Details of Disease

Disease Name

Postencephalitic Parkinson disease

postencephalitic parkinsonism; postencephalitic Parkinsonism

Definition

A disease believed to be caused by a viral illness that triggers degeneration of the nerve cells in the substantia nigra. Overall, this degeneration leads to clinical parkinsonism.

Disease Hierarchy

DIS18PD0: Idiopathic parkinson disease

DISHGY45: Parkinsonian disorder

DIS1TYXP: Postencephalitic Parkinson disease

Disease Identifiers

MONDO ID

MONDO_0001945

MESH ID

D010301

UMLS CUI

C0030568

MedGen ID

10591

Orphanet ID

97349

SNOMED CT ID

19972008

General Information of Disease (ID: DIS1TYXP)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 9 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Amantadine	DMS3YE9	Approved	Small molecular drug	[1]
Benzatropine	DMF7EXL	Approved	NA	[2]
Biperiden	DME78OA	Approved	Small molecular drug	[3]
Bromocriptine	DMVE3TK	Approved	Small molecular drug	[4]
Carbidopa	DMHRG8Q	Approved	Small molecular drug	[5]
Dopamine	DMPGUCF	Approved	Small molecular drug	[6]
Levodopa	DMN3E57	Approved	Small molecular drug	[7]
Procyclidine	DMHFJDT	Approved	Small molecular drug	[8]
Trihexyphenidyl	DMB19L8	Approved	Small molecular drug	[9]
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⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 4 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
BPIFA2	OTLFSDZD	Strong	Biomarker	[10]
PSPN	OT54LLZJ	Strong	Biomarker	[10]
RIDA	OTW4098I	Strong	Biomarker	[10]
STXBP3	OTTTYMAQ	Strong	Biomarker	[10]
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References

1	Amantadine FDA Label
2	A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
3	Biperiden FDA Label
4	Bromocriptine FDA Label
5	Carbidopa FDA Label
6	Dopamine FDA Label
7	Levodopa FDA Label
8	Procyclidine FDA Label
9	Trihexyphenidyl FDA Label
10	Parkinson's syndrome associated with neurofibrillary degeneration and tau pathologic findings.Mov Disord. 2003 Sep;18 Suppl 6:S28-33. doi: 10.1002/mds.10560.