General Information of DTP (ID: DT3TX4H)

DTP Name Multidrug and toxin extrusion protein 2 (SLC47A2) DTP Info
Gene Name MATE2

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Approved Drug(s)
Preclinical Drug(s)
Investigative Drug(s)
9 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aciclovir DMYLOVR Genital herpes 1A94 Approved [1]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [1]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [2]
Estrone sulfate DMVBIZL Atrophic vaginitis GA30.2 Approved [1]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [1]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [3]
Metformin DM89QE1 Colorectal carcinoma Approved [1]
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [1]
Topotecan DMP6G8T Central nervous system neoplasm Approved [1]
------------------------------------------------------------------------------------
⏷ Show the Full List of 9 Approved Drug(s)
1 Preclinical Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
N-methylpyridinium DMVUKEW N. A. N. A. Preclinical [1]
------------------------------------------------------------------------------------
1 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
[14C]TEA DM6SFYH Discovery agent N.A. Investigative [1]
------------------------------------------------------------------------------------
Molecule Interaction Atlas

References

1 Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71.
2 FDA Drug Development and Drug Interactions
3 Abemaciclib Inhibits Renal Tubular Secretion Without Changing Glomerular Filtration Rate. Clin Pharmacol Ther. 2019 May;105(5):1187-1195.