General Information of DTT (ID: TT7WVHI)

DTT Name Soluble epoxide hydrolase (EPHX2) DTT Info
Gene Name EPHX2

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
2 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
AR9281 DMJHA6Q Hypertension BA00-BA04 Phase 2 [1]
GSK2256294 DM7FN12 Chronic obstructive pulmonary disease CA22 Phase 1 [2]
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104 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
1,3-DIPHENYLUREA DMI4H05 Discovery agent N.A. Investigative [3]
1-(1-Adamantyl)-3-(1-propionylpiperidin-4-yl)urea DM7G2AB Discovery agent N.A. Investigative [4]
1-(1-Propionylpiperidin-4-yl)-3-m-tolylurea DMAZR9C Discovery agent N.A. Investigative [4]
1-(1-Propionylpiperidin-4-yl)-3-o-tolylurea DMUH59X Discovery agent N.A. Investigative [4]
1-(1-Propionylpiperidin-4-yl)-3-p-tolylurea DMWUBI4 Discovery agent N.A. Investigative [4]
1-(3-(3-morpholinopropoxy)phenyl)-3-phenylurea DM3EBFS Discovery agent N.A. Investigative [5]
1-(3-Chloro-phenyl)-3-(4-hydroxy-decyl)-urea DMC5PI4 Discovery agent N.A. Investigative [6]
1-(3-Chloro-phenyl)-3-cyclohexyl-urea DM1VLMC Discovery agent N.A. Investigative [6]
1-(4-(3-morpholinopropoxy)phenyl)-3-phenylurea DMYIK9W Discovery agent N.A. Investigative [5]
1-adamantan-1-yl-3-((R)-1-phenyl-ethyl)-urea DMRJSG7 Discovery agent N.A. Investigative [7]
1-adamantan-1-yl-3-(1-benzyl-piperidin-4-yl)-urea DMNXU1O Discovery agent N.A. Investigative [8]
1-adamantan-1-yl-3-(1-butyl-piperidin-4-yl)-urea DMAJC42 Discovery agent N.A. Investigative [8]
1-adamantan-1-yl-3-(1-ethyl-piperidin-4-yl)-urea DMY1Z2X Discovery agent N.A. Investigative [8]
1-adamantan-1-yl-3-(1-propyl-piperidin-4-yl)-urea DM2K7TX Discovery agent N.A. Investigative [8]
1-adamantan-1-yl-3-(2-heptyloxyethyl)urea DMRIYX9 Discovery agent N.A. Investigative [9]
1-Adamantan-1-yl-3-(2-hydroxy-phenyl)-urea DMJ8ZS6 Discovery agent N.A. Investigative [10]
1-adamantan-1-yl-3-(2-hydroxyethyl)urea DMDO9YM Discovery agent N.A. Investigative [9]
1-Adamantan-1-yl-3-(2-methoxy-phenyl)-urea DMRBVFO Discovery agent N.A. Investigative [10]
1-adamantan-1-yl-3-(3-hexyloxypropyl)urea DMGEXOZ Discovery agent N.A. Investigative [9]
1-Adamantan-1-yl-3-(3-hydroxy-phenyl)-urea DM8SEJP Discovery agent N.A. Investigative [10]
1-adamantan-1-yl-3-(3-hydroxypropyl)urea DMZX72E Discovery agent N.A. Investigative [9]
1-Adamantan-1-yl-3-(3-methoxy-phenyl)-urea DMHAS3G Discovery agent N.A. Investigative [10]
1-Adamantan-1-yl-3-(4-hydroxy-decyl)-urea DMHKG89 Discovery agent N.A. Investigative [6]
1-Adamantan-1-yl-3-(4-hydroxy-phenyl)-urea DMUPAR1 Discovery agent N.A. Investigative [10]
1-adamantan-1-yl-3-(4-hydroxybutyl)urea DM53G1V Discovery agent N.A. Investigative [9]
1-Adamantan-1-yl-3-(4-methoxy-phenyl)-urea DMMBYOD Discovery agent N.A. Investigative [10]
1-adamantan-1-yl-3-(4-pentyloxybutyl)urea DM3RE2D Discovery agent N.A. Investigative [9]
