Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTIHYA4)

• DTT Name: Thrombopoietin receptor (MPL) DTT Info
• UniProt ID: TPOR_HUMAN
• Gene Name: MPL

Molecule-Related Drug & Molecule List

5 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
As-1670542	DMV05SW	Thrombocytopenia	3B64	Approved	[1]
Eltrombopag	DMOGFIX	Thrombocytopenia	3B64	Approved	[2]
Lusutrombopag	DMH6IKO	Thrombocytopenia	3B64	Approved	[3]
Revolade/Promacta	DM8LRU2	Idiopathic thrombocytopenic purpura	3B64.10	Approved	[4]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[5]

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LGD-4665	DM9T8A2	Immune thrombocytopenic purpura	3B64.13	Phase 2	[2]
BVI-007	DM43GPX	Myocardial infarction	BA41-BA43	Phase 1	[1]
NIP-004	DM0PYEQ	Thrombocytopenia	3B64	Phase 1	[6]

3 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RhTPO	DMCV0BZ	Idiopathic thrombocytopenic purpura	3B64.10	Discontinued in Phase 3	[2]
Totrombopag	DM6SUDC	Thrombocytopenia	3B64	Discontinued in Phase 1	[4]
Promegapoietin	DMS4FG0	Bone marrow transplantation	QB63.6	Terminated	[7]

7 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
HL-034	DMMW0OF	Discovery agent	N.A.	Investigative	[1]
Non-peptide TPO mimics	DMZ2DSK	Thrombocytopenia	3B64	Investigative	[1]
RI-TPO	DMJD3WY	Discovery agent	N.A.	Investigative	[8]
SB-559457	DM0OLYF	Acute myeloid leukaemia	2A60	Investigative	[1]
SE-ET-TP020d	DMCQNT9	Thrombocytopenia	3B64	Investigative	[8]
STS-T4	DM5BATX	Thrombocytopenia	3B64	Investigative	[1]
ThromboMer	DMRVXH7	Thrombocytopenia	3B64	Investigative	[1]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1722).
• [2] Emerging drugs for idiopathic thrombocytopenic purpura in adults. Expert Opin Emerg Drugs. 2008 Jun;13(2):237-54.
• [3] 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
• [4] Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
• [5] 2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.
• [6] A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis. Blood. 2006 Jun 1;107(11):4300-7.
• [7] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [8] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.