Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT32NQ1)

• DTT Name: Short transient receptor potential channel 5 (TRPC5) DTT Info
• Gene Name: TRPC5

Molecule-Related Drug & Molecule List

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BI 1358894	DM740BS	Depression	6A70-6A7Z	Phase 2	[1]
GFB-887	DM2IJWG	Diabetic nephropathy	GB61.Z	Phase 2	[2]

8 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(-)-englerin A	DMPQBWY	Discovery agent	N.A.	Investigative	[3]
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[4]
bromoenol lactone	DMKQ0CA	Discovery agent	N.A.	Investigative	[5]
BTP2	DMNM63G	Discovery agent	N.A.	Investigative	[6]
daidzein	DMRFTJX	Discovery agent	N.A.	Investigative	[6]
KB-R7943	DMMD5W3	Discovery agent	N.A.	Investigative	[7]
lysophosphatidylcholine	DMOGFVH	Discovery agent	N.A.	Investigative	[6]
ML204	DM15YL0	Discovery agent	N.A.	Investigative	[8]

References

• [1] Clinical pipeline report, company report or official report of Boehringer Ingelheim.
• [2] Safety and Efficacy of GFB-887, a TRPC5 Channel Inhibitor, in Patients With Focal Segmental Glomerulosclerosis, Treatment-Resistant Minimal Change Disease, or Diabetic Nephropathy: TRACTION-2 Trial Design. Kidney Int Rep. 2021 Jul 23;6(10):2575-2584.
• [3] (-)-Englerin is a potent and selective activator of TRPC4 and TRPC5 calcium channels. Angew Chem Int Ed Engl. 2015 Mar 16;54(12):3787-91.
• [4] Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect. Br J Pharmacol. 2005 Jun;145(4):405-14.
• [5] Bromoenol lactone inhibits voltage-gated Ca2+ and transient receptor potential canonical channels. J Pharmacol Exp Ther. 2011 Nov;339(2):329-40.
• [6] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 490).
• [7] The Na+/Ca2+ exchange inhibitor KB-R7943 potently blocks TRPC channels. Biochem Biophys Res Commun. 2007 Sep 14;361(1):230-6.
• [8] Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. J Biol Chem. 2011 Sep 23;286(38):33436-46.