General Information of DTT (ID: TTQ3JTF)

DTT Name Muscarinic acetylcholine receptor M4 (CHRM4) DTT Info
Gene Name CHRM4

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Approved Drug(s)
Investigative Drug(s)
4 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
ACECLIDINE DMOLNCZ Glaucoma/ocular hypertension 9C61 Approved [1]
Diphenidol DMHPWOM Nausea MD90 Approved [2]
Methacholine Chloride DMGS4QH Asthma CA23 Approved [3]
Tropicamide DM1D90W Mydriasis LA11.62 Approved [4]
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35 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
1'-Benzyl-3-phenyl-[3,4']bipiperidinyl-2,6-dione DMMNH4K Discovery agent N.A. Investigative [5]
1-Methyl-1-(4-pyrrolidin-1-yl-but-2-ynyl)-urea DM9KCXI Discovery agent N.A. Investigative [6]
2,8-Dimethyl-1-oxa-8-aza-spiro[4.5]decan-3-one DMAKZ43 Discovery agent N.A. Investigative [7]
2-Methyl-6-pyrrolidin-1-yl-hex-4-ynal oxime DM8EV4A Discovery agent N.A. Investigative [8]
3-(3-benzylamino)-piperidin-2-one DMYN6Z9 Discovery agent N.A. Investigative [9]
3-Methyl-7-pyrrolidin-1-yl-hept-5-yn-2-one DME81U3 Discovery agent N.A. Investigative [8]
3-Tetrazol-2-yl-1-aza-bicyclo[2.2.2]octane DMIH6JU Discovery agent N.A. Investigative [10]
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G Discovery agent N.A. Investigative [11]
6-Dimethylamino-2-methyl-hex-4-ynal oxime DML2AC1 Discovery agent N.A. Investigative [8]
7-Dimethylamino-3-methyl-hept-5-yn-2-one DMDY2PQ Discovery agent N.A. Investigative [8]
7-Dimethylamino-hept-5-yn-2-one DMH782V Discovery agent N.A. Investigative [8]
7-Pyrrolidin-1-yl-hept-5-yn-2-one DMQJ26K Discovery agent N.A. Investigative [8]
A-987306 DMU34BK Discovery agent N.A. Investigative [12]
Acetic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester DMVEH40 Discovery agent N.A. Investigative [3]
AF-DX-384 DMNY8H7 Discovery agent N.A. Investigative [13]
Benzoic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester DM6T8YM Discovery agent N.A. Investigative [14]
BRL-55473 DMEMZ6Q Discovery agent N.A. Investigative [15]
CMI-1145 DMYPG01 Discovery agent N.A. Investigative [16]
CMI-936 DMT9YKG Discovery agent N.A. Investigative [16]
Cremastrine DMLJOGK Discovery agent N.A. Investigative [17]
FLUMEZAPINE DMW0HOG Discovery agent N.A. Investigative [18]
FM1-10 DM5782Z Discovery agent N.A. Investigative [19]
FM1-43 DMAP8VY Discovery agent N.A. Investigative [19]
GNF-PF-5618 DMT8VUS Discovery agent N.A. Investigative [20]
ISOCLOZAPINE DM52CPU Discovery agent N.A. Investigative [21]
ISOLOXAPINE DMH1BN4 Discovery agent N.A. Investigative [22]
N-(4-Dimethylamino-but-2-ynyl)-N-methyl-acetamide DMB3E7H Discovery agent N.A. Investigative [8]
N-methoxyquinuclidine-3-carboximidoyl chloride DMMB3PG Discovery agent N.A. Investigative [15]
N-methoxyquinuclidine-3-carboximidoyl fluoride DMF8IA6 Discovery agent N.A. Investigative [15]
PF-3409409 DMEZA0T Attention deficit hyperactivity disorder 6A05.Z Investigative [23]
Propionic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester DMO325J Discovery agent N.A. Investigative [14]
PTAC DMEJ6SK Discovery agent N.A. Investigative [24]
SULFOARECOLINE DM8KYUE Discovery agent N.A. Investigative [25]
VU10007 DM31V7K Discovery agent N.A. Investigative [26]
VU10010 DM2HGCB Discovery agent N.A. Investigative [26]
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⏷ Show the Full List of 35 Investigative Drug(s)
Molecule Interaction Atlas

References

1 Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists. J Med Chem. 1993 Apr 2;36(7):842-7.
2 Diphenidol-related diamines as novel muscarinic M4 receptor antagonists. Bioorg Med Chem Lett. 2008 May 1;18(9):2972-6.
3 6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors. J Med Chem. 1998 Jun 4;41(12):2047-55.
4 The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 rec... Psychopharmacology (Berl). 2007 Oct;194(3):347-59.
5 Synthesis and biological evaluation of [125I]- and [123I]-4-iododexetimide, a potent muscarinic cholinergic receptor antagonist. J Med Chem. 1989 May;32(5):1057-62.
6 Urea and 2-imidazolidone derivatives of the muscarinic agents oxotremorine and N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide. J Med Chem. 1992 Aug 21;35(17):3270-9.
7 Synthesis and modeling studies of a potent conformationally rigid muscarinic agonist: 1-azabicyclo[2.2.1]heptanespirofuranone. J Med Chem. 1998 Oct 22;41(22):4181-5.
8 Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992).
9 Designing active template molecules by combining computational de novo design and human chemist's expertise. J Med Chem. 2007 Apr 19;50(8):1925-32.
10 Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives. J Med Chem. 1992 Apr 3;35(7):1280-90.
11 Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97.
12 cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8.
13 M2/M4 muscarinic receptor binding in the anterior cingulate cortex in schizophrenia and mood disorders. Brain Res Bull. 2005 May 15;65(5):397-403.
14 6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors. J Med Chem. 2000 Jun 29;43(13):2514-22.
15 A novel and selective class of azabicyclic muscarinic agonists incorporating an N-methoxy imidoyl halide or nitrile functionality, Bioorg. Med. Chem. Lett. 2(8):791-796 (1992).
16 Evaluation of muscarinic agonist-induced analgesia in muscarinic acetylcholine receptor knockout mice. Mol Pharmacol. 2002 Nov;62(5):1084-93.
17 Cremastrine, a pyrrolizidine alkaloid from Cremastra appendiculata. J Nat Prod. 2005 Apr;68(4):572-3.
18 Synthesis and pharmacological evaluation of a series of 4-piperazinylpyrazolo[3,4-b]- and -[4,3-b][1,5]benzodiazepines as potential anxiolytics. J Med Chem. 1989 Dec;32(12):2573-82.
19 Design and synthesis of a fluorescent muscarinic antagonist. Bioorg Med Chem Lett. 2008 Jan 15;18(2):825-7.
20 Nocardimicins A, B, C, D, E, and F, siderophores with muscarinic M3 receptor inhibiting activity from Nocardia sp. TP-A0674. J Nat Prod. 2005 Jul;68(7):1061-5.
21 Chloro-substituted, sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents. J Med Chem. 1990 Feb;33(2):809-14.
22 Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain. J Med Chem. 1981 Sep;24(9):1021-6.
23 Design, synthesis and evaluation of N-[(3S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more po... Bioorg Med Chem Lett. 2009 Aug 15;19(16):4579-83.
24 Function of pulmonary neuronal M(2) muscarinic receptors in stable chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001 May;163(6):1320-5.
25 Heterocyclic muscarinic agonists. Synthesis and biological activity of some bicyclic sulfonium arecoline bioisosteres. J Med Chem. 1988 Jul;31(7):1312-6.
26 An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Nat Chem Biol. 2008 Jan;4(1):42-50.