Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTP (ID: DT3BA8L)

DTP Name	Sodium-dependent dopamine transporter (SLC6A3) DTP Info
UniProt ID	SC6A3_HUMAN
Gene Name	DAT1

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Approved Drug(s)

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5 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphetamine	DMSZQAK	Attention deficit hyperactivity disorder	6A05.Z	Approved	[1]
Benztropine	DMGZOVN	Parkinson disease	8A00.0	Approved	[2]
Bretylium	DM1FX74	Ventricular fibrillation	BC71.1	Approved	[3]
Dopamine	DMPGUCF	Parkinson disease	8A00.0	Approved	[4]
OPC-34712	DMHG57U	Major depressive disorder	6A70.3	Approved	[5]
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Molecule Interaction Atlas

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References

1	Amphetamines, new psychoactive drugs and the monoamine transporter cycle. Trends Pharmacol Sci. 2015 Jan;36(1):41-50.
2	Pharmacological characterization of a dopamine transporter ligand that functions as a cocaine antagonist. J Pharmacol Exp Ther. 2014 Jan;348(1):106-15.
3	Which form of dopamine is the substrate for the human dopamine transporter: the cationic or the uncharged species? J Biol Chem. 1999 Feb 19;274(8):4876-82.
4	Characterization of VNTRs Within the Entire Region of SLC6A3 and Its Association with Hypertension. DNA Cell Biol. 2017 Mar;36(3):227-236.
5	Brexpiprazole reduces hyperactivity, impulsivity, and risk-preference behavior in mice with dopamine transporter knockdown-a model of mania. Psychopharmacology (Berl). 2017 Mar;234(6):1017-1028.