1-adamantan-1-yl-3-(4-pentyloxycylclohexyl)urea DMUZ3OS Discovery agent N.A. Investigative [9]
1-adamantan-1-yl-3-(5-butoxypentyl)urea DMEDQVX Discovery agent N.A. Investigative [9]
1-adamantan-1-yl-3-(5-hydroxypentyl)urea DMV6824 Discovery agent N.A. Investigative [9]
1-adamantan-1-yl-3-(6-hydroxyhexyl)urea DMOX5MC Discovery agent N.A. Investigative [9]
1-adamantan-1-yl-3-(6-propyloxyhexyl)urea DMO1L3I Discovery agent N.A. Investigative [9]
1-Adamantan-1-yl-3-decyl-urea DMLD2G3 Discovery agent N.A. Investigative [6]
1-Adamantan-1-yl-3-phenyl-urea DMCFKX0 Discovery agent N.A. Investigative [10]
1-adamantan-1-yl-3-piperidin-4-yl-urea DMTNPBH Discovery agent N.A. Investigative [8]
1-adamantan-1-yl-3-piperidin-4-ylmethyl-urea DMGPIL0 Discovery agent N.A. Investigative [8]
1-adamantan-1-yl-3-[4-(4-fluorophenoxy)butyl]urea DMXRHKQ Discovery agent N.A. Investigative [1]
1-Cycloheptyl-3-(1-propionylpiperidin-4-yl)urea DMA2607 Discovery agent N.A. Investigative [4]
1-Cyclohexyl-3-(1-propionylpiperidin-4-yl)urea DMAZYCD Discovery agent N.A. Investigative [4]
1-Cyclohexyl-3-(4-methoxy-phenyl)-urea DMESUD7 Discovery agent N.A. Investigative [6]
1-Cyclohexyl-3-phenethyl-urea DMH9O6V Discovery agent N.A. Investigative [6]
1-Cyclohexyl-3-phenyl-urea DM9K8HA Discovery agent N.A. Investigative [6]
1-Octyl-3-(1-propionylpiperidin-4-yl)urea DM9OJ7T Discovery agent N.A. Investigative [4]
1-Phenyl-3-(1-propionylpiperidin-4-yl)urea DMCHOFK Discovery agent N.A. Investigative [4]
12-(3-Adamantan-1-yl-ureido)-dodeca noic acid DM84YCI Discovery agent N.A. Investigative [11]
12-(3-n-Hexylureido)dodec-8(Z)-enoic acid DM0F3SR Discovery agent N.A. Investigative [12]
12-(3-n-Pentylureidooxy)dodec-8(Z)-enoic acid DMAFNXZ Discovery agent N.A. Investigative [12]
13-(3-n-Pentylthioureido)tridec-8(Z)-enoic Acid DMIY9DB Discovery agent N.A. Investigative [12]
13-(3-n-Pentylureido)tridec-5(Z)-enoic acid DM0NRJG Discovery agent N.A. Investigative [12]
13-(3-n-Pentylureido)tridec-8(E)-enoic acid DM17DY6 Discovery agent N.A. Investigative [12]
13-(3-n-Pentylureido)tridec-8-ynoic acid DM9VDOG Discovery agent N.A. Investigative [12]
13-(3-Pentyluredo)tridec-8(Z)-enoic acid DM3I6PS Discovery agent N.A. Investigative [12]
13-(5-n-Pentylfuran-2-yl)tridec-8(Z)-enoic acid DM8HRTC Discovery agent N.A. Investigative [12]
13-(N-Isopropylheptanamido)tridec-8(Z)-enoic acid DMXK6D2 Discovery agent N.A. Investigative [12]
13-(N-Methyl-n-heptnamido)tridec-8(Z)-enoic acid DM689TH Discovery agent N.A. Investigative [12]
13-(n-Pentylcarbamoyloxy)tridec-8(Z)-enoic acid DMSF3C8 Discovery agent N.A. Investigative [12]
13-n-Heptanamidotridec-5-ynoic acid DMRVQCB Discovery agent N.A. Investigative [12]
13-n-Heptanamidotridec-8(Z)-enoic acid DM0LGWJ Discovery agent N.A. Investigative [12]
14-(n-Hexylamino)-14-oxotetradec-8(Z)-enoic acid DM5NFB6 Discovery agent N.A. Investigative [12]
16-(3-Ethylureido)hexadec-11(Z)-enoic acid DMCHMNF Discovery agent N.A. Investigative [12]
