Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTDM4ZU)

• DTT Name: Factor XI messenger RNA (F11 mRNA) DTT Info
• Gene Name: F11

Molecule-Related Drug & Molecule List

4 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BMS-986177	DM4QHZS	Cerebral ischemia	8B11	Phase 2	[1]
IONIS-416858	DM5F0QY	Thrombosis	DB61-GB90	Phase 2	[2]
ISIS-FXI	DMHETPI	Coagulation defect	3B10.0	Phase 2	[3]
alpha-ketothiazole analogue 36	DMN2I3P	Alzheimer disease	8A20	Clinical trial	[4]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
FXI-AS1	DMAZ1NW	Thrombosis	DB61-GB90	Investigative	[5]

References

• [1] Discovery methods of coagulation-inhibiting drugs. Expert Opin Drug Discov. 2017 Dec;12(12):1195-1205.
• [2] Clinical pipeline report, company report or official report of Ionis Pharmaceuticals.
• [3] Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011).
• [4] Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg Med Chem. 2008 Feb 15;16(4):1562-95.
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2360).