Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTVDSZ0)

• DTT Name: Poly [ADP-ribose] polymerase 1 (PARP1) DTT Info
• Gene Name: PARP1

Molecule-Related Drug & Molecule List

3 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
KU-0058948	DMSA4HZ	Ovarian cancer	2C73	Approved	[1]
Nicotinamide	DMUPE07	Acne vulgaris	ED80	Approved	[2]
Niraparib Tosylate	DMLPSWQ	Fallopian tube cancer	2C74	Approved	[3]

8 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CC-486	DMTNQB0	Acute myeloid leukaemia	2A60	Phase 3	[4]
Nicaraven	DMFBNA3	Cerebrovascular disease	8B2Z	Phase 3	[5]
AG140699	DMA9FKY	Melanoma	2C30	Phase 2	[6]
AZD5305	DMW9R1C	Prostate cancer	2C82.0	Phase 2	[7]
PMID27841036-Compound-37	DM0OVZ2	Ovarian cancer	2C73	Phase 2	[8]
Stenoparib	DMKVBL8	Ovarian cancer	2C73	Phase 2	[9]
AMXI 5001	DMR9H6B	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[10]
NMS-03305293	DM2XIRW	Solid tumour/cancer	2A00-2F9Z	Phase 1	[11]

28 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
3-oxo-2,3-dihydro-1H-indazole-4-carboxamide derivative 1	DMAR2OX	N. A.	N. A.	Patented	[8]
3-oxo-2,3-dihydro-1H-indazole-4-carboxamide derivative 2	DMEVMU9	N. A.	N. A.	Patented	[8]
3-oxo-2,3-dihydro-1H-indazole-4-carboxamide derivative 3	DMRQ74I	N. A.	N. A.	Patented	[8]
3-oxo-2,3-dihydro-1H-indazole-4-carboxamide derivative 4	DM8Q19H	N. A.	N. A.	Patented	[8]
3-oxo-2,3-dihydro-1H-indazole-4-carboxamide derivative 5	DMXJ837	N. A.	N. A.	Patented	[8]
3-phenyl isoquinolin-1(2H) derivative 1	DMB40HC	N. A.	N. A.	Patented	[8]
3-phenyl isoquinolin-1(2H) derivative 2	DMA749P	N. A.	N. A.	Patented	[8]
4-Carboxamido-isoindolinone derivative 1	DMM9I1R	N. A.	N. A.	Patented	[8]
4-Carboxamido-isoindolinone derivative 2	DM3EHSN	N. A.	N. A.	Patented	[8]
4-Carboxamido-isoindolinone derivative 3	DM43YA0	N. A.	N. A.	Patented	[8]
4-Carboxamido-isoindolinone derivative 4	DMTGEFW	N. A.	N. A.	Patented	[8]
4-Carboxamido-isoindolinone derivative 5	DMIYVOC	N. A.	N. A.	Patented	[8]
7-azaindole derivative 8	DMO1920	N. A.	N. A.	Patented	[8]
Benzimidazole carboxamide derivative 1	DMB1L32	N. A.	N. A.	Patented	[8]
Dihydrodiazepinocarbazolone derivative 1	DMC3IN2	N. A.	N. A.	Patented	[8]
Dihydropyrido phthalazinone derivative 1	DMWIYFQ	N. A.	N. A.	Patented	[8]
Dihydropyrido phthalazinone derivative 2	DMR4PQN	N. A.	N. A.	Patented	[8]
Phthalazine derivative 3	DMA1OEF	N. A.	N. A.	Patented	[8]
Phthalazine ketone derivative 1	DMD2R1H	N. A.	N. A.	Patented	[8]
Phthalazine ketone derivative 2	DM07C1I	N. A.	N. A.	Patented	[8]
Phthalazine ketone derivative 3	DMIWY93	N. A.	N. A.	Patented	[8]
PMID27841036-Compound-33	DMGXI95	N. A.	N. A.	Patented	[8]
Quinazolinedione derivative 1	DMSD04W	N. A.	N. A.	Patented	[8]
Quinazolinedione derivative 2	DM3TVI6	N. A.	N. A.	Patented	[8]
Quinazolinedione derivative 3	DMZ5GIH	N. A.	N. A.	Patented	[8]
Tetra-cyclic pyridophthalazinone derivative 1	DMX2EFL	N. A.	N. A.	Patented	[8]
Tetra-hydro-quinoline derivative 1	DMM92KW	N. A.	N. A.	Patented	[8]
Tricyclic indole compound 13	DMS6XT4	N. A.	N. A.	Patented	[8]