2-Adamantan-1-yl-N-decyl-acetamide DMJAUH0 Discovery agent N.A. Investigative [6]
2-Cyclohexyl-N-(4-methoxy-phenyl)-acetamide DMF6PMU Discovery agent N.A. Investigative [6]
2-Cyclohexyl-N-phenethyl-acetamide DM89CLH Discovery agent N.A. Investigative [6]
2-Cyclohexyl-N-phenyl-acetamide DMBJUP5 Discovery agent N.A. Investigative [6]
3-(3-Adamantan-1-yl-ureido)-benzoic acid DMT0M94 Discovery agent N.A. Investigative [10]
4,4-Diphenyl-N-(pyridin-3-yl)-butyramide DMM0H9Y Discovery agent N.A. Investigative [13]
4-(3-Adamantan-1-yl-ureido)-benzoic acid DMKUAEY Discovery agent N.A. Investigative [10]
4-(3-cyclohexylureido)butanoic acid DMXFLMK Discovery agent N.A. Investigative [3]
6-amino-N-(2,4-dichlorobenzyl)nicotinamide DMEHG2F Discovery agent N.A. Investigative [14]
6-amino-N-(3,3-diphenylpropyl)nicotinamide DMYI5GU Discovery agent N.A. Investigative [14]
6-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEXANOIC ACID DM1G7P9 Discovery agent N.A. Investigative [3]
9-(3-n-Pentylureido)non-4(Z)-enoic acid DMUIRS1 Discovery agent N.A. Investigative [12]
9-(3-n-Pentylureido)non-4-ynoic acid DMJYMFE Discovery agent N.A. Investigative [12]
Cis-1-adamantan-1-yl-3-(4-hydroxycyclohexyl)urea DMP3F0D Discovery agent N.A. Investigative [1]
Cis-1-adamantan-1-yl-3-(4-methoxycyclohexyl)urea DM8NX3Q Discovery agent N.A. Investigative [1]
Dodecanoic acid adamantan-1-ylamide DM6TIQX Discovery agent N.A. Investigative [6]
EXRD-4605 DMY96KO Hypertension BA00-BA04 Investigative [15]
Methyl 14-(3-n-butylureido)tetradec-8(Z)-enoate DMV1AL5 Discovery agent N.A. Investigative [12]
Methyl 4-(3-cyclohexylureido)butanoate DM9S210 Discovery agent N.A. Investigative [16]
Methyl 6-(3-cyclohexylureido)hexanoate DM9BPQ1 Discovery agent N.A. Investigative [16]
N,N'-dicyclohexyl-urea DMLVMJH Discovery agent N.A. Investigative [1]
N-(3,3-Diphenyl-propyl)-2-pyridine-3-ylacetamide DM4PTR3 Discovery agent N.A. Investigative [13]
N-(3,3-Diphenyl-propyl)-isonicotinamide DMOXR4K Discovery agent N.A. Investigative [13]
N-(3,3-diphenyl-propyl)-nicotinamide DMDYZ9K Discovery agent N.A. Investigative [13]
N-(3-Chloro-phenyl)-2-cyclohexyl-acetamide DME6IKT Discovery agent N.A. Investigative [6]
N-(3-Phenyl-propyl)-nicotinamide DMA7X62 Discovery agent N.A. Investigative [13]
N-(4,4-Diphenyl-butyl)-nicotinamide DM086VJ Discovery agent N.A. Investigative [13]
N-(biphenyl-3-yl)benzo[d]isoxazol-3-amine DM2ZQBS Discovery agent N.A. Investigative [17]
N-(biphenyl-4-yl)benzo[d]isoxazol-3-amine DML10NT Discovery agent N.A. Investigative [17]
N-(naphthalen-1-yl)benzo[d]isoxazol-3-amine DM2CBNG Discovery agent N.A. Investigative [17]
N-(naphthalen-2-yl)benzo[d]isoxazol-3-amine DM2NHVX Discovery agent N.A. Investigative [17]
N-adamantyl-N'-cyclohexylurea DMZ43N1 Discovery agent N.A. Investigative [1]
N-benzyl-6-(3,3,3-trifluoropropoxy)nicotinamide DM7NHRV Discovery agent N.A. Investigative [14]
