Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTN451K)

• DTT Name: Aromatic-L-amino-acid decarboxylase (DDC) DTT Info
• Gene Name: DDC

Molecule-Related Drug & Molecule List

2 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbidopa	DMHRG8Q	Parkinson disease	8A00.0	Approved	[1]
Vitamin B6	DMDBZMV	Vitamin B6 deficiency	5B5D	Approved	[2]

9 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benserazide	DMLU8NX	N. A.	N. A.	Phase 3	[1]
Patrome	DM3H2U4	Parkinson disease	8A00.0	Phase 3	[3]
AV-201	DMDL9WU	Parkinson disease	8A00.0	Phase 2	[4]
GT-AADC	DM8N3OQ	Aromatic L-amino acid decarboxylase deficiency	5C59.00	Phase 2	[5]
PTC-AADC	DM9ZHE3	Aromatic L-amino acid decarboxylase deficiency	5C59.00	Phase 2	[6]
VY-AADC	DMPSBTL	Parkinson disease	8A00.0	Phase 2	[7]
OXB-102	DMXF9DM	Parkinson disease	8A00.0	Phase 1/2	[8]
ProSavin	DMJ42E6	Parkinson disease	8A00.0	Phase 1/2	[9]
VY-AADC01	DM0N71R	Parkinson disease	8A00.0	Phase 1	[10]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
3-hydroxybenzylhydrazine	DMNUM4K	Discovery agent	N.A.	Investigative	[11]
Noradrenalone (arterenone)	DMFNB40	Discovery agent	N.A.	Investigative	[12]

References

• [1] Catechol-O-methyltransferase inhibitors in the management of Parkinson's disease. Semin Neurol. 2001;21(1):15-22.
• [2] Functional COMT variant predicts response to high dose pyridoxine in Parkinson's disease. Am J Med Genet B Neuropsychiatr Genet. 2005 Aug 5;137B(1):1-4.
• [3] The aromatic-L-amino acid decarboxylase inhibitor carbidopa is selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells. Clin Cancer Res. 2000 Nov;6(11):4365-72.
• [4] UCSF report
• [5] Clinical pipeline report, company report or official report of PTC Therapeutics.
• [6] ClinicalTrials.gov (NCT04903288) An Open-Label Trial to Address the Safety of the SmartFlow MR-Compatible Ventricular Cannula for Administering Eladocagene Exuparvovec to Pediatric Subjects. U.S.National Institutes of Health.
• [7] Clinical pipeline report, company report or official report of Voyager Therapeutics.
• [8] Clinical pipeline report, company report or official report of Oxford BioMedica.
• [9] Clinical pipeline report, company report or official report of Oxford BioMedica.
• [10] Safety of AADC Gene Therapy for Moderately Advanced Parkinson Disease: Three-Year Outcomes From the PD-1101 Trial. Neurology. 2022 Jan 4;98(1):e40-e50.
• [11] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1271).
• [12] Activation of an adrenergic pro-drug through sequential stereoselective action of tandem target enzymes. Biochem Biophys Res Commun. 1992 Nov 30;189(1):33-9.