Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTJGW1Z)

• DTT Name: Phosphodiesterase 2A (PDE2A) DTT Info
• Gene Name: PDE2A

Molecule-Related Drug & Molecule List

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CP-461	DMEYMTX	Inflammatory bowel disease	DD72	Phase 2	[1]
Tofisopam	DMTGNWU	Hyperuricaemia	5C55.Y	Phase 2	[2]
ND7001	DMUBTC6	Mood disorder	6A60-6E23	Phase 1	[3]

54 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1,2,4-triazole [1,5-a]pyrimidin-7-yl derivative 1	DMQF62D	N. A.	N. A.	Patented	[4]
1,2,4-triazole [1,5-a]pyrimidin-7-yl derivative 2	DM8KWQ9	N. A.	N. A.	Patented	[4]
1,2,4-triazole [1,5-a]pyrimidin-7-yl derivative 3	DMR1QP4	N. A.	N. A.	Patented	[4]
1,2,4-triazole [4,3-a]quinoxaline derivative 1	DMD9QW2	N. A.	N. A.	Patented	[4]
1,2,4-triazole [4,3-a]quinoxaline derivative 2	DM3DIW9	N. A.	N. A.	Patented	[4]
1,2,4-triazole [4,3-a]quinoxaline derivative 3	DMKXRYM	N. A.	N. A.	Patented	[4]
1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivative 1	DMWNKQ8	N. A.	N. A.	Patented	[4]
1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivative 2	DMU6ST7	N. A.	N. A.	Patented	[4]
1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivative 3	DM62K40	N. A.	N. A.	Patented	[4]
1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivative 4	DMQSTG9	N. A.	N. A.	Patented	[4]
1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivative 5	DM9E0ZD	N. A.	N. A.	Patented	[4]
1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivative 6	DM826JW	N. A.	N. A.	Patented	[4]
Benzodiazepine derivative 2	DM5ZGNK	N. A.	N. A.	Patented	[4]
Imidazo triazine derivative 1	DMLVY7A	N. A.	N. A.	Patented	[4]
Imidazo triazine derivative 2	DMZFG68	N. A.	N. A.	Patented	[4]
Imidazo triazine derivative 3	DM142HI	N. A.	N. A.	Patented	[4]
Imidazo triazine derivative 4	DMZTS2O	N. A.	N. A.	Patented	[4]
Imidazo triazine derivative 5	DM18P4N	N. A.	N. A.	Patented	[4]
Imidazotriazinone derivative 1	DMX34PU	N. A.	N. A.	Patented	[4]
Imidazo[5,1-c]pyrido[2,3-e][1,2,4]triazine derivative 1	DMQBH81	N. A.	N. A.	Patented	[4]
Imidazo[5,1-c]pyrido[2,3-e][1,2,4]triazine derivative 2	DMS3ROL	N. A.	N. A.	Patented	[4]
Imidazo[5,1-c]pyrido[2,3-e][1,2,4]triazine derivative 3	DMZ61T8	N. A.	N. A.	Patented	[4]
Imidazo[5,1-c]pyrido[2,3-e][1,2,4]triazine derivative 4	DMKR5ZO	N. A.	N. A.	Patented	[4]
Imidazo[5,1-c]pyrido[2,3-e][1,2,4]triazine derivative 5	DM7UAKH	N. A.	N. A.	Patented	[4]
Imidazo[5,1-c]pyrido[2,3-e][1,2,4]triazine derivative 6	DMKRUAN	N. A.	N. A.	Patented	[4]
Imidazo[5,1-c]pyrido[2,3-e][1,2,4]triazine derivative 7	DMINBJM	N. A.	N. A.	Patented	[4]
Imidazo[5,1-c]pyrido[2,3-e][1,2,4]triazine derivative 8	DM42EST	N. A.	N. A.	Patented	[4]
Imidazo[5,1-c][1,2,4]benzotriazine derivative 1	DMUB4QL	N. A.	N. A.	Patented	[4]
Imidazo[5,1-c][1,2,4]benzotriazine derivative 2	DMB8AJP	N. A.	N. A.	Patented	[4]
Imidazo[5,1-c][1,2,4]benzotriazine derivative 3	DMYX684	N. A.	N. A.	Patented	[4]
Imidazo[5,1-c][1,2,4]benzotriazine derivative 4	DMWF4S7	N. A.	N. A.	Patented	[4]
Oxindole derivative 1	DMMSVW5	N. A.	N. A.	Patented	[4]
PMID27321640-Compound-58	DM0NYK3	N. A.	N. A.	Patented	[4]
PMID27321640-Compound-59	DM41B5O	N. A.	N. A.	Patented	[4]
PMID27321640-Compound-74	DMHWV67	N. A.	N. A.	Patented	[4]
PMID27321640-Compound-75	DM2P5J9	N. A.	N. A.	Patented	[4]
PMID27321640-Compound-76	DM40LIN	N. A.	N. A.	Patented	[4]
Purin-6-one derivative 1	DM92SWJ	N. A.	N. A.	Patented	[4]
Pyrazolo[3,4-d]pyrimidine derivative 1	DMT57C4	N. A.	N. A.	Patented	[4]
Pyrazolo[3,4-d]pyrimidine derivative 2	DMO054V	N. A.	N. A.	Patented	[4]
Pyrazolo[3,4-d]pyrimidine derivative 3	DMRKVP9	N. A.	N. A.	Patented	[4]
Pyrazolo[3,4-d]pyrimidine derivative 4	DMGFAS6	N. A.	N. A.	Patented	[4]
Pyrido[1,2,4]triazolo[4,3-a]pyrazine derivative 1	DMHKRVL	N. A.	N. A.	Patented	[4]
Pyrido[1,2,4]triazolo[4,3-a]pyrazine derivative 2	DMUO25Y	N. A.	N. A.	Patented	[4]
Pyrido[1,2,4]triazolo[4,3-a]pyrazine derivative 3	DMAEYNT	N. A.	N. A.	Patented	[4]
Pyrido[2,3-d]pyrimidine-2,4-diamine derivative 1	DMM8CL4	N. A.	N. A.	Patented	[4]
Pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazine derivative 1	DMC8935	N. A.	N. A.	Patented	[4]
Pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazine derivative 2	DM4CSBD	N. A.	N. A.	Patented	[4]
Triazolo-phthalazine derivative 1	DMU9A7V	N. A.	N. A.	Patented	[4]
Triazolo-pyridine derivative 2	DMXPQ24	N. A.	N. A.	Patented	[4]
Triazolo-pyridine derivative 3	DMQL1TV	N. A.	N. A.	Patented	[4]
Triazolo-pyridine derivative 4	DM5ZQKS	N. A.	N. A.	Patented	[4]
Triazolo-pyridine derivative 5	DM1R205	N. A.	N. A.	Patented	[4]
Triazolo-pyridine derivative 6	DMX4WFP	N. A.	N. A.	Patented	[4]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IMAZODAN	DMWTFO3	N. A.	N. A.	Terminated	[5]