2 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CPH-102	DMQGRC8	Solid tumour/cancer	2A00-2F9Z	Preclinical	[12]
PJ34	DMXO6YH	Coronavirus infection	1D92	Preclinical	[13]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NU1025	DMPA8WO	N. A.	N. A.	Terminated	[14]

89 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(E)-N-(4-Phenylthiazol-2-yl) cinnamamide	DM7XIH3	Discovery agent	N.A.	Investigative	[15]
1,2,3,4,4a,5-hexahydrophenanthridin-6(10bH)-one	DM7JMCI	Discovery agent	N.A.	Investigative	[15]
1,7,8,9-tetrahydro-1,5-diaza-trindene-4,6-dione	DMBU796	Discovery agent	N.A.	Investigative	[16]
2,3-dihydro-1H-benzo[de]isoquinolin-1-one	DMB3WI8	Discovery agent	N.A.	Investigative	[17]
2,8-Dimethyl-3H-quinazolin-4-one	DMU2EFH	Discovery agent	N.A.	Investigative	[18]
2-(2-Chlorophenyl)-2H-indazole-7-carboxamide	DMTYDX2	Discovery agent	N.A.	Investigative	[19]
2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide	DMCDGAU	Discovery agent	N.A.	Investigative	[14]
2-(3-Chlorophenyl)-2H-indazole-7-carboxamide	DMYQBSV	Discovery agent	N.A.	Investigative	[19]
2-(3-Piperidin-1-yl-propyl)-3H-quinazolin-4-one	DMZ5H8O	Discovery agent	N.A.	Investigative	[20]
2-(4-Amino-phenyl)-8-hydroxy-3H-quinazolin-4-one	DM7LBEG	Discovery agent	N.A.	Investigative	[18]
2-(4-Amino-phenyl)-8-methyl-3H-quinazolin-4-one	DMJRDAQ	Discovery agent	N.A.	Investigative	[18]
2-(4-Azido-phenyl)-8-methoxy-3H-quinazolin-4-one	DM2JG49	Discovery agent	N.A.	Investigative	[18]
2-(4-Chlorophenyl)-2H-indazole-7-carboxamide	DM6Z9U4	Discovery agent	N.A.	Investigative	[19]
2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide	DM9SGBO	Discovery agent	N.A.	Investigative	[21]
2-(4-Hydroxy-phenyl)-8-methyl-3H-quinazolin-4-one	DMVHQM9	Discovery agent	N.A.	Investigative	[18]
2-(4-Methoxy-phenyl)-8-methyl-3H-quinazolin-4-one	DMS572H	Discovery agent	N.A.	Investigative	[18]
2-(4-methoxyphenyl)quinoline-8-carboxamide	DMBRETS	Discovery agent	N.A.	Investigative	[22]
2-Benzyl-2H-indazole-7-carboxamide	DMPYB93	Discovery agent	N.A.	Investigative	[19]
2-ethylquinoline-8-carboxamide	DMKR47X	Discovery agent	N.A.	Investigative	[22]
2-Methylquinoline-8-carboxamide	DMUN3LV	Discovery agent	N.A.	Investigative	[22]
2-phenyl-2H-benzo[d][1,2,3]triazole-4-carboxamide	DMTSBJL	Discovery agent	N.A.	Investigative	[19]
2-phenyl-2H-indazole-7-carboxamide	DM8HSMU	Discovery agent	N.A.	Investigative	[19]
2-phenylpyrazolo-[1,5-a]pyridine-7-carboxamide	DM64JE8	Discovery agent	N.A.	Investigative	[19]
2-phenylquinoline-8-carboxamide	DMAENRQ	Discovery agent	N.A.	Investigative	[22]