N-Cyclohexyl-2-(4-methoxy-phenyl)-acetamide DM8HS0B Discovery agent N.A. Investigative [6]
N-Cyclohexyl-2-phenyl-acetamide DM15MQT Discovery agent N.A. Investigative [6]
N-Cyclohexyl-4-phenyl-butyramide DM2COR5 Discovery agent N.A. Investigative [6]
N-Cyclohexyl-N'-(4-Iodophenyl)Urea DMPSYRW Discovery agent N.A. Investigative [18]
N-Cyclohexyl-N'-(Propyl)Phenyl Urea DMYF243 Discovery agent N.A. Investigative [3]
N-Cyclohexyl-N'-Decylurea DM17G82 Discovery agent N.A. Investigative [3]
N-[(CYCLOHEXYLAMINO)CARBONYL]GLYCINE DMHNR36 Discovery agent N.A. Investigative [3]
N-[3,3-Bis-(4-fluorophenyl)-propyl]-benzamide DMKPYEU Discovery agent N.A. Investigative [13]
N-[3,3-Bis-(4-fluorophenyl)-propyl]-nicotinamide DMIP8AK Discovery agent N.A. Investigative [13]
Trans,trans-1,3-bis-(4-hydroxycyclohexyl)urea DMHD1XM Discovery agent N.A. Investigative [1]
[4-(3-Adamantan-1-yl-ureido)-phenyl]-acetic acid DMNCAE9 Discovery agent N.A. Investigative [10]
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⏷ Show the Full List of 104 Investigative Drug(s)
Molecule Interaction Atlas

References

1 Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem. 2007 Aug 9;50(16):3825-40.
2 In vitro and in vivo characterization of a novel soluble epoxide hydrolase inhibitor. Prostaglandins Other Lipid Mediat. 2013 Jul-Aug;104-105:25-31.
3 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
4 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, a... J Med Chem. 2010 Oct 14;53(19):7067-75.
5 Unsymmetrical non-adamantyl N,N'-diaryl urea and amide inhibitors of soluble expoxide hydrolase. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4259-63.
6 Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. J Med Chem. 2005 May 19;48(10):3621-9.
7 Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5773-7.
8 Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5212-6.
9 1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic prope... J Med Chem. 2007 Oct 18;50(21):5217-26.
10 Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1784-9.
11 Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement. J Med Chem. 2009 Aug 27;52(16):5009-12.
12 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxi... J Med Chem. 2009 Aug 27;52(16):5069-75.
13 Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase. J Med Chem. 2009 Oct 8;52(19):5880-95.
14 Design and synthesis of substituted nicotinamides as inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5864-8.
15 Soluble epoxide hydrolase inhibition does not prevent cardiac remodeling and dysfunction after aortic constriction in rats and mice. J Cardiovasc Pharmacol. 2013 Apr;61(4):291-301.
16 Peptidyl-urea based inhibitors of soluble epoxide hydrolases. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5439-44.
17 A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5716-21.
18 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.