Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTAS2UO)

• DTT Name: Bacterial Urease (Bact ureC) DTT Info
• Gene Name: Bact ureC

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetohydroxamic Acid	DMYX7NI	Urinary tract infection	GC08	Approved	[1]

5 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1-cyclohexyl-1-isopropyl-3,3-dimethylselenourea	DMS10LE	Discovery agent	N.A.	Investigative	[2]
3-(4-bromobenzyl)-1,1-dimethylselenourea	DMAKMIJ	Discovery agent	N.A.	Investigative	[2]
3-(4-bromophenyl)-1,1-dimethylthiourea	DMXMZRE	Discovery agent	N.A.	Investigative	[2]
3-dodecyl-1,1-dimethylthiourea	DMO5EBI	Discovery agent	N.A.	Investigative	[2]
N-glycylglycinehydroxamic acid	DMPEZHC	Discovery agent	N.A.	Investigative	[3]

References

• [1] Enzymatic, immunological and phylogenetic characterization of Brucella suis urease. BMC Microbiol. 2008 Jul 19;8:121.
• [2] Facile one-pot synthesis of thio and selenourea derivatives: a new class of potent urease inhibitors. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6387-91.
• [3] Design, synthesis, and evaluation of novel organophosphorus inhibitors of bacterial ureases. J Med Chem. 2008 Sep 25;51(18):5736-44.