8 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(2R,3S)-3-(6-Amino-purin-9-yl)-nonan-2-ol	DM852Z6	Discovery agent	N.A.	Investigative	[6]
2-Morpholin-4-yl-8-phenylethynyl-chromen-4-one	DMNKHOI	Discovery agent	N.A.	Investigative	[7]
BAY-60-7550	DMQZ7JD	Discovery agent	N.A.	Investigative	[6]
Benzyl-(2-pyridin-3-yl-quinazolin-4-yl)-amine	DMYDGCI	Discovery agent	N.A.	Investigative	[8]
Benzyl-(2-pyridin-4-yl-quinazolin-4-yl)-amine	DMESVWC	Discovery agent	N.A.	Investigative	[8]
Cyclic Guanosine Monophosphate	DMOU93V	Discovery agent	N.A.	Investigative	[9]
EHNA	DM014WS	Discovery agent	N.A.	Investigative	[10]
isobutylmethylxanthine	DM46F5X	Discovery agent	N.A.	Investigative	[11]

References

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• [2] The atypical anxiolytic drug, tofisopam, selectively blocks phosphodiesterase isoenzymes and is active in the mouse model of negative symptoms of psychosis. J Neural Transm (Vienna). 2010 Nov;117(11):1319-25.
• [3] Phosphodiesterase 2 inhibitors promote axonal outgrowth in organotypic slice co-cultures. Neurosignals. 2013;21(3-4):197-212.
• [4] Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46.
• [5] Cardiotonic agents. 1. 4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3 (2H)-pyridazinones: novel positive inotropic agents for the treatment of conges... J Med Chem. 1984 Sep;27(9):1099-101.
• [6] The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases. J Med Chem. 2005 May 19;48(10):3449-62.
• [7] PDE2 inhibition by the PI3 kinase inhibitor LY294002 and analogues. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2847-51.
• [8] Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and th... J Med Chem. 1995 Sep 1;38(18):3547-57.
• [9] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [10] Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram. Cell Signal. 1996 Feb;8(2):97-110.
• [11] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.