Details of Disease

General Information of Disease (ID: DISBEPZO)

• Disease Name: Vitamin A deficiency
• Synonyms: deficiency, vitamin A; deficiencies, vitamin A; vitamin A deficiencies; vitamin A deficiency; vitamin A deficiency (disease)
• Definition: Deficiency of vitamin A due to malnutrition, malabsorption, or dietary lack. It is manifested with reduced night vision, night blindness, and xerophthalmia.
• Disease Hierarchy:
  DISD07I9: Vitamin deficiency
  DISBEPZO: Vitamin A deficiency
• Disease Identifiers:
  MONDO ID: MONDO_0007016
  MESH ID: D014802
  UMLS CUI: C0042842
  MedGen ID: 22668
  HPO ID: HP:0004905
  SNOMED CT ID: 72000004

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Vitamin A	DMJ2AH4	Approved	Small molecular drug	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 10 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
DGAT1	TT0GV3R	moderate	Biomarker	[2]
VCAM1	TTHCEF6	moderate	Biomarker	[3]
ABCB11	TTUXCAF	Strong	Altered Expression	[4]
BMP4	TTD3BSX	Strong	Biomarker	[5]
CYP26A1	TTD7Q0R	Strong	Biomarker	[6]
HAMP	TTRV5YJ	Strong	Altered Expression	[7]
PARP1	TTVDSZ0	Strong	Biomarker	[8]
SLC40A1	TT6Y1PG	Strong	Biomarker	[7]
TGM1	TT7A949	Strong	Biomarker	[9]
RBP4	TT0C8BY	Definitive	Genetic Variation	[10]

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
BCO1	DE6BOK3	Strong	Biomarker	[11]

This Disease Is Related to 7 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
BCO2	OTP1L0BZ	Disputed	Biomarker	[12]
IREB2	OT747D24	moderate	Biomarker	[13]
CYBRD1	OTUTVBES	Strong	Biomarker	[7]
LRAT	OTB7CJKY	Strong	Biomarker	[14]
NDUFA2	OTNSTATK	Strong	Biomarker	[15]
RDH11	OTIND43N	Strong	Altered Expression	[16]
STRA8	OT3DKIYB	Strong	Biomarker	[17]

References

• [1] Vitamin A FDA Label
• [2] Alterations in the lipid metabolism of rat aorta: effects of vitamin a deficiency.J Vasc Res. 2006;43(6):602-10. doi: 10.1159/000096247. Epub 2006 Oct 13.
• [3] Implication of vitamin A deficiency on vascular injury related to inflammation and oxidative stress. Effects on the ultrastructure of rat aorta.Eur J Nutr. 2012 Feb;51(1):97-106. doi: 10.1007/s00394-011-0198-z. Epub 2011 Apr 22.
• [4] Low retinol levels differentially modulate bile salt-induced expression of human and mouse hepatic bile salt transporters.Hepatology. 2009 Jan;49(1):151-9. doi: 10.1002/hep.22661.
• [5] Vitamin A regulation of BMP4 expression in the male germ line.Dev Biol. 2005 Oct 1;286(1):78-90. doi: 10.1016/j.ydbio.2005.07.009.
• [6] Vitamin A status affects obesity development and hepatic expression of key genes for fuel metabolism in Zucker fatty rats.Biochem Cell Biol. 2012 Aug;90(4):548-57. doi: 10.1139/o2012-012. Epub 2012 May 3.
• [7] Vitamin A modulates the expression of genes involved in iron bioavailability.Biol Trace Elem Res. 2012 Oct;149(1):64-70. doi: 10.1007/s12011-012-9397-6. Epub 2012 Apr 14.
• [8] Vitamin A depletion causes oxidative stress, mitochondrial dysfunction, and PARP-1-dependent energy deprivation.FASEB J. 2008 Nov;22(11):3878-87. doi: 10.1096/fj.08-112375. Epub 2008 Aug 1.
• [9] Expression of keratinocyte transglutaminase in cornea of vitamin A-deficient rats.Curr Eye Res. 2005 Sep;30(9):731-9. doi: 10.1080/02713680591005940.
• [10] Vitamin A deficiency due to bi-allelic mutation of RBP4: There's more to it than meets the eye.Ophthalmic Genet. 2017 Sep-Oct;38(5):465-466. doi: 10.1080/13816810.2016.1227453. Epub 2016 Nov 28.
• [11] Two carotenoid oxygenases contribute to mammalian provitamin A metabolism.J Biol Chem. 2013 Nov 22;288(47):34081-34096. doi: 10.1074/jbc.M113.501049. Epub 2013 Oct 8.
• [12] -apo-10'-carotenoids support normal embryonic development during vitamin A deficiency.Sci Rep. 2018 Jun 11;8(1):8834. doi: 10.1038/s41598-018-27071-3.
• [13] Vitamin A deficiency aggravates iron deficiency by upregulating the expression of iron regulatory protein-2.Nutrition. 2012 Mar;28(3):281-7. doi: 10.1016/j.nut.2011.08.015. Epub 2011 Dec 9.
• [14] Disruption of the lecithin:retinol acyltransferase gene makes mice more susceptible to vitamin A deficiency.J Biol Chem. 2005 Dec 2;280(48):40226-34. doi: 10.1074/jbc.M509643200. Epub 2005 Sep 20.
• [15] Effect of baseline micronutrient and inflammation status on CD4 recovery post-cART initiation in the multinational PEARLS trial.Clin Nutr. 2019 Jun;38(3):1303-1309. doi: 10.1016/j.clnu.2018.05.014. Epub 2018 May 29.
• [16] Retinyl esters are elevated in progeny of retinol dehydrogenase 11 deficient dams.Chem Biol Interact. 2019 Apr 1;302:117-122. doi: 10.1016/j.cbi.2019.01.041. Epub 2019 Feb 4.
• [17] Stra8 may inhibit apoptosis during mouse spermatogenesis via the AKT signaling pathway.Int J Mol Med. 2018 Nov;42(5):2819-2830. doi: 10.3892/ijmm.2018.3825. Epub 2018 Aug 14.