Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT3YGCD)

• DTT Name: Bacterial Protective antigen (Bact pagA) DTT Info
• Gene Name: Bact pagA

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Raxibacumab	DM7QG0M	Anthrax	1B97	Approved	[1]

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AVP-21D9	DMMWEH6	Bacillus anthracis infection	1G40	Phase 1	[2]
IQ-DAA	DMHP71R	Bacillus anthracis infection	1G40	Phase 1	[3]
Valortim	DMYAIUB	Bacterial infection	1A00-1C4Z	Phase 1	[4]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Anthrax vaccine	DM9GSWY	Bacillus anthracis infection	1G40	Discontinued in Phase 1	[5]

References

• [1] Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550). J Immunol. 2011 Apr 1;186(7):4234-43.
• [2] Efficacy and Safety of AVP-21D9, an Anthrax Monoclonal Antibody, in Animal Models and Humans. Antimicrob Agents Chemother. 2014 July; 58(7): 3618-3625.
• [3] Anti-toxin antibodies in prophylaxis and treatment of inhalation anthrax.Future Microbiol.2009 Feb;4(1):35-43.
• [4] Phase I Study Evaluating the Safety and Pharmacokinetics of MDX-1303, a Fully Human Monoclonal Antibody against Bacillus anthracis Protective Antigen, in Healthy Volunteers. Clin Vaccine Immunol. 2011 December; 18(12): 2136-2142.
• [5] Annual Reports in Medicinal Chemistry. Annette M. Doherty. 2005. Page(214).