Details of Disease

General Information of Disease (ID: DISN603Q)

• Disease Name: Malignant essential hypertension
• Synonyms: malignant essential hypertension; accelerated essential hypertension
• Disease Class: BA00: Essential hypertension
• Definition: Essential hypertension with rapid progression to severe high blood pressure, papilledema, and renal failure.
• Disease Hierarchy:
  DIS7WI98: Essential hypertension
  DISM4F09: Hypertensive emergency
  DISN603Q: Malignant essential hypertension
• ICD Code:
  ICD-11: ICD-11: BA00
  ICD-10: ICD-10: I10
  Expand ICD-10: C61,N40
• Disease Identifiers:
  MONDO ID: MONDO_0001133
  UMLS CUI: C0024588
  MedGen ID: 9866
  SNOMED CT ID: 78975002

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 30 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Acebutolol	DM0TI4U	Approved	Small molecular drug	[1]
Amlodipine	DMBDAZV	Approved	Small molecular drug	[2]
Atenolol	DMNKG1Z	Approved	Small molecular drug	[3]
Benazepril	DMH1M9B	Approved	Small molecular drug	[2]
Betaxolol	DM6EUL5	Approved	Small molecular drug	[4]
Bisoprolol	DM3UZ95	Approved	Small molecular drug	[5]
Candesartan	DMRK8OT	Approved	Small molecular drug	[6]
Captopril	DM458UM	Approved	Small molecular drug	[7]
Diazoxide	DML1538	Approved	Small molecular drug	[8]
Diltiazem	DMAI7ZV	Approved	Small molecular drug	[9]
Dipyridamole	DMXY30O	Approved	Small molecular drug	[10]
Doxazosin	DM9PLRH	Approved	Small molecular drug	[11]
Enalapril	DMNFUZR	Approved	Small molecular drug	[12]
Enalaprilat	DMFYAM1	Approved	NA	[13]
Fosinopril	DM9NJ52	Approved	Small molecular drug	[14]
Hydralazine	DMU8JGH	Approved	Small molecular drug	[15]
Hydrochlorothiazide	DMUSZHD	Approved	Small molecular drug	[16]
Indapamide	DMGN1PW	Approved	Small molecular drug	[17]
Labetalol	DMK8U72	Approved	Small molecular drug	[18]
Methylphenobarbital	DMDSWAG	Approved	Small molecular drug	[19]
Metoprolol	DMOJ0V6	Approved	Small molecular drug	[20]
Minoxidil	DMA2Z4F	Approved	Small molecular drug	[21]
Nitroprusside	DMLUA2J	Approved	NA	[22]
Oxprenolol	DM51OQW	Approved	Small molecular drug	[23]
Phenoxybenzamine	DM8KSQH	Approved	Small molecular drug	[24]
Quinapril	DMR8H31	Approved	Small molecular drug	[25]
Reserpine	DM6VM38	Approved	Small molecular drug	[26]
Telmisartan	DMS3GX2	Approved	Small molecular drug	[27]
Trandolapril	DM4L6EU	Approved	Small molecular drug	[28]
Verapamil	DMA7PEW	Approved	Small molecular drug	[29]

Molecular Interaction Atlas (MIA) of This Disease

References

• [1] Acebutolol FDA Label
• [2] Amlodipine FDA Label
• [3] Atenolol FDA Label
• [4] Betaxolol FDA Label
• [5] Bisoprolol FDA Label
• [6] Candesartan FDA Label
• [7] Captopril FDA Label
• [8] Diazoxide FDA Label
• [9] Diltiazem FDA Label
• [10] Dipyridamole FDA Label
• [11] Doxazosin FDA Label
• [12] Enalapril FDA Label
• [13] Enalaprilat FDA Label
• [14] Fosinopril FDA Label
• [15] Hydralazine FDA Label
• [16] Hydrochlorothiazide FDA Label
• [17] Indapamide FDA Label
• [18] Labetalol FDA Label
• [19] A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
• [20] Metoprolol FDA Label
• [21] Minoxidil FDA Label
• [22] Nitroprusside FDA Label
• [23] Oxprenolol FDA Label
• [24] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [25] Quinapril FDA Label
• [26] Reserpine FDA Label
• [27] Telmisartan FDA Label
• [28] Trandolapril FDA Label
• [29] Verapamil FDA Label