3D Discovery agent N.A. Investigative [35]
5-((1H-imidazol-1-yl)methyl)-7,8-dihydroquinoline DML4DSG Discovery agent N.A. Investigative [24]
5-(2-(1H-imidazol-1-yl)ethyl)quinoline DMA2GIE Discovery agent N.A. Investigative [24]
5-Bromo-8-imidazol-1-ylmethyl-chromen-4-one DM09Y72 Discovery agent N.A. Investigative [30]
5-Indan-(1E)-ylidenemethyl-1H-imidazole DMW8AOM Discovery agent N.A. Investigative [44]
5-Indan-(1Z)-ylidenemethyl-1H-imidazole DMKLY20 Discovery agent N.A. Investigative [44]
5-Pyridin-3-yl-1,3-dihydro-2H-indol-2-one DMLRM9Z Discovery agent N.A. Investigative [38]
5-Pyridin-3-yl-2,3-dihydro-1H-inden-1-one DMQYIBC Discovery agent N.A. Investigative [38]
5-[5-Bromo-indan-(1E)-ylidenemethyl]-1H-imidazole DMV7QU3 Discovery agent N.A. Investigative [44]
5-[5-Bromo-indan-(1Z)-ylidenemethyl]-1H-imidazole DMZICL8 Discovery agent N.A. Investigative [44]
5-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyrimidine DM2RIHT Discovery agent N.A. Investigative [35]
5-[5-Fluoro-indan-(1Z)-ylidenemethyl]-pyrimidine DMQGX2Z Discovery agent N.A. Investigative [35]
5-[5-Methoxy-indan-(1E)-ylidenemethyl]-thiazole DM5FA74 Discovery agent N.A. Investigative [35]
5-[5-Methoxy-indan-(1Z)-ylidenemethyl]-thiazole DMPDN63 Discovery agent N.A. Investigative [35]
6-((1H-imidazol-1-yl)methyl)-2H-chromene-2-thione DMOR04W Discovery agent N.A. Investigative [24]
6-Imidazol-1-yl-isoquinoline DMQXL1Y Discovery agent N.A. Investigative [24]
7,4'-Dihydroxyflavone DMXQ1K0 Discovery agent N.A. Investigative [8]
7-((1H-imidazol-1-yl)methyl)-2H-chromen-2-one DM2UTEA Discovery agent N.A. Investigative [24]
7-((1H-imidazol-1-yl)methyl)-4H-chromen-4-one DMOS4ZQ Discovery agent N.A. Investigative [24]
7-((1H-imidazol-1-yl)methyl)isoquinoline DM9ID4T Discovery agent N.A. Investigative [24]
7-(2-(1H-imidazol-1-yl)ethoxy)-2H-chromen-2-one DM4HUO1 Discovery agent N.A. Investigative [45]
7-hydroxy-2-(3-hydroxyphenyl)chroman-4-one DMXBUNV Discovery agent N.A. Investigative [21]
7-hydroxy-2-phenylchroman-4-one DM4UW65 Discovery agent N.A. Investigative [21]
7-[1,2,4]Triazol-4-ylmethyl-chromen-4-one DMNGLM1 Discovery agent N.A. Investigative [30]
8-Imidazol-1-ylmethyl-5-nitro-chromen-4-one DMA26L4 Discovery agent N.A. Investigative [30]
9-Hydroxy-7,8-benzoflavone DMH72MU Discovery agent N.A. Investigative [8]
ALBANOL A DMHIW2L Discovery agent N.A. Investigative [22]
Alpha-naphthoflavone DMELOIQ Discovery agent N.A. Investigative [8]
ANDROSTENEDONE DMPL0BA Discovery agent N.A. Investigative [46]
Apigenin DMI3491 Discovery agent N.A. Investigative [8]
Benzyl-biphenyl-4-ylmethyl-imidazol-1-yl-amine DMFB4M5 Discovery agent N.A. Investigative [23]
biochanin A DM0HPWY Discovery agent N.A. Investigative [8]
Broussoflavonol F DMB9SEI Discovery agent N.A. Investigative [22]
