Details of Disease

General Information of Disease (ID: DIS5JC9D)

Disease Name	Cytomegalovirus retinitis
Synonyms	cytomegalovirus retinitis; Retinitis, Cytomegaloviral; Cytomegalovirus retinitis; Cytomegalovirus caused retinitis; Cytomegaloviral Retinitis; CMV retinitis
Disease Class	9B72: Retinal inflammation
Definition	Infection of the retina by cytomegalovirus characterized by retinal necrosis, hemorrhage, vessel sheathing, and retinal edema. Cytomegalovirus retinitis is a major opportunistic infection in aids patients and can cause blindness.
Disease Hierarchy	DISRWZEG: Retinitis DISCEMGC: Cytomegalovirus infection DISEM33Q: Infectious disease DISCQV4J: Endophthalmitis DISOE8QI: Infectious disorder of the nervous system DIS7YY4P: Viral eye infection DIS5JC9D: Cytomegalovirus retinitis
ICD Code	ICD-11 ICD-11: 9B72.00 ICD-9 ICD-9: 78.5 Expand ICD-11 '9B72.00 Expand ICD-9 78.5
Disease Identifiers	MONDO ID MONDO_0000878 MESH ID D017726 UMLS CUI C0206178 MedGen ID 61532 SNOMED CT ID 22455005

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 4 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Cidofovir	DMA13GD	Approved	Small molecular drug	[1]
Fomivirsen sodium	DMBEP7G	Approved	Small molecular drug	[2]
Foscavir	DM9KJLZ	Approved	Small molecular drug	[3]
Ganciclovir	DM1MBYQ	Approved	Small molecular drug	[4]
------------------------------------------------------------------------------------

This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
GEM-132	DMJ22ON	Terminated	Small molecular drug	[5]
------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
IFNL3	TTRF4Q2	Strong	Biomarker	[6]
SOCS1	TT8COJM	Strong	Biomarker	[7]
------------------------------------------------------------------------------------

This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
DOCK8	OTNQLL21	Limited	Genetic Variation	[8]
CISH	OT8T5NYL	Strong	Biomarker	[9]
------------------------------------------------------------------------------------

References

1	Cidofovir FDA Label
2	Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
3	FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 020068.
4	Ganciclovir FDA Label
5	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006986)
6	Host Genetics of Cytomegalovirus Pathogenesis.Front Genet. 2019 Jul 23;10:616. doi: 10.3389/fgene.2019.00616. eCollection 2019.
7	Suppressor of Cytokine Signaling 1 (SOCS1) and SOCS3 Are Stimulated within the Eye during Experimental Murine Cytomegalovirus Retinitis in Mice with Retrovirus-Induced Immunosuppression.J Virol. 2018 Aug 29;92(18):e00526-18. doi: 10.1128/JVI.00526-18. Print 2018 Sep 15.
8	Clinical, immunological and genetic features in Taiwanese patients with the phenotype of hyper-immunoglobulin E recurrent infection syndromes (HIES).Immunobiology. 2011 Aug;216(8):909-17. doi: 10.1016/j.imbio.2011.01.008. Epub 2011 Jan 18.
9	SOCS and Herpesviruses, With Emphasis on Cytomegalovirus Retinitis.Front Immunol. 2019 Apr 11;10:732. doi: 10.3389/fimmu.2019.00732. eCollection 2019.