General Information of DTP (ID: DTYVM24)

DTP Name Multidrug resistance-associated protein 5 (ABCC5) DTP Info
Gene Name MRP5

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Approved Drug(s)
Investigative Drug(s)
10 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [1]
FLUORESCEIN DMQTFAO Ocular disease 1F00.1Z Approved [2]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [3]
Folic Acid DMEMBJC Colorectal carcinoma Approved [4]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [5]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [6]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [7]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [8]
Methotrexate DM2TEOL Anterior urethra cancer Approved [4]
Pemetrexed DMMX2E6 Central nervous system lymphoma 2B33.5 Approved [9]
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⏷ Show the Full List of 10 Approved Drug(s)
2 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carboxydichlorofluorescein DMTAYMR N. A. N. A. Investigative [9]
[3H]cAMP DMZRQU7 Discovery agent N.A. Investigative [10]
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Molecule Interaction Atlas

References

1 Role of MRP4 and MRP5 in biology and chemotherapy. AAPS PharmSci. 2002;4(3):E14.
2 Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP. J Biol Chem. 2007 Jul 20;282(29):20999-1004.
3 ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44.
4 The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates. Cancer Res. 2005 May 15;65(10):4425-30.
5 Cellular export of drugs and signaling molecules by the ATP-binding cassette transporters MRP4 (ABCC4) and MRP5 (ABCC5). Drug Metab Rev. 2005;37(1):253-78.
6 Interdependence of gemcitabine treatment, transporter expression, and resistance in human pancreatic carcinoma cells. Neoplasia. 2010 Sep;12(9):740-7.
7 Celecoxib upregulates multidrug resistance proteins in colon cancer: lack of synergy with standard chemotherapy. Curr Cancer Drug Targets. 2008 Aug;8(5):414-20.
8 Overexpression of MRP4 (ABCC4) and MRP5 (ABCC5) confer resistance to the nucleoside analogs cytarabine and troxacitabine, but not gemcitabine. Springerplus. 2014 Dec 13;3:732.
9 Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport. Eur J Pharm Sci. 2006 Apr;27(5):524-32.
10 The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. J Biol Chem. 2000 Sep 29;275(39):30069-74.