Details of Disease

General Information of Disease (ID: DISDBPKD)

Disease Name Neurosyphilis
Synonyms neurosyphilis; tertiary neurosyphilis; late neurosyphilis
Definition
Infection of the brain or spinal cord by Treponema pallidum. It occurs many years following the original infection which remained untreated. Signs and symptoms include abnormal gait, blindness, depression, paralysis, seizures and dementia.
Disease Hierarchy
DISXHT8N: Tertiary syphilis
DISDBPKD: Neurosyphilis
Disease Identifiers
MONDO ID
MONDO_0004944
MESH ID
D009494
UMLS CUI
C0027927
MedGen ID
14360
SNOMED CT ID
26039008

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Benzylpenicillin DMS9503 Phase 3 Small molecular drug [1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 2 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
CXCL13 TT0NIZ1 Limited Altered Expression [2]
LAMC2 TTNS7H3 Strong Biomarker [3]
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References

1 Ceftriaxone compared with benzylpenicillin in the treatment of neurosyphilis in France: a retrospective multicentre study. Lancet Infect Dis. 2021 Oct;21(10):1441-1447.
2 Diagnostic value of cerebrospinal fluid CXCL13 for acute Lyme neuroborreliosis. A systematic review and meta-analysis.Clin Microbiol Infect. 2018 Dec;24(12):1234-1240. doi: 10.1016/j.cmi.2018.04.007. Epub 2018 Apr 16.
3 Clinical Manifestations and Cerebrospinal Fluid Status in Ocular Syphilis.Ocul Immunol Inflamm. 2019;27(1):126-130. doi: 10.1080/09273948.2018.1521436. Epub 2018 Sep 19.