Details of Disease

General Information of Disease (ID: DISE6LY9)

• Disease Name: Extragonadal germ cell tumor
• Synonyms: primary extragonadal germ cell tumour; tumour of the extragonadal germ cell; tumour of extragonadal germ cell; tumor of the extragonadal germ cell; extragonadal germ cell tumor; tumor of extragonadal germ cell; neoplasm of the extragonadal germ cell; neoplasm of extragonadal germ cell; extragonadal germ cell neoplasm; primary extragonadal germ cell tumor; extragonadal germ cell neoplasms
• Definition: A germ cell tumor arising in an anatomic site other than the testis or ovary (e.g., central nervous system, lung, mediastinum, and retroperitoneum).
• Disease Hierarchy:
  DIS62070: Germ cell tumor
  DISE6LY9: Extragonadal germ cell tumor
• Disease Identifiers:
  MONDO ID: MONDO_0018201
  UMLS CUI: C0262963
  MedGen ID: 75506
  Orphanet ID: 363579

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 4 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Cisplatin	DMRHGI9	Approved	Small molecular drug	[1]
Ifosfamide	DMCT3I8	Approved	Small molecular drug	[2]
Paclitaxel	DMLB81S	Approved	Small molecular drug	[3]
Vinblastine	DM5TVS3	Approved	Small molecular drug	[4]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
SEM1	OTASLBM1	Strong	Biomarker	[5]

References

• [1] Cisplatin FDA Label
• [2] Ifosfamide FDA Label
• [3] Paclitaxel FDA Label
• [4] Vinblastine FDA Label
• [5] Establishment and characterization of a new human extragonadal germ cell line, SEM-1, and its comparison with TCam-2 and JKT-1.Urology. 2013 Feb;81(2):464.e1-9. doi: 10.1016/j.urology.2012.09.029.