Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT1Q3IE)

• DTT Name: Retinoic acid receptor gamma (RARG) DTT Info
• Gene Name: RARG

Molecule-Related Drug & Molecule List

5 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[1]
Palovarotene	DMAD2OZ	Fibrodysplasia ossificans progressiva	FB31.1	Approved	[2]
Tazarotene	DM8SMD1	Acne vulgaris	ED80	Approved	[3]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Trifarotene	DMOL793	Acne vulgaris	ED80	Approved	[5]

6 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID27336223-Compound-11	DMBN6KU	N. A.	N. A.	Patented	[6]
PMID27336223-Compound-12	DMT4P7K	N. A.	N. A.	Patented	[6]
PMID27336223-Compound-13	DMSZLYD	N. A.	N. A.	Patented	[6]
PMID27336223-Compound-14	DMC41MA	N. A.	N. A.	Patented	[6]
PMID27336223-Compound-15	DMIYCFE	N. A.	N. A.	Patented	[6]
PMID27336223-Compound-9	DM6V13W	N. A.	N. A.	Patented	[6]

10 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AGN193109	DMC0YOE	Discovery agent	N.A.	Investigative	[7]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[8]
BMS184394	DMGE82R	Discovery agent	N.A.	Investigative	[9]
BMS270394	DM82SJP	Discovery agent	N.A.	Investigative	[10]
CD2665	DM05M9X	Discovery agent	N.A.	Investigative	[11]
CD564	DMZ2LPO	Discovery agent	N.A.	Investigative	[9]
CD666	DMC8X9Y	Discovery agent	N.A.	Investigative	[12]
Dodecyl-Alpha-D-Maltoside	DMMDG92	Discovery agent	N.A.	Investigative	[13]
MM 11253	DMT1NP8	Discovery agent	N.A.	Investigative	[14]
SR11254	DMBA297	Discovery agent	N.A.	Investigative	[9]

References

• [1] Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):30-4.
• [2] Randomised controlled trial for emphysema with a selective agonist of the gamma-type retinoic acid receptor. Eur Respir J. 2012 Aug;40(2):306-12.
• [3] Recent developments in receptor-selective retinoids. Curr Pharm Des. 2000 Jun;6(9):919-31.
• [4] Targacept active conformation search: a new method for predicting the conformation of a ligand bound to its protein target. J Med Chem. 2004 Dec 30;47(27):6831-9.
• [5] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
• [6] Therapeutic use of selective synthetic ligands for retinoic acid receptors: a patent review.Expert Opin Ther Pat. 2016 Aug;26(8):957-71.
• [7] Therapeutic applications for ligands of retinoid receptors. Curr Pharm Des. 2000 Jan;6(1):25-58.
• [8] Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes. J Med Chem. 1995 Dec 22;38(26):4993-5006.
• [9] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [10] Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARgamma. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6322-7.
• [11] Induction of apoptosis by retinoids and retinoic acid receptor gamma-selective compounds in mouse thymocytes through a novel apoptosis pathway. Mol Pharmacol. 1997 Jun;51(6):972-82.
• [12] Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma. Biochem Biophys Res Commun. 1992 Jul 31;186(2):977-83.
• [13] DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
• [14] Modulation of retinoic acid receptor function alters the growth inhibitory response of oral SCC cells to retinoids. Oncogene. 2000 Mar 9;19(11):1457-65.