Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTZHY6R)

• DTT Name: Glycogen phosphorylase muscle form (GP) DTT Info
• Gene Name: PYGM

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
URSOLIC ACID	DM4SOAW	Metabolic syndrome x	5C50-5D2Z	Phase 2	[1]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
JTT-651	DMGP42Q	Type-2 diabetes	5A11	Discontinued in Phase 1	[2]

41 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1-D-glucopyranosyl cytosine	DM4NBUH	Discovery agent	N.A.	Investigative	[3]
1-D-glucopyranosyl uracil	DM90ULM	Discovery agent	N.A.	Investigative	[3]
1-Deoxy-1-Methoxycarbamido-Beta-D-Glucopyranose	DMOEQDP	Discovery agent	N.A.	Investigative	[4]
1-N-Acetyl-Beta-D-Glucosamine	DMF87Z5	Discovery agent	N.A.	Investigative	[4]
2-Deoxy-Glucose-6-Phosphate	DMMPL3D	Discovery agent	N.A.	Investigative	[4]
2-Hydroxyiminoolean-12-en-28-oic acid	DMNXV2I	Discovery agent	N.A.	Investigative	[1]
2-Hydroxyiminours-12-en-28-oic acid	DMDKF03	Discovery agent	N.A.	Investigative	[1]
2-isooleanolic acid	DMOVRX7	Discovery agent	N.A.	Investigative	[1]
2-isoursolic acid	DMEZFKS	Discovery agent	N.A.	Investigative	[1]
2-Oxoolean-12-en-28-oic acid	DMDMK81	Discovery agent	N.A.	Investigative	[1]
23-hydroxybetulinic acid	DM27GH0	Discovery agent	N.A.	Investigative	[5]
2alpha-Hydroxyolean-12-en-28-oic acid	DMHY2RA	Discovery agent	N.A.	Investigative	[1]
2alpha-Hydroxyurs-12-en-28-oic acid	DM1RSCP	Discovery agent	N.A.	Investigative	[1]
2beta,3alpha-dihydroxyolean-12-en-28-oic acid	DMV4OY2	Discovery agent	N.A.	Investigative	[6]
2beta,3alpha-dihydroxyurs-12-en-28-oic acid	DMU4Q8C	Discovery agent	N.A.	Investigative	[6]
3alpha-Hydroxyurs-12-en-28-oic Acid	DMV6OPB	Discovery agent	N.A.	Investigative	[5]
4-{2-[(3-Nitrobenzoyl)Amino]Phenoxy}Phthalic Acid	DMMGHNA	Discovery agent	N.A.	Investigative	[7]
Acurea	DMMQKCV	Discovery agent	N.A.	Investigative	[8]
Alpha-D-Glucopyranosyl-2-Carboxylic Acid Amide	DMD2TPA	Discovery agent	N.A.	Investigative	[4]
Alpha-D-Glucose-1-Phosphate	DMU36HT	Discovery agent	N.A.	Investigative	[4]
Alpha-D-Glucose-6-Phosphate	DMR0EVN	Discovery agent	N.A.	Investigative	[4]
ASIATIC ACID	DMT8Y65	Discovery agent	N.A.	Investigative	[5]
Benzyl 2-hydroxyiminoolean-12-en-28-oate	DMT3JYE	Discovery agent	N.A.	Investigative	[1]
Beta-D-Glucopyranose Spirohydantoin	DMZ2BR9	Discovery agent	N.A.	Investigative	[4]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[4]
BETULIN	DMGQRON	Discovery agent	N.A.	Investigative	[5]
C-(1-Azido-Alpha-D-Glucopyranosyl) Formamide	DMMPXHQ	Discovery agent	N.A.	Investigative	[9]
C-(1-Hydrogyl-Beta-D-Glucopyranosyl) Formamide	DM3VF9M	Discovery agent	N.A.	Investigative	[4]
Ethyl 2beta-hydroxyolean-12-en-28-oate	DMPUCMV	Discovery agent	N.A.	Investigative	[1]
Fluoro-Phosphite Ion	DMIRBYE	Discovery agent	N.A.	Investigative	[4]
Heptulose-2-Phosphate	DMIAQX4	Discovery agent	N.A.	Investigative	[4]
Indirubin-5-sulfonate	DM08VHZ	Discovery agent	N.A.	Investigative	[4]
Inosinic Acid	DMLR86H	Discovery agent	N.A.	Investigative	[4]
L-serine-O-phosphate	DMTJ1NH	Discovery agent	N.A.	Investigative	[4]
N'-Pyridoxyl-Lysine-5'-Monophosphate	DM3ZHBO	Discovery agent	N.A.	Investigative	[4]
N-Acetyl-N'-Beta-D-Glucopyranosyl Urea	DMUNCFQ	Discovery agent	N.A.	Investigative	[9]
N-Benzoyl-N'-Beta-D-Glucopyranosyl Urea	DM7U81L	Discovery agent	N.A.	Investigative	[4]
N-Butyl 2beta-hydroxyolean-12-en-28-oate	DMAQT6S	Discovery agent	N.A.	Investigative	[1]
Nojirimycine Tetrazole	DMYZRTB	Discovery agent	N.A.	Investigative	[7]
OLEANOLIC_ACID	DMWDMJ3	Discovery agent	N.A.	Investigative	[5]
Oleanonic acid	DMYPJC3	Discovery agent	N.A.	Investigative	[5]

References

• [1] Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase. J Nat Prod. 2009 Aug;72(8):1414-8.
• [2] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026877)
• [3] 1-(3-Deoxy-3-fluoro-beta-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modellin... Bioorg Med Chem. 2010 May 15;18(10):3413-25.
• [4] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [5] Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystal... J Med Chem. 2008 Jun 26;51(12):3540-54.
• [6] Practical synthesis of bredemolic acid, a natural inhibitor of glycogen phosphorylase. J Nat Prod. 2008 Nov;71(11):1877-80.
• [7] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [8] Binding of N-acetyl-N '-beta-D-glucopyranosyl urea and N-benzoyl-N '-beta-D-glucopyranosyl urea to glycogen phosphorylase b: kinetic and crystallographic studies. Eur J Biochem. 2002 Mar;269(6):1684-96.
• [9] DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.