Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTP (ID: DT2EG60)

• DTP Name: Organic cation/carnitine transporter 1 (SLC22A4) DTP Info
• Gene Name: OCTN1

Molecule-Related Drug & Molecule List

6 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[1]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[2]
Ipratropium	DMFQ320	Obstructive lung disease	CA22.Z	Approved	[3]
Levacecarnine hci	DMJBOCR	Cognitive impairment	6D71	Approved	[4]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[5]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[5]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
[14C]TEA	DM6SFYH	Discovery agent	N.A.	Investigative	[6]

References

• [1] OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues. Cancer Res. 2017 Apr 15;77(8):2102-2111.
• [2] Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin. Clin Pharmacol Ther. 2008 Mar;83(3):416-21.
• [3] Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption. Mol Pharm. 2010 Feb 1;7(1):187-95.
• [4] Spontaneous development of intestinal and colonic atrophy and inflammation in the carnitine-deficient jvs (OCTN2(-/-)) mice. Mol Genet Metab. 2007 Dec;92(4):315-24.
• [5] Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73.
• [6] Functional effects of protein sequence polymorphisms in the organic cation/ergothioneine transporter OCTN1 (SLC22A4). Pharmacogenet Genomics. 2007 Sep;17(9):773-82.