Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DEV3T4A)

DME Name	Catechol O-methyltransferase (COMT) DME Info
UniProt ID	COMT_HUMAN
Gene Name	COMT

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Approved Drug(s)

Investigative Drug(s)

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3 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dobutamine	DMD1B8Z	Heart failure	BD10-BD13	Approved	[1]
Dopamine	DMPGUCF	Parkinson disease	8A00.0	Approved	[2]
Epinephrine	DM3KJBC	Allergy	4A80-4A85	Approved	[3]
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1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylenedioxymethamphetamine	DMYVU47	Discovery agent	N.A.	Investigative	[4]
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Molecule Interaction Atlas

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References

1	Catechol-O-methyltransferase: substrate-specificity and stereoselectivity for beta-adrenoceptor agents. Xenobiotica. 1986 Jan;16(1):47-52.
2	Association between polymorphisms in catechol-O-methyltransferase (COMT) and cocaine-induced paranoia in European-American and African-American populations. Am J Med Genet B Neuropsychiatr Genet. 2011 Sep;156B(6):651-60.
3	Different metabolism of norepinephrine and epinephrine by catechol-O-methyltransferase and monoamine oxidase in rats. J Pharmacol Exp Ther. 1994 Mar;268(3):1242-51.
4	Human pharmacology of MDMA: pharmacokinetics, metabolism, and disposition. Ther Drug Monit. 2004 Apr;26(2):137-44.