Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTIY56R)

• DTT Name: Kynurenine 3-hydroxylase (KMO) DTT Info
• Gene Name: KMO

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GSK065	DMO87YS	Pancreatitis	DC31-DC34	Phase 1	[1]

36 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aryl pyrimidine derivative 2	DMU9Y4B	N. A.	N. A.	Patented	[2]
Aryl pyrimidine derivative 3	DMXND26	N. A.	N. A.	Patented	[2]
Aryl pyrimidine derivative 4	DMWSAL5	N. A.	N. A.	Patented	[2]
Aryl pyrimidine derivative 5	DMEP9O8	N. A.	N. A.	Patented	[2]
Aryl pyrimidine derivative 6	DMMF9U6	N. A.	N. A.	Patented	[2]
Aryl pyrimidine derivative 7	DM8FAW3	N. A.	N. A.	Patented	[2]
Aryl pyrimidine derivative 8	DM7OA9E	N. A.	N. A.	Patented	[2]
Aryl pyrimidine derivative 9	DMBEYD1	N. A.	N. A.	Patented	[2]
Benzene sulfonamide derivative 1	DMB9VEH	N. A.	N. A.	Patented	[2]
Benzene sulfonamide derivative 2	DMUZQLR	N. A.	N. A.	Patented	[2]
Benzene sulfonamide derivative 3	DMCQLJY	N. A.	N. A.	Patented	[2]
Benzene sulfonamide derivative 4	DMXCUEG	N. A.	N. A.	Patented	[2]
Benzene sulfonamide derivative 5	DMW4NXV	N. A.	N. A.	Patented	[2]
Benzene sulfonamide derivative 6	DMD4UMP	N. A.	N. A.	Patented	[2]
Benzene sulfonamide derivative 7	DM0TKP2	N. A.	N. A.	Patented	[2]
Cyclopropane 1-carboxylic acid derivative 1	DMNXBPQ	N. A.	N. A.	Patented	[2]
Cyclopropane 1-carboxylic acid derivative 10	DM3M169	N. A.	N. A.	Patented	[2]
Cyclopropane 1-carboxylic acid derivative 2	DMSXB58	N. A.	N. A.	Patented	[2]
Cyclopropane 1-carboxylic acid derivative 3	DM6K59I	N. A.	N. A.	Patented	[2]
Cyclopropane 1-carboxylic acid derivative 4	DM8PVN3	N. A.	N. A.	Patented	[2]
Cyclopropane 1-carboxylic acid derivative 5	DMCSIYG	N. A.	N. A.	Patented	[2]
Cyclopropane 1-carboxylic acid derivative 6	DM0OMBW	N. A.	N. A.	Patented	[2]
Cyclopropane 1-carboxylic acid derivative 7	DM4RTMO	N. A.	N. A.	Patented	[2]
Cyclopropane 1-carboxylic acid derivative 8	DM4P9HL	N. A.	N. A.	Patented	[2]
Cyclopropane 1-carboxylic acid derivative 9	DMLH9AQ	N. A.	N. A.	Patented	[2]
Isoxazoles and isoxazoline derivative 1	DMRML9B	N. A.	N. A.	Patented	[2]
Isoxazoles and isoxazoline derivative 2	DMKCYSD	N. A.	N. A.	Patented	[2]
Isoxazoles and isoxazoline derivative 3	DMULJOS	N. A.	N. A.	Patented	[2]
Isoxazoles and isoxazoline derivative 4	DMW3JZV	N. A.	N. A.	Patented	[2]
Isoxazoles and isoxazoline derivative 5	DMCWFU1	N. A.	N. A.	Patented	[2]
Isoxazoles and isoxazoline derivative 6	DMIKBV5	N. A.	N. A.	Patented	[2]
PMID27172114-Compound-47	DMTIQYD	N. A.	N. A.	Patented	[2]
PMID27172114-Compound-49	DMSXJVY	N. A.	N. A.	Patented	[2]
Pyrimidine benzenesulfonamide derivative 1	DMD6GNO	N. A.	N. A.	Patented	[2]
Pyrimidine benzenesulfonamide derivative 2	DMVQ4NS	N. A.	N. A.	Patented	[2]
Pyrimidine benzenesulfonamide derivative 3	DMJ71Q0	N. A.	N. A.	Patented	[2]

5 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CHDI-340246	DMYGITU	Huntington disease	8A01.10	Preclinical	[3]
GSK180	DMNU3SI	Neurodegenerative disorder	8A20-8A23	Preclinical	[4]
GSK366	DM04UGQ	Pancreatitis	DC31-DC34	Preclinical	[1]
Ro 61-8048	DMWAR1T	Neurodegenerative disorder	8A20-8A23	Preclinical	[5]
UPF-648	DMDVZQ8	Neurodegenerative disorder	8A20-8A23	Preclinical	[6]

References

• [1] Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase. Nat Commun. 2017 Jun 12;8:15827.
• [2] Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32.
• [3] The novel KMO inhibitor CHDI-340246 leads to a restoration of electrophysiological alterations in mouse models of Huntington's disease. Exp Neurol. 2016 Aug;282:99-118.
• [4] Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discov. 2019 May;18(5):379-401.
• [5] Modification of kynurenine pathway via inhibition of kynurenine hydroxylase attenuates surgical brain injury complications in a male rat model. J Neurosci Res. 2020 Jan;98(1):155-167.
• [6] Structural basis of kynurenine 3-monooxygenase inhibition. Nature. 2013 Apr 18;496(7445):382-5.