Details of Disease

General Information of Disease (ID: DIS3SFYT)

• Disease Name: Alcohol-induced disorders
• Synonyms: alcohol induced disorders; alcohol-induced disorder
• Definition: Disorders stemming from the misuse and abuse of alcohol.
• Disease Hierarchy:
  DIS3K4KK: Alcohol-related disorders
  DIS3SFYT: Alcohol-induced disorders
• Disease Identifiers:
  MONDO ID: MONDO_0021699
  MESH ID: D020751
  UMLS CUI: C0236970
  MedGen ID: 65935
  SNOMED CT ID: 719848005

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 10 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ESRRG	TT9ZRHB	moderate	Genetic Variation	[1]
FTO	TTFW3BT	moderate	Genetic Variation	[2]
GRK5	TTTCXO0	moderate	Genetic Variation	[3]
KCNJ6	TTTIBVP	moderate	Genetic Variation	[4]
MBNL2	TTH9OLG	moderate	Genetic Variation	[5]
SEMA3A	TTVKD3S	moderate	Genetic Variation	[1]
ALDH2	TTFLN4T	Strong	Biomarker	[6]
AVPR1B	TTL9MHW	Definitive	Biomarker	[7]
GGT1	TTZVT7O	Definitive	Biomarker	[8]
SLC29A1	TTLXAKE	Definitive	Biomarker	[9]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC39A8	DTLPQGT	moderate	Genetic Variation	[2]

This Disease Is Related to 3 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
ADH1B	DEEN9RD	moderate	Genetic Variation	[2]
ADH1C	DEM1HNL	moderate	Genetic Variation	[2]
ADH4	DEOCWU3	moderate	Genetic Variation	[2]

This Disease Is Related to 24 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
AGBL4	OTOX2H61	moderate	Genetic Variation	[10]
ANKS1B	OT26DGM9	moderate	Genetic Variation	[10]
ARL15	OT00YSWZ	moderate	Genetic Variation	[11]
BRAP	OTB7BAFQ	moderate	Genetic Variation	[12]
CCSER1	OTVLD4J3	moderate	Genetic Variation	[3]
CSRNP3	OTOANEHZ	moderate	Genetic Variation	[3]
CTNNA2	OTJ8G92T	moderate	Genetic Variation	[10]
FAM162A	OT882DND	moderate	Genetic Variation	[3]
FSTL5	OT18C29S	moderate	Genetic Variation	[3]
GCKR	OTSIWXGG	moderate	Genetic Variation	[2]
IGSF22	OTQRM8GQ	moderate	Genetic Variation	[3]
IGSF9B	OTNOMYYQ	moderate	Genetic Variation	[1]
KLF12	OTVH4KD4	moderate	Genetic Variation	[1]
LHPP	OT9AGAIJ	moderate	Genetic Variation	[13]
MICB	OTS2DVDW	moderate	Genetic Variation	[2]
MREG	OT0LUIRG	moderate	Genetic Variation	[14]
NCALD	OTJZ8UEL	moderate	Genetic Variation	[1]
NRXN1	OTJN1JQA	moderate	Genetic Variation	[15]
PECR	OT5MS8EM	moderate	Genetic Variation	[14]
PLGRKT	OT5ITHAW	moderate	Genetic Variation	[3]
PPP1R16B	OTZJFX5C	moderate	Genetic Variation	[16]
RHBDL2	OTJPJ8N6	moderate	Genetic Variation	[1]
SERINC2	OTZ039U0	moderate	Genetic Variation	[17]
STAG3	OTEV0AOD	moderate	Genetic Variation	[1]

References

• [1] Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression.JAMA Psychiatry. 2017 Dec 1;74(12):1234-1241. doi: 10.1001/jamapsychiatry.2017.3275.
• [2] Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.Nat Commun. 2019 Apr 2;10(1):1499. doi: 10.1038/s41467-019-09480-8.
• [3] Ancestry-specific and sex-specific risk alleles identified in a genome-wide gene-by-alcohol dependence interaction study of risky sexual behaviors.Am J Med Genet B Neuropsychiatr Genet. 2017 Dec;174(8):846-853. doi: 10.1002/ajmg.b.32604. Epub 2017 Oct 9.
• [4] Family-based genome-wide association study of frontal oscillations identifies potassium channel gene KCNJ6.Genes Brain Behav. 2012 Aug;11(6):712-9. doi: 10.1111/j.1601-183X.2012.00803.x. Epub 2012 May 31.
• [5] A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications.Biol Psychiatry. 2011 Sep 15;70(6):513-8. doi: 10.1016/j.biopsych.2011.02.028. Epub 2011 May 6.
• [6] Ethanol and acetaldehyde differentially alter extracellular dopamine and serotonin in Aldh2-knockout mouse dorsal striatum: A reverse microdialysis study.Neurotoxicology. 2016 Jan;52:204-9. doi: 10.1016/j.neuro.2015.12.011. Epub 2015 Dec 19.
• [7] Evidence that vasopressin V1b receptors mediate the transition to excessive drinking in ethanol-dependent rats.Addict Biol. 2012 Jan;17(1):76-85. doi: 10.1111/j.1369-1600.2010.00291.x. Epub 2011 Feb 11.
• [8] Significance of serum gamma glutamyl transpeptidase as a marker of alcoholism.Pharmacol Biochem Behav. 1980;13 Suppl 1:95-9. doi: 10.1016/s0091-3057(80)80015-3.
• [9] The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference.Nat Neurosci. 2004 Aug;7(8):855-61. doi: 10.1038/nn1288. Epub 2004 Jul 18.
• [10] Identification of novel risk loci with shared effects on alcoholism, heroin, and methamphetamine dependence.Mol Psychiatry. 2021 Apr;26(4):1152-1161. doi: 10.1038/s41380-019-0497-y. Epub 2019 Aug 28.
• [11] Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.Drug Alcohol Depend. 2014 Sep 1;142:56-62. doi: 10.1016/j.drugalcdep.2014.05.023. Epub 2014 Jun 11.
• [12] Genome-wide association study of alcohol dependence in male Han Chinese and cross-ethnic polygenic risk score comparison.Transl Psychiatry. 2019 Oct 7;9(1):249. doi: 10.1038/s41398-019-0586-3.
• [13] The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene.Neuropsychopharmacology. 2017 Feb;42(3):598-605. doi: 10.1038/npp.2016.153. Epub 2016 Aug 17.
• [14] Genome-wide association study of alcohol dependence.Arch Gen Psychiatry. 2009 Jul;66(7):773-84. doi: 10.1001/archgenpsychiatry.2009.83.
• [15] A genome-wide association study of behavioral disinhibition.Behav Genet. 2013 Sep;43(5):363-73. doi: 10.1007/s10519-013-9606-x. Epub 2013 Aug 14.
• [16] Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis.Genes (Basel). 2017 Jul 17;8(7):183. doi: 10.3390/genes8070183.
• [17] NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent.Drug Alcohol Depend. 2013 May 1;129(3):254-64. doi: 10.1016/j.drugalcdep.2013.02.006. Epub 2013 Feb 28.