Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTP (ID: DTYVM24)

• DTP Name: Multidrug resistance-associated protein 5 (ABCC5) DTP Info
• UniProt ID: MRP5_HUMAN
• Gene Name: MRP5

Molecule-Related Drug & Molecule List

10 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[1]
Fluorescein	DMQTFAO	Ocular disease	1F00.1Z	Approved	[2]
Fluorouracil	DMUM7HZ	Solid tumour/cancer	2A00-2F9Z	Approved	[3]
Folic acid	DMEMBJC	Folate-deficiency anemia	3A02.Y	Approved	[4]
Ganciclovir	DM1MBYQ	Virus infection	1A24-1D9Z	Approved	[5]
Gemcitabine	DMSE3I7	Solid tumour/cancer	2A00-2F9Z	Approved	[6]
Irinotecan	DMP6SC2	Colorectal cancer	2B91.Z	Approved	[7]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[8]
Methotrexate	DM2TEOL	leukaemia	2A60-2B33	Approved	[4]
Pemetrexed	DMMX2E6	Malignant pleural mesothelioma	2C26.0	Approved	[9]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carboxydichlorofluorescein	DMTAYMR	Discovery agent	N.A.	Investigative	[9]
[3H]cAMP	DMZRQU7	Discovery agent	N.A.	Investigative	[10]

References

• [1] Role of MRP4 and MRP5 in biology and chemotherapy. AAPS PharmSci. 2002;4(3):E14.
• [2] Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP. J Biol Chem. 2007 Jul 20;282(29):20999-1004.
• [3] ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44.
• [4] The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates. Cancer Res. 2005 May 15;65(10):4425-30.
• [5] Cellular export of drugs and signaling molecules by the ATP-binding cassette transporters MRP4 (ABCC4) and MRP5 (ABCC5). Drug Metab Rev. 2005;37(1):253-78.
• [6] Interdependence of gemcitabine treatment, transporter expression, and resistance in human pancreatic carcinoma cells. Neoplasia. 2010 Sep;12(9):740-7.
• [7] Celecoxib upregulates multidrug resistance proteins in colon cancer: lack of synergy with standard chemotherapy. Curr Cancer Drug Targets. 2008 Aug;8(5):414-20.
• [8] Overexpression of MRP4 (ABCC4) and MRP5 (ABCC5) confer resistance to the nucleoside analogs cytarabine and troxacitabine, but not gemcitabine. Springerplus. 2014 Dec 13;3:732.
• [9] Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport. Eur J Pharm Sci. 2006 Apr;27(5):524-32.
• [10] The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. J Biol Chem. 2000 Sep 29;275(39):30069-74.