Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTMNI76)

• DTT Name: Calcium-activated potassium channel (KCN) DTT Info
• Gene Name: KCN

Molecule-Related Drug & Molecule List

2 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Charybdotoxin	DMKN345	Scorpion envenoming syndrome	8D43	Approved	[1]
Chlorzoxazone	DMCYVDT	Acute pain	MG31	Approved	[2]

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ICA-17043	DMRFY7I	Alzheimer disease	8A20	Phase 2	[3]

20 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(2-fluorophenyl)-(4-fluorophenyl)phenylacetamide	DMFV76H	Discovery agent	N.A.	Investigative	[3]
1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole	DMQEJVU	Conjunctival fibrosis	9A61.3	Investigative	[4]
2,2,2-tris-(3-fluorophenyl)-acetamide	DMJXAF7	Discovery agent	N.A.	Investigative	[3]
2,2,2-tris-(4-fluorophenyl)-acetamide	DMCZHEN	Discovery agent	N.A.	Investigative	[3]
2,2-bis-(2-fluorophenyl)-2-phenylacetamide	DMDIX40	Discovery agent	N.A.	Investigative	[3]
2,2-bis-(3-fluorophenyl)-2-phenylacetamide	DM6ICRJ	Discovery agent	N.A.	Investigative	[3]
2-(2,4-difluorophenyl)-2,2-diphenylacetamide	DMSND8U	Discovery agent	N.A.	Investigative	[3]
2-(2-chlorophenyl)-2,2-diphenylethanamide	DM60RWZ	Discovery agent	N.A.	Investigative	[3]
2-(3,4-Difluorophenyl)-2,2-diphenylacetamide	DMJKVZ3	Discovery agent	N.A.	Investigative	[3]
2-fluorophenyl-2,2-diphenylacetamide	DMNPGXA	Discovery agent	N.A.	Investigative	[3]
2-trityl-4,5-dihydrooxazole	DMVJORE	Discovery agent	N.A.	Investigative	[3]
4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one	DMKMH5L	Discovery agent	N.A.	Investigative	[4]
4-fluorophenyl-2,2-diphenylacetamide	DMI03KV	Discovery agent	N.A.	Investigative	[3]
5-tosyl-5H-dibenzo[b,d]azepin-7(6H)-one	DMTB91D	Discovery agent	N.A.	Investigative	[4]
Bis(4-fluorophenyl)-2-fluorophenylacetamide	DMO6HWJ	Discovery agent	N.A.	Investigative	[3]
N,N-dimethyl-2,2,2-triphenylacetamide	DM9XZJN	Discovery agent	N.A.	Investigative	[3]
N-ethyl-2,2,2-triphenylacetamide	DMQ3184	Discovery agent	N.A.	Investigative	[3]
N-methyl-2,2,2-triphenylacetamide	DMQGRMO	Discovery agent	N.A.	Investigative	[3]
Triphenylacetic acid methyl ester	DM2VIDK	Discovery agent	N.A.	Investigative	[3]
TRIPHENYLMETHANAMINE	DM3CQIZ	Discovery agent	N.A.	Investigative	[3]

References

• [1] Reversible inhibition of the platelet procoagulant response through manipulation of the Gardos channel. Blood. 2006 Oct 1;108(7):2223-8.
• [2] Chlorzoxazone inhibits contraction of rat thoracic aorta. Eur J Pharmacol. 2006 Sep 18;545(2-3):161-6.
• [3] Novel inhibitors of the Gardos channel for the treatment of sickle cell disease. J Med Chem. 2008 Feb 28;51(4):976-82.
• [4] Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2299-304.