Details of Disease

Disease Name

Meningococcemia

meningococcal septicemia; meningococcemia

Disease Hierarchy

DISB38M8: Meningococcal infection

DIS6N9RZ: Bacteremia

DIS33W79: Meningococcemia

Disease Identifiers

MONDO ID

MONDO_0042972

MESH ID

D008589

UMLS CUI

C0025306

MedGen ID

6300

SNOMED CT ID

4089001

General Information of Disease (ID: DIS33W79)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Benzylpenicillin	DMS9503	Phase 3	Small molecular drug	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 5 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
C3AR1	TTI6B3F	Strong	Biomarker	[2]
C5	TTKANGO	Strong	Biomarker	[3]
C5AR1	TTHXFA1	Strong	Biomarker	[2]
CPB2	TTP18AY	Strong	Biomarker	[4]
PROC	TTZUXYS	Strong	Altered Expression	[5]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
C5AR2	OTP1Q82J	Strong	Biomarker	[2]
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References

1	[An unusual cause of fever: chronic meningococcemia]. Ned Tijdschr Geneeskd. 1996 Apr 6;140(14):785-7.
2	Distinct roles of the anaphylatoxin receptors C3aR, C5aR1 and C5aR2 in experimental meningococcal infections.Virulence. 2019 Dec;10(1):677-694. doi: 10.1080/21505594.2019.1640035.
3	Complement C5a Receptor 1 Exacerbates the Pathophysiology of N.meningitidis Sepsis and Is a Potential Target for Disease Treatment.mBio. 2018 Jan 23;9(1):e01755-17. doi: 10.1128/mBio.01755-17.
4	Thrombin-activatable fibrinolysis inhibitor is associated with severity and outcome of severe meningococcal infection in children.J Thromb Haemost. 2008 Feb;6(2):268-76. doi: 10.1111/j.1538-7836.2008.02841.x. Epub 2007 Nov 15.
5	An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans.PLoS Pathog. 2018 Apr 9;14(4):e1006981. doi: 10.1371/journal.ppat.1006981. eCollection 2018 Apr.