CGS-18320B DM2CS5A Discovery agent N.A. Investigative [8]
Chrysin DM7V2LG Discovery agent N.A. Investigative [8]
DEHYDROLEUCODIN DM0V1NH Discovery agent N.A. Investigative [8]
Docosapentaenoic acid DMVCP6X Discovery agent N.A. Investigative [47]
Flavone DMEQH6J Discovery agent N.A. Investigative [8]
Gamma-mangostin DMC0OVP Discovery agent N.A. Investigative [48]
GARCINONE D DMQDV3U Discovery agent N.A. Investigative [48]
GOSSYPETIN DMMT05U Discovery agent N.A. Investigative [49]
Isogemichalcone C DM31AXO Discovery agent N.A. Investigative [22]
ISOLICOFLAVONOL DMYEGBC Discovery agent N.A. Investigative [22]
LIQUIRTIGENIN DM6YSG3 Discovery agent N.A. Investigative [49]
LUDARTIN DMI9VNO Discovery agent N.A. Investigative [8]
MDL-18962 DMTVOWC Discovery agent N.A. Investigative [50]
MONODICTYOCHROMONE B DM59CR0 Discovery agent N.A. Investigative [51]
MORACHALCONE A DMWR0J1 Discovery agent N.A. Investigative [22]
MR-16089 DMM2WG7 Discovery agent N.A. Investigative [8]
MR-20492 DMEBQLK Discovery agent N.A. Investigative [8]
MR-20494 DMC79YF Discovery agent N.A. Investigative [8]
MR-20496 DMTCG8M Discovery agent N.A. Investigative [52]
MR-20814 DMSR3OI Discovery agent N.A. Investigative [52]
N-(2-benzyloxy-4-nitrophenyl)methanesulfonamide DMW5XLG Discovery agent N.A. Investigative [53]
N-(2-hexyloxy-4-nitrophenyl)methanesulfonamide DM27L53 Discovery agent N.A. Investigative [54]
N-(2-nonyloxy-4-nitrophenyl)methanesulfonamide DMU6FPL Discovery agent N.A. Investigative [54]
N-(2-Propyloxy-4-nitrophenyl)methanesulfonamide DMAQMXJ Discovery agent N.A. Investigative [54]
N-[2-(4'-Nitrophenyl)ethyl]-imidazole DMPKBT1 Discovery agent N.A. Investigative [8]
NSC-122427 DMYMB4A Discovery agent N.A. Investigative [55]
NSC-12999 DMJAO6Z Discovery agent N.A. Investigative [24]
NSC-131736 DMYJNS9 Discovery agent N.A. Investigative [24]
NSC-289311 DMZU1L0 Discovery agent N.A. Investigative [24]
NSC-356483 DMEK5B2 Discovery agent N.A. Investigative [24]
NSC-356781 DM9LI7M Discovery agent N.A. Investigative [24]
NSC-368272 DMR97X3 Discovery agent N.A. Investigative [24]
NSC-368280 DMR3IP5 Discovery agent N.A. Investigative [24]
NSC-369087 DMAQWM8 Discovery agent N.A. Investigative [24]
NSC-613604 DMD1XM0 Discovery agent N.A. Investigative [55]
NSC-625409 DM0GWAC Discovery agent N.A. Investigative [24]
NSC-666292 DMNMF0C Discovery agent N.A. Investigative [24]
NSC-683634 DMZ2KUB Discovery agent N.A. Investigative [24]
NSC-75308 DM8GZAM Discovery agent N.A. Investigative [24]
NSC-93358 DMTOFS7 Discovery agent N.A. Investigative [55]
NSC-94258 DM6VY3P Discovery agent N.A. Investigative [8]
NSC-94891 DM31CZK Discovery agent N.A. Investigative [55]
Org-33201 DMDY38R Discovery agent N.A. Investigative [56]
⏷ Show the Full List of 220 Investigative Drug(s)

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