Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DEZV4AP)

• DME Name: RNA cytidine acetyltransferase (hALP) DME Info
• Gene Name: NAT10

Molecule-Related Drug & Molecule List

14 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Allopurinol	DMLPAOB	Gout	FA25	Approved	[1]
Arbekacin	DMHTXSL	Bacterial infection	1A00-1C4Z	Approved	[2]
Caffeine	DMKBJWP	Allergic rhinitis	CA08.0	Approved	[3]
Clonazepam	DMTO13J	Absence epilepsy		Approved	[4]
Dihydralazine	DMZIXU9	Hypertension	BA00-BA04	Approved	[5]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[6]
Hydralazine	DMU8JGH	Chronic heart failure	BD1Z	Approved	[7]
Mesalazine	DMOL5IU	Diverticulitis		Approved	[8]
Netilmicin	DMRD1QK	Bacterial infection	1A00-1C4Z	Approved	[9]
Procainamide	DMNMXR8	Ventricular arrhythmias	BC71	Approved	[10]
Sulfadiazine	DMTW3R8	Rheumatic fever	1B40-1B42	Approved	[11]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[12]
Sulfapyridine	DMIUYFH	Dermatitis herpetiformis	EB44	Approved	[13]
Tobramycin	DMUI0CH	Bacteremia	1A73	Approved	[14]

2 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metamizole	DM79GRO	Fever	MG26	Withdrawn from market	[15]
Octopamine	DMLQVTJ	Thrombosis	DB61-GB90	Discontinued in Phase 2a	[16]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aminobenzoic acid	DMNGW2M	N. A.	N. A.	Investigative	[17]
Phenazone	DMCE985	Discovery agent	N.A.	Investigative	[18]

References

• [1] Xanthine oxidase inhibition by allopurinol affects the reliability of urinary caffeine metabolic ratios as markers for N-acetyltransferase 2 and CYP1A2 activities. Eur J Clin Pharmacol. 1999 Jan;54(11):869-76.
• [2] The novel enzymatic 3''-N-acetylation of arbekacin by an aminoglycoside 3-N-acetyltransferase of Streptomyces origin and the resulting activity. J Antibiot (Tokyo). 1998 Aug;51(8):735-42.
• [3] A population and family study of N-acetyltransferase using caffeine urinary metabolites. Clin Pharmacol Ther. 1993 Aug;54(2):134-41.
• [4] Effect of common NAT2 variant alleles in the acetylation of the major clonazepam metabolite, 7-aminoclonazepam. Drug Metab Lett. 2007 Jan;1(1):3-5.
• [5] The influence of the acetylator phenotype for the clinical use of dihydralazine. Int J Clin Pharmacol Ther Toxicol. 1985 Apr;23 Suppl 1:S74-8.
• [6] Arylamine N-acetyltransferase in human red blood cells. Biochem Pharmacol. 1992 Sep 25;44(6):1099-104.
• [7] Prizidilol, an antihypertensive with precapillary vasodilator and beta-adrenoceptor blocking actions, in primary hypertension. Clin Pharmacol Ther. 1981 May;29(5):588-93.
• [8] NAT1 genotypes do not predict response to mesalamine in patients with ulcerative colitis. Z Gastroenterol. 2008 Mar;46(3):259-65.
• [9] Aminoglycoside resistance resulting from tight drug binding to an altered aminoglycoside acetyltransferase. Antimicrob Agents Chemother. 2003 May;47(5):1577-83.
• [10] Effect of H2-receptor antagonists on rat liver cytosolic acetyl CoA:arylamine N-acetyltransferase activity. Drug Metab Dispos. 1992 Jan-Feb;20(1):74-8.
• [11] Identification of cytochrome P450 and arylamine N-acetyltransferase isoforms involved in sulfadiazine metabolism. Drug Metab Dispos. 2005 Jul;33(7):969-76.
• [12] Crystallization and preliminary X-ray characterization of arylamine N-acetyltransferase C (BanatC) from Bacillus anthracis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Oct 1;63(Pt 10):862-4.
• [13] Effects of NAT2 polymorphism on SASP pharmacokinetics in Chinese population. Clin Chim Acta. 2009 Sep;407(1-2):30-5.
• [14] Genetic analysis of bacterial acetyltransferases: identification of amino acids determining the specificities of the aminoglycoside 6'-N-acetyltransferase Ib and IIa proteins. J Bacteriol. 1992 May;174(10):3196-203.
• [15] N-acetyltransferase 2 polymorphisms and susceptibility to infant leukemia with maternal exposure to dipyrone during pregnancy. Cancer Epidemiol Biomarkers Prev. 2010 Dec;19(12):3037-43.
• [16] [N-acetylation of biogenic amines in Drosophila virilis]. Genetika. 1997 Jun;33(6):788-92.
• [17] Leukemia inhibitory factor decreases the arylamine N-acetyltransferase activity in human cumulus granulosa cells. J Assist Reprod Genet. 2001 Dec;18(12):660-4.
• [18] Evaluation of the influence of diabetes mellitus on antipyrine metabolism and CYP1A2 and CYP2D6 activity. Pharmacotherapy. 2000 Feb;20(2):182-90.