General Information of DTT (ID: TTIQSC1)

DTT Name Bacterial Lethal factor (Bact lef) DTT Info
Gene Name Bact lef

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Discontinued Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
1 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
IQ-DAA DMHP71R Bacillus anthracis infection 1G40 Phase 1 [1]
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1 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
GM6001 DM7V9CT Corneal ulcer 9A76 Discontinued in Phase 2 [2]
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12 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
3-(2,5-dimethyl-1H-pyrrol-1-yl)benzoic acid DMUDW1J Discovery agent N.A. Investigative [3]
Bisindolylmaleimide-I DMOQJZC Discovery agent N.A. Investigative [4]
GNF-PF-600 DMWGXBF Discovery agent N.A. Investigative [5]
MMI270 DM38N2K Discovery agent N.A. Investigative [6]
N,N'-Bis(4-Amino-2-Methylquinolin-6-Yl)Urea DMT4USP Discovery agent N.A. Investigative [2]
N-(3,4,5-trihydroxyphenethyl)oleamide DMQ5USA Discovery agent N.A. Investigative [7]
N-(3,4-dihydroxybenzyl)oleamide DM67XSW Discovery agent N.A. Investigative [8]
N-(Sulfanylacetyl)Tyrosylprolylmethioninamide DMWJDYZ Discovery agent N.A. Investigative [2]
N-hydroxy-4-(2-oleamidoethyl)benzamide DMKELRB Discovery agent N.A. Investigative [7]
N-hydroxy-4-(oleamidomethyl)benzamide DMUSHZK Discovery agent N.A. Investigative [8]
N-oleoyl-dopamine DM1AVCZ Discovery agent N.A. Investigative [7]
NSC-622445 DME35CB Discovery agent N.A. Investigative [3]
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⏷ Show the Full List of 12 Investigative Drug(s)
Molecule Interaction Atlas

References

1 Anti-toxin antibodies in prophylaxis and treatment of inhalation anthrax.Future Microbiol.2009 Feb;4(1):35-43.
2 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3 Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening. J Med Chem. 2006 Aug 24;49(17):5232-44.
4 Amiodarone and bepridil inhibit anthrax toxin entry into host cells. Antimicrob Agents Chemother. 2007 Jul;51(7):2403-11.
5 Anthrax lethal factor protease inhibitors: synthesis, SAR, and structure-based 3D QSAR studies. J Med Chem. 2006 Jan 12;49(1):27-30.
6 The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection. Bioorg Med Chem Lett. 2006 Feb 15;16(4):964-8.
7 Inhibitors of anthrax lethal factor. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4575-8.
8 Inhibitors of anthrax lethal factor based upon N-oleoyldopamine. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2467-70.