Details of Disease

General Information of Disease (ID: DIS9K7PB)

• Disease Name: Mycoses
• Synonyms: mycoses; infections, Fungi; infection, fungal; fungal infection; mycosis; Fungi infectious disease; Fungi infection; Fungi disease or disorder; Fungi caused disease or disorder
• Disease Class: 1F2Z: Mycose
• Definition: An infection caused by a fungus.
• Disease Hierarchy:
  DISEM33Q: Infectious disease
  DIS9K7PB: Mycoses
• ICD Code:
  ICD-11: ICD-11: 1F2Z
  ICD-10: ICD-10: B35-B49
  Expand ICD-11: '1F2Z
  Expand ICD-10: 'B35-B49; 'B48; 'B48.3; 'B48.7; 'B48.8; 'B49
• Disease Identifiers:
  MONDO ID: MONDO_0002041
  MESH ID: D009181
  UMLS CUI: C0026946
  MedGen ID: 6486
  SNOMED CT ID: 3218000

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 12 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Amphotericin B	DMTAJQE	Approved	Small molecular drug	[1]
Benzoic Acid	DMKB9FI	Approved	Small molecular drug	[2]
Caspofungin	DMGQIPT	Approved	Small molecular drug	[3]
Ciclopirox	DMN5T2A	Approved	Small molecular drug	[4]
Clotrimazole	DMMFCIH	Approved	Small molecular drug	[5]
Efinaconazole	DMFA9MV	Approved	Small molecular drug	[6]
Fluconazole	DMOWZ6B	Approved	Small molecular drug	[7]
Itraconazole	DMCR1MV	Approved	Small molecular drug	[8]
Ketoconazole	DMPZI3Q	Approved	Small molecular drug	[9]
Miconazole	DMPMYE8	Approved	Small molecular drug	[10]
Nystatin	DM63QS9	Approved	Small molecular drug	[11]
Sulconazole	DM2SDUF	Approved	Small molecular drug	[12]

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
T-2307	DM9KILX	Phase 1	Small molecular drug	[13]

This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
IPH-41XX	DMI12T5	Investigative	NA	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 10 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ARAF	TT5TURO	Disputed	Biomarker	[14]
CLEC12A	TT70N8V	Disputed	Biomarker	[15]
CLEC6A	TTQ02HK	Disputed	Genetic Variation	[15]
CPA1	TT3LJ6G	Disputed	Biomarker	[16]
ERF	TTGXULC	Disputed	Altered Expression	[17]
GPA33	TT96HUR	Disputed	Biomarker	[18]
CYP51A1	TT67TDP	Strong	Genetic Variation	[19]
CYSLTR1	TTGKOY9	Definitive	Biomarker	[20]
KCNB1	TT5OEKU	Definitive	Biomarker	[21]
RNF34	TTEWDK1	Definitive	Biomarker	[22]

This Disease Is Related to 17 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
DVL2	OTMNYNCM	Disputed	Genetic Variation	[23]
TRNT1	OTD57ILL	Disputed	Genetic Variation	[24]
CDAN1	OTCVZRG6	Definitive	Biomarker	[25]
CDC14A	OTL10OY6	Definitive	Biomarker	[26]
EFEMP2	OT0I2B4J	Definitive	Altered Expression	[27]
HEYL	OTN7BH79	Definitive	Genetic Variation	[28]
HM13	OTGEO1LP	Definitive	Biomarker	[29]
IMMP1L	OTA6LOLR	Definitive	Biomarker	[29]
IMPA1	OTBUVW1Z	Definitive	Biomarker	[29]
MARCO	OT0NW2Q0	Definitive	Biomarker	[30]
NINL	OTWIK6HT	Definitive	Biomarker	[31]
OSBP	OT7R0OQQ	Definitive	Biomarker	[32]
PDSS1	OTXGVHAB	Definitive	Genetic Variation	[33]
PLAC8	OT3SYRUJ	Definitive	Altered Expression	[34]
PRG2	OT0BCPQG	Definitive	Altered Expression	[27]
TNMD	OTHLVA9G	Definitive	Biomarker	[35]
TSPYL2	OTGGW2EF	Definitive	Biomarker	[25]

