Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTX41N9)

• DTT Name: Tyrosine-protein kinase Kit (KIT) DTT Info
• Gene Name: KIT

Molecule-Related Drug & Molecule List

8 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[1]
Pazopanib HCl	DM6U9CQ	Renal cell carcinoma	2C90	Approved	[2]
Pexidartinib	DMS2J0Z	Tenosynovial giant cell tumour	2F7B	Approved	[3]
Ponatinib	DMYGJQO	Acute lymphoblastic leukaemia	2A85	Approved	[4]
Regorafenib	DMHSY1I	Gastrointestinal stromal tumour	2B5B	Approved	[4]
Ripretinib	DM958QB	Gastrointestinal stromal tumour	2B5B	Approved	[5]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[6]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[7]

8 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Famitinib	DMSFWT7	Solid tumour/cancer	2A00-2F9Z	Phase 2	[8]
MP470	DMELUAK	Solid tumour/cancer	2A00-2F9Z	Phase 2	[9]
XL-820	DMMHX9K	Solid tumour/cancer	2A00-2F9Z	Phase 2	[10]
JSP191	DMVEYKS	Hematopoietic stem cell transplantation	QB63	Phase 1/2	[11]
PLX9486	DM5DZEL	Gastrointestinal stromal tumour	2B5B	Phase 1/2	[12]
AMG-191	DMSHK23	Inflammation	1A00-CA43.1	Phase 1	[13]
CART-117 cells	DMAKZTW	Acute myeloid leukaemia	2A60	Phase 1	[14]
OSI-930	DMF2CZ9	Solid tumour/cancer	2A00-2F9Z	Phase 1	[15]

7 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID25656651-Compound-21a	DMCKAON	N. A.	N. A.	Patented	[16]
PMID25656651-Compound-21b	DMVABXI	N. A.	N. A.	Patented	[16]
Pyridine derivative 18	DMBZMYT	N. A.	N. A.	Patented	[17]
Pyridine derivative 19	DMXYT40	N. A.	N. A.	Patented	[17]
Pyridine derivative 20	DMAOF0W	N. A.	N. A.	Patented	[17]
Pyridine derivative 21	DMF3907	N. A.	N. A.	Patented	[17]
Pyridine derivative 22	DMSIERF	N. A.	N. A.	Patented	[17]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Motesanib	DMZAL8C	Non-small-cell lung cancer	2C25.Y	Discontinued in Phase 3	[18]

1 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CAR-T cells targeting CD117	DM9HG6S	Acute myeloid leukaemia	2A60	Preclinical	[19]

17 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
4-(4-aminophenyl)-1H-indazol-3yl-amine	DMK1IWD	Discovery agent	N.A.	Investigative	[20]
5,11-Dimethyl-6H-pyrido[4,3-b]carbazol-9-ol	DMWSLTB	Discovery agent	N.A.	Investigative	[21]
9-Bromo-5,11-dimethyl-6H-pyrido[4,3-b]carbazole	DMQEO7F	Discovery agent	N.A.	Investigative	[21]
9-Methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole	DMDW267	Discovery agent	N.A.	Investigative	[21]
APCK-110	DMNQ9M1	Solid tumour/cancer	2A00-2F9Z	Investigative	[22]
AST-487	DME76KU	Discovery agent	N.A.	Investigative	[23]
Bis-(5-hydroxy-1H-indol-2-yl)-methanone	DMTSEXB	Discovery agent	N.A.	Investigative	[24]
CP-673451	DMVBPRO	Discovery agent	N.A.	Investigative	[25]
GTP-14564	DMW23Y9	Discovery agent	N.A.	Investigative	[26]
JNJ-28312141	DMCMH7O	Discovery agent	N.A.	Investigative	[27]
Ki-20227	DM9M3VC	Discovery agent	N.A.	Investigative	[28]
PD-0166326	DMD2CG9	Discovery agent	N.A.	Investigative	[29]
PD-0173956	DM8RW92	Discovery agent	N.A.	Investigative	[29]
Phosphonotyrosine	DM09MY1	Discovery agent	N.A.	Investigative	[30]
PMID22765894C8h	DMH5RFU	Discovery agent	N.A.	Investigative	[31]
PMID23521020C7k	DMPCTED	Discovery agent	N.A.	Investigative	[32]
WBZ-7	DME10AL	Solid tumour/cancer	2A00-2F9Z	Investigative	[22]

References

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• [5] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
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• [17] RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99.
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• [22] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1805).
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• [24] Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2006 Jun 1;49(11):3101-15.
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