2H-Isoquinolin-1-one	DMHR1UE	Discovery agent	N.A.	Investigative	[18]
3-(4-aminophenyl)quinoxaline-5-carboxamide	DM6XTBI	Discovery agent	N.A.	Investigative	[15]
3-(4-cyanophenyl)quinoxaline-5-carboxamide	DM23JIY	Discovery agent	N.A.	Investigative	[15]
3-(4-methoxyphenyl)quinoxaline-5-carboxamide	DM7WPQC	Discovery agent	N.A.	Investigative	[15]
3-aminobenzamide	DM7P3IZ	Discovery agent	N.A.	Investigative	[13]
3-aminobenzo[c][1,5]naphthyridin-6(5H)-one	DML2UCP	Discovery agent	N.A.	Investigative	[15]
3-Ethenylquinoline-8-carboxamide	DMTKQNU	Discovery agent	N.A.	Investigative	[22]
3-Ethylquinoline-8-carboxamide	DMGPRBE	Discovery agent	N.A.	Investigative	[22]
3-Ethynylquinoline-8-carboxamide	DMS4JGT	Discovery agent	N.A.	Investigative	[22]
3-Hydroxy-benzamide	DMNV1P3	Discovery agent	N.A.	Investigative	[18]
3-Methoxybenzamide	DM245AB	Discovery agent	N.A.	Investigative	[21]
3-Methylquinoline-8-carboxamide	DMQZULR	Discovery agent	N.A.	Investigative	[22]
3-Morpholin-4-ylmethyl-5H-phenanthridin-6-one	DM0YS25	Discovery agent	N.A.	Investigative	[23]
3-Phenylquinoline-8-carboxamide	DM12SKU	Discovery agent	N.A.	Investigative	[22]
3-Prop-1-ynylquinoline-8-carboxamide	DM23I8E	Discovery agent	N.A.	Investigative	[22]
4-(4-Morpholin-4-yl-butyl)-2H-phthalazin-1-one	DMS74F2	Discovery agent	N.A.	Investigative	[23]
4-(5-Morpholin-4-yl-pentyl)-2H-phthalazin-1-one	DMXHIK5	Discovery agent	N.A.	Investigative	[23]
4-amino-1,8-naphthalimide	DMU49H6	Discovery agent	N.A.	Investigative	[14]
4-benzylphthalazin-1(2H)-one	DMA5FEM	Discovery agent	N.A.	Investigative	[15]
4-methylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	DMVMHBL	Discovery agent	N.A.	Investigative	[16]
5-amino-3,4-dihydroisoquinolin-1(2H)-one	DMR853M	Discovery agent	N.A.	Investigative	[17]
5-aminoisoquinolin-1(2H)-one	DMVPSXW	Discovery agent	N.A.	Investigative	[22]
5-Chloro-2-methyl-3H-quinazolin-4-one	DM6YBZR	Discovery agent	N.A.	Investigative	[20]
5-methylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	DMYERNM	Discovery agent	N.A.	Investigative	[16]
8-Amino-6H,11H-indeno[1,2-c]isoquinolin-5-one	DMTRBDP	Discovery agent	N.A.	Investigative	[24]
8-Fluoro-6H,11H-indeno[1,2-c]isoquinolin-5-one	DMKPMFJ	Discovery agent	N.A.	Investigative	[24]
8-Hydroxy-2-(4-nitro-phenyl)-3H-quinazolin-4-one	DMNE52B	Discovery agent	N.A.	Investigative	[18]
8-Hydroxy-2-phenyl-3H-quinazolin-4-one	DMKD2Q4	Discovery agent	N.A.	Investigative	[18]
8-Methoxy-2-(4-nitro-phenyl)-3H-quinazolin-4-one	DMSN0ZE	Discovery agent	N.A.	Investigative	[18]
8-Methoxy-2-methyl-3H-quinazolin-4-one	DMOPN4K	Discovery agent	N.A.	Investigative	[18]
