Details of Disease | DrugMAP

General Information of Disease (ID: DISNWZJK)

Disease Name	Frontotemporal dementia and/or amyotrophic lateral sclerosis 6
Synonyms	amyotrophic lateral sclerosis caused by mutation in VCP; VCP amyotrophic lateral sclerosis; amyotrophic lateral sclerosis, with or without frontotemporal dementia
Definition	Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the VCP gene.
Disease Hierarchy	DISPZM6A: Frontotemporal dementia with motor neuron disease DISWZ9CJ: Familial amyotrophic lateral sclerosis DIS2B7L2: Frontotemporal dementia and/or amyotrophic lateral sclerosis DISNWZJK: Frontotemporal dementia and/or amyotrophic lateral sclerosis 6
Disease Identifiers	MONDO ID MONDO_0013501 UMLS CUI C5436279 OMIM ID 613954 MedGen ID 1759760

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
VCP	OTWIX1JU	Strong	Autosomal dominant	[1]
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This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
VCP	TTYWTI0	Strong	Autosomal dominant	[1]
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References

1	The Gene Curation Coalition: A global effort to harmonize gene-disease evidence resources. Genet Med. 2022 Aug;24(8):1732-1742. doi: 10.1016/j.gim.2022.04.017. Epub 2022 May 4.