References

• [1] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [2] Synergistic effect of antioxidant system and osmolyte in hydrogen sulfide and salicylic acid crosstalk-induced heat tolerance in maize (Zea mays L.) seedlings. Plant Signal Behav. 2015;10(9):e1051278.
• [3] Caspofungin FDA Label
• [4] Ciclopirox FDA Label
• [5] Clotrimazole FDA Label
• [6] Efinaconazole FDA Label
• [7] Fluconazole FDA Label
• [8] Itraconazole FDA Label
• [9] Ketoconazole FDA Label
• [10] Miconazole FDA Label
• [11] Nystatin FDA Label
• [12] Sulconazole FDA Label
• [13] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023157)
• [14] In vitro kinetic study of the squalestatin tetraketide synthase dehydratase reveals the stereochemical course of a fungal highly reducing polyketide synthase.Chem Commun (Camb). 2017 Feb 4;53(10):1727-1730. doi: 10.1039/c6cc10172k. Epub 2017 Jan 20.
• [15] LC3-Associated Phagocytosis Is Required for Dendritic Cell Inflammatory Cytokine Response to Gut Commensal Yeast Saccharomyces cerevisiae.Front Immunol. 2017 Oct 25;8:1397. doi: 10.3389/fimmu.2017.01397. eCollection 2017.
• [16] Unravelling the Diversity of the Cyclopiazonic Acid Family of Mycotoxins in Aspergillus flavus by UHPLC Triple-TOF HRMS.Toxins (Basel). 2017 Jan 13;9(1):35. doi: 10.3390/toxins9010035.
• [17] Identification and functional prediction of stress responsive AP2/ERF transcription factors in Brassica napus by genome-wide analysis.Comput Biol Chem. 2017 Dec;71:32-56. doi: 10.1016/j.compbiolchem.2017.09.004. Epub 2017 Sep 14.
• [18] -sarcin and RNase T1 based immunoconjugates: the role of intracellular trafficking in cytotoxic efficiency.FEBS J. 2015 Feb;282(4):673-84. doi: 10.1111/febs.13169. Epub 2014 Dec 26.
• [19] The fungal CYP51s: their functions, structures, related drug resistance, and inhibitors. Front Microbiol. 2019 Apr 24;10:691.
• [20] Cysteinyl leukotrienes as novel host factors facilitating Cryptococcus neoformans penetration into the brain.Cell Microbiol. 2017 Mar;19(3):10.1111/cmi.12661. doi: 10.1111/cmi.12661. Epub 2016 Sep 25.
• [21] Fludioxonil Induces Drk1, a Fungal Group III Hybrid Histidine Kinase, To Dephosphorylate Its Downstream Target, Ypd1.Antimicrob Agents Chemother. 2017 Jan 24;61(2):e01414-16. doi: 10.1128/AAC.01414-16. Print 2017 Feb.
• [22] The Bacterial and Fungal Microbiota of Nelore Steers Is Dynamic Across the Gastrointestinal Tract and Its Fecal-Associated Microbiota Is Correlated to Feed Efficiency.Front Microbiol. 2019 Jun 25;10:1263. doi: 10.3389/fmicb.2019.01263. eCollection 2019.
• [23] The Fungal Metabolite Brefeldin A Inhibits Dvl2-Plk1-Dependent Primary Cilium Disassembly.Mol Cells. 2017 Jun 30;40(6):401-409. doi: 10.14348/molcells.2017.0032. Epub 2017 Jun 14.
• [24] Genotyping bacterial and fungal pathogens using sequence variation in the gene for the CCA-adding enzyme.BMC Microbiol. 2016 Mar 18;16:47. doi: 10.1186/s12866-016-0670-2.
• [25] Cryptococcus neoformans Cda1 and Its Chitin Deacetylase Activity Are Required for Fungal Pathogenesis.mBio. 2018 Nov 20;9(6):e02087-18. doi: 10.1128/mBio.02087-18.
• [26] The Aspergillus flavus Phosphatase CDC14 Regulates Development, Aflatoxin Biosynthesis and Pathogenicity.Front Cell Infect Microbiol. 2018 May 7;8:141. doi: 10.3389/fcimb.2018.00141. eCollection 2018.
• [27] Evolutionary innovation, fungal cell biology, and the lateral gene transfer of a viral KilA-N domain.Curr Opin Genet Dev. 2019 Oct;58-59:103-110. doi: 10.1016/j.gde.2019.08.004. Epub 2019 Oct 7.
• [28] InVivo Confocal Microscopy Cellular Features of Host and Organism in Bacterial, Fungal, and Acanthamoeba Keratitis.Am J Ophthalmol. 2018 Jun;190:24-33. doi: 10.1016/j.ajo.2018.03.010. Epub 2018 Mar 14.
• [29] Molecular and epidemiological analysis of IMP-1 metallo--lactamase-producing Klebsiella pneumoniae in a tertiary care hospital in Japan.J Infect Chemother. 2019 Apr;25(4):240-246. doi: 10.1016/j.jiac.2018.11.012. Epub 2019 Jan 2.
• [30] Scavenger Receptor MARCO Orchestrates Early Defenses and Contributes to Fungal Containment during Cryptococcal Infection.J Immunol. 2017 May 1;198(9):3548-3557. doi: 10.4049/jimmunol.1700057. Epub 2017 Mar 15.
• [31] An Antimicrobial Peptide and Its Neuronal Receptor Regulate Dendrite Degeneration in Aging and Infection.Neuron. 2018 Jan 3;97(1):125-138.e5. doi: 10.1016/j.neuron.2017.12.001.
• [32] The anti-fungal -sitosterol targets the yeast oxysterol-binding protein Osh4.Pest Manag Sci. 2020 Feb;76(2):704-711. doi: 10.1002/ps.5568. Epub 2019 Aug 31.
• [33] Cloning and characterization of decaprenyl diphosphate synthase from three different fungi.Appl Microbiol Biotechnol. 2017 Feb;101(4):1559-1571. doi: 10.1007/s00253-016-7963-0. Epub 2016 Nov 11.
• [34] Yeast expression of mammalian Onzin and fungal FCR1 suggests ancestral functions of PLAC8 proteins in mitochondrial metabolism and DNA repair.Sci Rep. 2019 Apr 29;9(1):6629. doi: 10.1038/s41598-019-43136-3.
• [35] Two New 1,3,4-Oxadiazoles With Effective Antifungal Activity Against Candida albicans.Front Microbiol. 2019 Sep 12;10:2130. doi: 10.3389/fmicb.2019.02130. eCollection 2019.