8-Methoxy-2-phenyl-3H-quinazolin-4-one	DM56EW7	Discovery agent	N.A.	Investigative	[18]
8-Methyl-2-(4-nitro-phenyl)-3H-quinazolin-4-one	DM7FSZM	Discovery agent	N.A.	Investigative	[18]
8-Methyl-2-phenyl-3H-quinazolin-4-one	DMEM6Q0	Discovery agent	N.A.	Investigative	[18]
8-Nitro-6H,11H-indeno[1,2-c]isoquinolin-5-one	DM5L40C	Discovery agent	N.A.	Investigative	[24]
9-Amino-6H,11H-indeno[1,2-c]isoquinolin-5-one	DMUL6QR	Discovery agent	N.A.	Investigative	[24]
9-Fluoro-6H,11H-indeno[1,2-c]isoquinolin-5-one	DMGAE9Z	Discovery agent	N.A.	Investigative	[24]
A-620223	DM9SXDI	Solid tumour/cancer	2A00-2F9Z	Investigative	[12]
AG-014376	DMHFYNE	Discovery agent	N.A.	Investigative	[25]
ANG-2684	DMDLVH5	Cerebrovascular ischaemia	8B1Z	Investigative	[12]
ANG-2864	DMQ2TNL	Solid tumour/cancer	2A00-2F9Z	Investigative	[12]
Benzo[c][1,5]naphthyridin-6(5H)-one	DMMYGB9	Discovery agent	N.A.	Investigative	[15]
BPI-704001	DMGQXTR	Solid tumour/cancer	2A00-2F9Z	Investigative	[12]
BZ3	DMN5X17	Discovery agent	N.A.	Investigative	[26]
BZ5	DMRXPFM	Discovery agent	N.A.	Investigative	[26]
BZ6	DMF8UWE	Ataxia-telangiectasia	4A01.31	Investigative	[26]
Carba-Nicotinamide-Adenine-Dinucleotide	DMGP4M3	Discovery agent	N.A.	Investigative	[21]
CEP-6800	DMS16BD	Discovery agent	N.A.	Investigative	[27]
DR2313	DM1AV5R	Stroke	8B20	Investigative	[6]
EB-47	DM4UZ6V	Discovery agent	N.A.	Investigative	[6]
HYDAMTIQ	DMY5RDI	Brain ischaemia	8B1Z	Investigative	[12]
INO-1002	DMZEXY9	Solid tumour/cancer	2A00-2F9Z	Investigative	[12]
KR-33889	DMC4YGT	Myocardial infarction	BA41-BA43	Investigative	[12]
KU-58684	DMVGY6K	Discovery agent	N.A.	Investigative	[15]
ME0328	DMCLT1V	Discovery agent	N.A.	Investigative	[28]
N-(4-Phenylthiazol-2-yl)isonicotinamide	DM2OHVJ	Discovery agent	N.A.	Investigative	[15]
PD-128763	DMV1F7U	Discovery agent	N.A.	Investigative	[21]
Pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	DM1X5JR	Discovery agent	N.A.	Investigative	[16]
Pyrrolo[3,4-e]indole-1,3(2H,6H)-dione	DMM4CU9	Discovery agent	N.A.	Investigative	[16]
Quinoline-8-carboxamide	DMV57OZ	Discovery agent	N.A.	Investigative	[22]
S-070	DMANSCK	Solid tumour/cancer	2A00-2F9Z	Investigative	[12]
S-111	DMRVUCY	Solid tumour/cancer	2A00-2F9Z	Investigative	[12]
Thieno-phenanthridin-6-one	DMFDROW	Brain ischaemia	8B1Z	Investigative	[6]
TI3	DMGXSTB	Discovery agent	N.A.	Investigative	[26]
TI4	DMOXINT	Discovery agent	N.A.	Investigative	[26]
[2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala	DMI9RLZ	Discovery agent	N.A.	Investigative	[26]

References

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