Details of Disease

General Information of Disease (ID: DIS788JD)

Disease Name Hereditary hyperbilirubinemia
Synonyms hyperbilirubinemia; hyperbilirubinaemia; bilirubin metabolic disorder; hereditary hyperbilirubinemia
Definition
An inherited disorder affecting the metabolism of bilirubin. It results in increased levels of bilirubin in the blood. Representative examples of this condition include Gilbert syndrome and Crigler-Najjar syndrome.
Disease Hierarchy
DISFGCQF: Inborn disorder of bilirubin metabolism
DISY9R2N: Hyperbilirubinemia
DIS788JD: Hereditary hyperbilirubinemia
Disease Identifiers
MONDO ID
MONDO_0002408
MESH ID
D006933
UMLS CUI
C0020435
MedGen ID
6963

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 5 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ABCC2 TTFLHJV Limited Biomarker [1]
ABCC3 TTVLG21 Limited Biomarker [2]
F7 TTF0EGX Limited Biomarker [3]
HMBS TTT0HW3 Limited Biomarker [4]
HMGB1 TTWQYB7 Limited Biomarker [5]
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This Disease Is Related to 1 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
ALAS2 DE437BY Limited Biomarker [6]
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This Disease Is Related to 1 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
CALB1 OTM7IXDG Limited Biomarker [7]
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References

1 Function of multidrug resistance-associated protein 2 in acute hepatic failure rats.Eur J Pharmacol. 2006 Sep 28;546(1-3):152-60. doi: 10.1016/j.ejphar.2006.06.079. Epub 2006 Jul 5.
2 Tienilic acid enhances hyperbilirubinemia in Eisai hyperbilirubinuria rats through hepatic multidrug resistance-associated protein 3 and heme oxygenase-1 induction.Toxicol Sci. 2006 Jun;91(2):651-9. doi: 10.1093/toxsci/kfj162. Epub 2006 Mar 16.
3 Expression of MRP2 and MRP3 during liver regeneration after 90% partial hepatectomy in rats.Transplantation. 2004 Jan 15;77(1):22-7. doi: 10.1097/01.TP.0000089234.93366.6D.
4 Inhibition of the biosynthesis of uroporphyrinogen and heme in rat liver during obstructive jaundice produced by bile duct ligation.Arch Biochem Biophys. 1986 Apr;246(1):143-8. doi: 10.1016/0003-9861(86)90457-1.
5 Glucocorticoid modulates high-mobility group box 1 expression and Toll-like receptor activation in obstructive jaundice.J Surg Res. 2011 Sep;170(1):e47-55. doi: 10.1016/j.jss.2011.05.033. Epub 2011 Jun 15.
6 Nature of heme metabolizing enzymes in a mutant rat with hyperbilirubinuria.Res Commun Chem Pathol Pharmacol. 1993 Jun;80(3):329-36.
7 Changes in calcium-binding protein expression in the auditory brainstem nuclei of the jaundiced Gunn rat.Hear Res. 2002 Sep;171(1-2):129-141. doi: 10.1016/s0378-5955(02)00494-x.